6-Methyleneandrost-4-ene-3,17-dione
- Product Name
- 6-Methyleneandrost-4-ene-3,17-dione
- CAS No.
- 19457-55-7
- Chemical Name
- 6-Methyleneandrost-4-ene-3,17-dione
- Synonyms
- Exemestane impurity E;1,2-Dihydro ExeMestane;Exemestane EP Impurity E;Intermediate of Exemestane;ExeMestane Related CoMpound A;Exemestane intermediate object;6- times methyl-4-androstenedione;Exemestane USP Related Compound A;Exemestane Tablets USP Impurity i;6- methyl -4- two ketone (steroid)
- CBNumber
- CB91010920
- Molecular Formula
- C20H26O2
- Formula Weight
- 298.42
- MOL File
- 19457-55-7.mol
6-Methyleneandrost-4-ene-3,17-dione Property
- Melting point:
- 163-165 °C
- Boiling point:
- 450.8±45.0 °C(Predicted)
- Density
- 1.11±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Chloroform (Sparingly), DMSO (Heated), Methanol (Slightly)
- form
- Solid
- color
- Pale Yellow to Light Beige
- InChI
- InChI=1S/C20H26O2/c1-12-10-14-15-4-5-18(22)20(15,3)9-7-16(14)19(2)8-6-13(21)11-17(12)19/h11,14-16H,1,4-10H2,2-3H3/t14-,15-,16-,19+,20-/m0/s1
- InChIKey
- KQRGETZTRARSMA-DAELLWKTSA-N
- SMILES
- C1(=O)C=C2[C@](C)(CC1)[C@]1([H])[C@]([H])([C@@]3([H])[C@@](CC1)(C)C(=O)CC3)CC2=C
Safety
- HS Code
- 2914299000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H361Suspected of damaging fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P281Use personal protective equipment as required.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- PHR1894
- Product name
- Exemestane Related Compound A
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 30MG
- Price
- $492.1
- Updated
- 2025/07/31
- Product number
- 1269061
- Product name
- Exemestane Related Compound A
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 15MG
- Price
- $1120
- Updated
- 2025/07/31
- Product number
- M3121
- Product name
- 6-Methyleneandrost-4-ene-3,17-dione
- Purity
- >98.0%(HPLC)
- Packaging
- 1g
- Price
- $56
- Updated
- 2025/07/31
- Product number
- M3121
- Product name
- 6-Methyleneandrost-4-ene-3,17-dione
- Purity
- >98.0%(HPLC)
- Packaging
- 5g
- Price
- $188
- Updated
- 2025/07/31
- Product number
- D449515
- Product name
- 1,2-DihydroExemestane
- Packaging
- 100mg
- Price
- $140
- Updated
- 2021/12/16
6-Methyleneandrost-4-ene-3,17-dione Chemical Properties,Usage,Production
Uses
1,2-Dihydro Exemestane is a related compound of Exemestane (E957000).
Synthesis
50-00-0
63-05-8
19457-55-7
The general procedure for the synthesis of (8R,9S,10R,13S,14S)-10,13-dimethyl-6-methylene-7,8,9,10,11,12,13,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17(2H,6H)-dione from formaldehyde and androstenedione was as follows: 2.0 g of androst-4-ene-3,17 -dione (0.01 mol) was dissolved in 13 mL of anhydrous THF and 2 mL of ethanol, 2 mL of anhydrous triethyl orthoformate and 26 mg of p-toluenesulfonic acid monohydrate were added. The reaction mixture was stirred at 40 °C for about 1 hour. Subsequently, 50 mg of p-toluenesulfonic acid monohydrate was added and stirring was continued for about 2 hours. After the reaction was completed, cooled to room temperature, 1 mL of N-methylaniline and 1 mL of 40% formaldehyde aqueous solution was added to the reaction flask and the mixture was stirred at 40°C for about 4 hours. After cooling to room temperature again, 10 mL of 37% HCl was added and stirring was continued for 2 hours. The reaction solution was transferred to a partition funnel and extracted with EtOAc. The organic phase was dried with Na2SO4 and purified by silica gel chromatography to afford 0.84 g of 6-methylene-androst-4-ene-3,17-dione (3) as a white solid with >95% chemical purity and a melting point of 159-163 °C.
References
[1] Patent: WO2010/76811, 2010, A2. Location in patent: Page/Page column 9
[2] Steroids, 2013, vol. 78, # 11, p. 1148 - 1151
[3] Patent: CN105622694, 2016, A. Location in patent: Paragraph 0010
6-Methyleneandrost-4-ene-3,17-dione Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Methyleneandrost-4-ene-3,17-dione manufacturers
- Product
- 6-Methyleneandrost-4-ene-3,17-dione 19457-55-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-01-18
- Product
- 6-methyleneandrost-4-ene-3,17-dione 19457-55-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000kg
- Release date
- 2025-02-26
- Product
- 6-Methylene-4-Androsten-3,17-dione 19457-55-7
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 1000kg
- Release date
- 2025-04-18