Baxdrostat
- Product Name
- Baxdrostat
- CAS No.
- 1428652-17-8
- Chemical Name
- Baxdrostat
- Synonyms
- RG-7641;CIN-107;RO-6836191;Baxdrostat;Baxdrostat, 10 mM in DMSO;(R)-N-(4-(1-Methyl-2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)-5,6,7,8-tetrahydroisoquinolin-8-yl)propionamide;Propanamide, N-[(8R)-5,6,7,8-tetrahydro-4-(1,2,3,4-tetrahydro-1-methyl-2-oxo-6-quinolinyl)-8-isoquinolinyl]-;(+)-(R)-N-(4-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)-5,6,7,8-tetrahydroisoquinolin-8-yl)propionamide
- CBNumber
- CB89763124
- Molecular Formula
- C22H25N3O2
- Formula Weight
- 363.45
- MOL File
- 1428652-17-8.mol
Baxdrostat Property
- Boiling point:
- 697.6±55.0 °C(Predicted)
- Density
- 1.24±0.1 g/cm3(Predicted)
- solubility
- DMSO : 250 mg/mL (687.85 mM; Need ultrasonic)
- pka
- 15.05±0.20(Predicted)
- form
- Solid
- color
- Off-white to light yellow
- InChI
- InChI=1S/C22H25N3O2/c1-3-21(26)24-19-6-4-5-16-17(12-23-13-18(16)19)14-7-9-20-15(11-14)8-10-22(27)25(20)2/h7,9,11-13,19H,3-6,8,10H2,1-2H3,(H,24,26)/t19-/m1/s1
- InChIKey
- VDEUDSRUMNAXJG-LJQANCHMSA-N
- SMILES
- C(N[C@H]1C2=C(CCC1)C(C1C=CC3=C(C=1)CCC(=O)N3C)=CN=C2)(=O)CC
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
Baxdrostat Chemical Properties,Usage,Production
Uses
Baxdrostat is a novel aldosterone synthase Inhibitor for treatment resistant hypertension and systemic Hypertension.
Mode of action
The mechanism of action of baxdrostat as an aldosterone synthase inhibitor demonstrates the inextricable linkage between sodium and blood pressure regulation. Baxdrostat significantly decreases aldosterone in plasma and urine, while increasing plasma renin as a physiological compensatory change.
Baxdrostat Preparation Products And Raw materials
Raw materials
Preparation Products
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