NS8593 HYDROCHLORIDE
- Product Name
- NS8593 HYDROCHLORIDE
- CAS No.
- 875755-24-1
- Chemical Name
- NS8593 HYDROCHLORIDE
- Synonyms
- NS8593;NS8593 HCl;NS8593 HYDROCHLORIDE;N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]-1H-benzimidazol-2-amine;: N-[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]-1H-Benzimidazol-2-amine hydrochloride;NS8593 hydrochloride,inhibit,NS8593,neurological,Ca2+,Inhibitor,hIK,SK1,SK2,KcsA,Potassium Channel,NS-8593,SK3,hBK,neurons,NS-8593 hydrochloride,dopaminergic,NS 8593,channel
- CBNumber
- CB8973069
- Molecular Formula
- C17H17N3.ClH
- Formula Weight
- 299.803
- MOL File
- 875755-24-1.mol
NS8593 HYDROCHLORIDE Property
- storage temp.
- 2-8°C
- solubility
- DMSO: >10mg/mL
- form
- powder
- color
- White to off-white
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- 492031
- Product name
- NS8593
- Purity
- An aminobenzimidazole derivative that selectively and reversibly blocks small conductance Ca2+-activated K+ channels in a Ca2+-dependent manner.
- Packaging
- 10MG
- Price
- $196
- Updated
- 2024/03/01
- Product number
- N2538
- Product name
- NS8593 hydrochloride
- Purity
- ≥98% (HPLC), powder
- Packaging
- 5mg
- Price
- $169
- Updated
- 2022/05/15
- Product number
- N2538
- Product name
- NS8593 hydrochloride
- Purity
- ≥98% (HPLC), powder
- Packaging
- 25mg
- Price
- $638
- Updated
- 2022/05/15
- Product number
- 29774
- Product name
- NS 8593 (hydrochloride)
- Packaging
- 1mg
- Price
- $29
- Updated
- 2024/03/01
- Product number
- 29774
- Product name
- NS 8593 (hydrochloride)
- Packaging
- 25mg
- Price
- $393
- Updated
- 2024/03/01
NS8593 HYDROCHLORIDE Chemical Properties,Usage,Production
Description
NS 8593 is an inhibitory gating modifier of small-conductance calcium-activated potassium (KCa2/SK) channels (Kds = 0.42, 0.6, and 0.73 μM for KCa2.1/SK1, KCa2.2/SK2, and KCa2.3/SK3, respectively, in the presence of calcium) that decreases the calcium sensitivity of SK channels. It is selective for KCa2/SK channels over intermediate- (KCa3.1/IKCa1) and large-conductance (BK) potassium channels at 10 μM. NS 8593 induces relaxation of potassium- or acetylcholine chloride-precontracted isolated tracheal rings from wild-type mice (IC50s = 8.9 and 39.8 μM, respectively) or from mice in an ovalbumin-induced model of allergic asthma (IC50s = 16.4 and 32.2 μM, respectively). It inhibits aerosolized acetylcholine chloride-induced increases in respiratory system resistance in mice when administered as an aerosol at a dose of 500 μM. NS 8593 (5 mg/kg) decreases the duration of burst-pacing-induced atrial fibrillation in normotensive and spontaneously hypertensive rats.
Uses
NS8593 hydrochloride has been used to study its effect on the growth of MDA-MB-231 cells (M.D. Anderson and metastasis breast cancer cells).
Biochem/physiol Actions
The compound (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphtylamine (NS8593) reversibly inhibited recombinant SK3-mediated currents (human and rat SK3) with potencies around 100 nM. NS8593 did not inhibit 125I-apamin binding. NS8593 decreased the calcium sensitivity by shifting the activation curve for Ca2+ to the right, only slightly affecting the maximal Ca2+-activated SK current. NS8593 inhibited all the SK1-3 subtypes Ca2+-dependently (Kd = 0.42, 0.60, and 0.73 μM, respectively, at 0.5 μM Ca2+. NS8593 did not affect the calcium-activated potassium channels of intermediate and large conductance (hIK and hBK channels, respectively). NS8593-mediated inhibition was prevented in the presence of a high concentration of the positive modulator NS309.
storage
Store at +4°C
NS8593 HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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