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GSK3685032

Product Name
GSK3685032
Chemical Name
GSK3685032
Synonyms
GSK3685032
CBNumber
CB89735154
Formula Weight
0
MOL File
Mol file
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Hazard and Precautionary Statements (GHS)

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GSK3685032 Chemical Properties,Usage,Production

Definition

GSK-3685032 is a non-time-dependent, noncovalently, first-in-class reversible DNMT1-selective inhibitor, with an IC50 of 0.036 μM. GSK-3685032 induces robust loss of DNA methylation, transcriptional activation, and cancer cell growth inhibition.

Mechanism of action

GSK3685032 is a potent first-in-class DNMT1-selective inhibitor shown via crystallographic studies to compete with the active-site loop of DNMT1 for penetration into hemimethylated DNA between two CpG base pairs. GSK3685032 induces robust loss of DNA methylation, transcriptional activation, and cancer cell growth inhibition in vitro[1].

References

[1] M. Pappalardi. “Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia.” Nature cancer 2 1 (2021): 1002–1017.

GSK3685032 Preparation Products And Raw materials

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GSK3685032 Suppliers

Chengdu Junepharma Technology Co., Ltd
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19938173342 19181793067
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1486288711@qq.com
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China
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Nantong Hi-Future Biotechnology Co., Ltd
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18051384581
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sales@chemhifuture.com
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China
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Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
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024-024-88590548 18341751992
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China
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891
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Wuhan Jingkangen Biomedical Technology Co., Ltd
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13720134139 13720134139
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orders@jknbiochem.com
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China
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Wuhan Jingkang en Biomedical Technology Co., Ltd
Tel
+8613720134139
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orders@jknbiochem.com
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China
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5221
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Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
Tel
+86-18341751992 +86-15382112998
Email
757984502@qq.com
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China
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892
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Nantong HI-FUTURE Biology Co., Ltd.
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+undefined18051384581
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