5-BROMO-4-FLUORO-2-METHYLANILINE

Product Name: 5-BROMO-4-FLUORO-2-METHYLANILINE
CAS No.: 627871-16-3
Chemical Name: 5-BROMO-4-FLUORO-2-METHYLANILINE
Synonyms: 5-Bromo-4-fL;2-Methyl-4-fluoro-5-bromoaniline;BenzenaMine,5-broMo-4-fluoro-2-Methyl-;5-BROMO-4-FLUORO-2-METHYLANILINE ISO 9001：2015 REACH;2-Amino-4-bromo-5-fluorotoluene, 5-Bromo-4-fluoro-o-toluidine;5-Bromo-4-fluoro-2-methylaniline【2-Amino-4-bromo-5-fluorotoluene】;2-AMino-4-broMo-5-fluorotoluene[5-BroMo-4-fluoro-2-Methylaniline]
CBNumber: CB8972996
Molecular Formula: C7H7BrFN
Formula Weight: 204.04
MOL File: 627871-16-3.mol

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5-BROMO-4-FLUORO-2-METHYLANILINE Property

Melting point:: 86-90 °C (lit.)
Boiling point:: 266.3±35.0 °C(Predicted)
Density: 1.589±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 3.44±0.10(Predicted)
form: Solid
Appearance: Off-white to light brown Solid
InChI: InChI=1S/C7H7BrFN/c1-4-2-6(9)5(8)3-7(4)10/h2-3H,10H2,1H3
InChIKey: DNCLVDGUXUSPTL-UHFFFAOYSA-N
SMILES: C1(N)=CC(Br)=C(F)C=C1C

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 2921420090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 639036
Product name: 5-Bromo-4-fluoro-2-methylaniline
Purity: 97%
Packaging: 5g
Price: $97.85
Updated: 2025/07/31

TRC

Product number: B683645
Product name: 5-Bromo-4-fluoro-2-methylaniline
Packaging: 1g
Price: $60
Updated: 2021/12/16

TRC

Product number: B683645
Product name: 5-Bromo-4-fluoro-2-methylaniline
Packaging: 5g
Price: $140
Updated: 2021/12/16

AK Scientific

Product number: J91678
Product name: 5-Bromo-4-fluoro-2-methylaniline
Packaging: 1g
Price: $10
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3730-B-54
Product name: 5-Bromo-4-fluoro-2-methylaniline
Purity: 97%
Packaging: 1g
Price: $40
Updated: 2021/12/16

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5-BROMO-4-FLUORO-2-METHYLANILINE Chemical Properties,Usage,Production

Chemical Properties

light brown solid

Uses

5-Bromo-4-fluoro-2-methylaniline is used to prepare 3,4-dihydro-1H-[1]-benzothieno[2,3-c]pyran and 3,4-dihydro-1H-pyrano[3,4-b]benzofuran derivatives as non-nucleoside inhibitors of HCV NS5B RNA dependent RNA polymerase.

Synthesis

224185-19-7

627871-16-3

The general procedure for the synthesis of 5-bromo-4-fluoro-2-methylaniline from 2-nitro-4-bromo-5-fluorotoluene was as follows: a mixture of iron powder (17.8 g, 318 mmol) and ammonium chloride (5.10 g, 95.4 mmol) in water (100 mL) was heated to reflux for 30 minutes. Subsequently, 4-bromo-3-fluoro-6-nitrotoluene (18.6 g, 79.5 mmol) was slowly added to this hot mixture and the reaction mixture was continued to reflux for 48 hours. Upon completion of the reaction, the mixture was cooled to room temperature and extracted with ethyl acetate (3 x 200 mL). The organic phases were combined, washed sequentially with water (3 × 300 mL) and brine (300 mL), dried over anhydrous sodium sulfate and concentrated. The residue was purified by fast column chromatography (silica gel as stationary phase and hexane solution of 20% ethyl acetate as eluent) to afford 11.7 g of 5-bromo-4-fluoro-2-methylaniline as a light yellow solid in 72% yield. The product was characterized by 1H NMR (CDCl3, 300 MHz): δ 6.82 (m, 2H), 3.49 (bs, 2H), 2.11 (s, 3H).

References

[1] Advanced Synthesis and Catalysis, 2012, vol. 354, # 2-3, p. 321 - 327
[2] Patent: WO2003/99824, 2003, A1. Location in patent: Page 32
[3] Patent: WO2003/99275, 2003, A1. Location in patent: Page 65
[4] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 2, p. 457 - 460
[5] Journal of Medicinal Chemistry, 2004, vol. 47, # 26, p. 6603 - 6608

5-BROMO-4-FLUORO-2-METHYLANILINE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-BROMO-4-FLUORO-2-METHYLANILINE Suppliers

China 147 India 4 Switzerland 1 United Kingdom 2 United States 13 Global 167

Suzhou Daolan Biomedical Technology Co., Ltd.

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Beijing Eternalchem Co,. Ltd.

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China DongFan Chemical Co.,LTD

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skychemical Co.Ltd

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View Lastest Price from 5-BROMO-4-FLUORO-2-METHYLANILINE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 5-BROMO-4-FLUORO-2-METHYLANILINE 627871-16-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 5-BROMO-4-FLUORO-2-METHYLANILINE 627871-16-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

Career Henan Chemical Co

Product: 5-BROMO-4-FLUORO-2-METHYLANILINE 627871-16-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-12-25

627871-16-3, 5-BROMO-4-FLUORO-2-METHYLANILINERelated Search:

Ethanone,1-(2-amino-4-bromo-5-fluorophenyl)- 4-Bromo-5-fluoro-2-nitrotoluene 4-BROMO-5-FLUORO-7-METHYL ISATIN AKOS 91776 5-BROMO-4-FLUORO-2-METHYLANILINE 2-AMINO-4-BROMO-5-FLUOROBENZOIC ACID 4-BROMO-5-FLUORO-2-NITROBENZOIC ACID

BenzenaMine,5-broMo-4-fluoro-2-Methyl-

2-AMino-4-broMo-5-fluorotoluene[5-BroMo-4-fluoro-2-Methylaniline]

2-Amino-4-bromo-5-fluorotoluene, 5-Bromo-4-fluoro-o-toluidine

2-Methyl-4-fluoro-5-bromoaniline

5-Bromo-4-fL

5-BROMO-4-FLUORO-2-METHYLANILINE ISO 9001：2015 REACH

5-Bromo-4-fluoro-2-methylaniline【2-Amino-4-bromo-5-fluorotoluene】

627871-16-3

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