ChemicalBook > CAS DataBase List > ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA)

ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA)

Product Name: ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA)
CAS No.: 850649-61-5
Chemical Name: ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA)
Synonyms: Alogliptin;Trajenta;Alogliptin (SYR-322);ALOGLIPTINA;Axagliptin hydrate;ogL;Agelieting;ALOGLIPTINE;Alogliptin,98%;Unii-jhc049lo86
CBNumber: CB91011068
Molecular Formula: C18H21N5O2
Formula Weight: 339.39
MOL File: 850649-61-5.mol

Less

ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) Property

Melting point:: 127 - 129°C
Boiling point:: 519.2±60.0 °C(Predicted)
Density: 1.342
Flash point:: 267.8℃
storage temp.: Refrigerator
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
pka: 9.89±0.20(Predicted)
form: Solid
color: White to Off-White
InChI: InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1
InChIKey: ZSBOMTDTBDDKMP-OAHLLOKOSA-N
SMILES: C(#N)C1=CC=CC=C1CN1C(=O)N(C)C(=O)C=C1N1CCC[C@@H](N)C1

Less

Safety

Safety Statements: 24/25
RIDADR: 3077
HS Code: 29335990
Hazardous Substances Data: 850649-61-5(Hazardous Substances Data)

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

TRC

Product number: A575425
Product name: Alogliptin
Packaging: 100mg
Price: $325
Updated: 2021/12/16

Ark Pharm

Product number: P000456262
Product name: Alogliptin
Purity: 98+%
Packaging: 100mg
Price: $28
Updated: 2021/12/16

ApexBio Technology

Product number: A4038
Product name: Alogliptin(SYR-322)
Packaging: 1unit
Price: $28
Updated: 2021/12/16

AK Scientific

Product number: J99093
Product name: Alogliptin
Packaging: 1mg
Price: $34
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA17319
Product name: Alogliptin
Packaging: 10mg
Price: $40
Updated: 2021/12/16

Less

ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) Chemical Properties,Usage,Production

Description

Alogliptin is a dipeptidyl-peptidase IV (DPP-4) inhibitor that was approved in Japan in 2010 for treatment of type 2 diabetes, a disease in which insulin resistance and β-cell dysfunction lead to hyperglycemia. As islet function is lost, the severity of insulin resistance increases. The introduction of DPP-4 inhibitors has brought a novel class of insulinotropic agents for the treatment options available to type 2 diabetic patients. The therapeutic potential of glucagon-like peptide 1 (GLP-1), an incretin peptide, for the treatment of type 2 diabetes was realized in the 1990s. The insulinotropic effects of GLP-1 depend closely on glucose concentrations providing the possibility of glucose normalization without the risk of hypoglycemia. GLP-1 has other non-insulinotropic physiological actions that are advantageous. It suppresses glucagon secretion from a cells and slows gastric emptying, which contributes to satiety and to a slower passage and reabsorption of carbohydrates. GLP-1 also contributes to satiety via a central mechanism as a neurotransmitter with effects on the hypothalamus.

Chemical Properties

White Solid

Originator

Syrrx Inc. (now Takeda San Diego) (Japan)

Uses

Alogliptin is an oral antihyperglycemic agent that is a selective inhibitor of the enzyme dipeptidyl peptidase-4 (DPP-4). Antidiabetic agent.

Definition

ChEBI: A piperidine that is 3-methyl-2,4-dioxo-3,4-dihydropyrimidine carrying additional 2-cyanobenzyl and 3-aminopiperidin-1-yl groups at positions 1 and 2 respectively (the R-enantiomer). Used in the form of its benzoate salt for treatment of t pe 2 diabetes.

brand name

Nesina

Clinical Use

Dipeptidyl peptidase 4 inhibitor:
Treatment of type 2 diabetes in combination with other therapies

Synthesis

1246610-74-1

850649-61-5

To the reaction flask was added 160.0 g (0.36 mol) of alogliptin precursor (III) and 2 L of methanol and stirred until complete dissolution. Subsequently, 46.0 g of trifluoroacetic acid was added and the reaction mixture was stirred at 65 °C for 7 h. The reaction was monitored by TLC until completion. After completion of the reaction, the reaction solution was slowly added dropwise to 2 L of water under stirring and stirring was continued for 30 minutes. The precipitate was collected by filtration and the filter cake was mixed with saturated sodium bicarbonate solution and stirred for 30 minutes to neutralize. The filter was again filtered and the filter cake was washed with water. Finally, recrystallization was carried out using a mixed isopropanol-ethanol solvent to give a white solid product. The product was dried under vacuum at 60 °C for 12 h to give 102.5 g of (R)-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile in 83% yield, 98.9% purity, and a melting point of 126~128 °C.

target

DPP-4

Metabolism

Alogliptin does not undergo extensive metabolism. Two minor metabolites were detected following administration of an oral dose of [14C]-alogliptin, N-demethylated alogliptin, M-I (<1% of the parent compound), and N-acetylated alogliptin, M-II (<6% of the parent compound). M-I is an active metabolite and is a highly selective inhibitor of DPP-4 similar to alogliptin; M-II does not display any inhibitory activity towards DPP-4 or other DPP-related enzymes. In vitro data indicate that CYP2D6 and CYP3A4 contribute to the limited metabolism of alogliptin.

References

[1] Patent: CN104086527, 2016, B. Location in patent: Paragraph 0052; 0061-0063; 0074
[2] Patent: CN105777709, 2016, A. Location in patent: Paragraph 0069; 0070
[3] Patent: CN106336396, 2017, A. Location in patent: Paragraph 0013-0119
[4] Patent: WO2015/92807, 2015, A1. Location in patent: Sheet 8
[5] Patent: CN103910710, 2017, B. Location in patent: Paragraph 0064-0065

ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) Preparation Products And Raw materials

Raw materials

Preparation Products

Less

ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) Suppliers

Canada 1 China 246 India 19 United Kingdom 3 United States 15 Global 284

Hubei Chenxin Pharmaceutical Co., Ltd.

Tel: 17362916295 17362916295;
Fax: QQ:840947394
Email: w17362916295@163.com
Country: China
ProdList: 3004
Advantage: 58

Hangzhou Yinghui Industrial Co.,Ltd

Tel: 15355417531
Email: 2028755477@qq.com
Country: China
ProdList: 152
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chemvon Biotechnology Co., Ltd

Tel: 021-50790412
Fax: +86-21-50790419
Email: info@chemvon.com
Country: China
ProdList: 371
Advantage: 57

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Jinan Trio PharmaTech Co., Ltd.

Tel: 0531-88811783
Fax: +86 (531) 55696010 QQ 1762738062
Email: sales@trio-pharmatech.com
Country: China
ProdList: 1856
Advantage: 62

Hangzhou Yuhao Chemical Technology Co., Ltd

Tel: 0571-82693216
Fax: +86-571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 6387
Advantage: 52

Shanghai Sphchem Co., Ltd.

Tel: 021-56491756 13512199871
Fax: 021-5649-1756
Email: 2819742715@qq.com
Country: China
ProdList: 4000
Advantage: 55

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4747
Advantage: 58

BioBioPha Co., Ltd.

Tel: 0871-65217109 13211707573;
Fax: 0871-65215563
Email: y.liu@mail.biobiopha.com
Country: China
ProdList: 5653
Advantage: 65

S.Z. PhyStandard Bio-Tech. Co., Ltd.

Tel: 0755-83725681-603
Fax: +86 755 28094224
Country: China
ProdList: 4496
Advantage: 50

Hefei Topway Biotechnology Co.,Ltd

Tel: 0551-65326752 14755135869
Fax: 0086-551-65326751
Email: xxhasym@163.com
Country: China
ProdList: 49
Advantage: 60

The future of Shanghai Industrial Co., Ltd.

Tel: 021-61552785
Fax: 021-55660885
Email: sales@shshiji.com
Country: China
ProdList: 9546
Advantage: 55

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4720
Advantage: 55

Nanjing Sunlida Biological Technology Co., Ltd.

Tel: 025-57798810
Fax: 025-57019371
Email: sales@sunlidabio.com
Country: China
ProdList: 3239
Advantage: 55

Cangzhou Senary Chemical Science-tech Co., Ltd

Tel: +86-317-3563899
Fax: +86-317-3563199
Email: trade@senary.com
Country: China
ProdList: 98
Advantage: 56

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7783
Advantage: 58

Jinan Mingya Medical Technology Co., Ltd.

Tel: 0531-85828981
Fax: +86-531-85806006
Email: 864598798@qq.com
Country: China
ProdList: 588
Advantage: 58

Hubei XinyuanShun Chemical Co., Ltd.

Tel: 13971561712, 13995564702, 027-50664929
Fax: 027-50664927
Email: hbeixys2001@163.com
Country: China
ProdList: 3120
Advantage: 55

Eastbang Pharmaceuticals Technology Co., Ltd.

Tel: +86 (20) 28996708,29078958,28139708,29076128,28133708,28139728,28139738,28133718,021-31663278,021-31663578,021-60538387
Fax: +86 (20) 39218032
Country: China
ProdList: 454
Advantage: 58

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18333
Advantage: 56

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
Advantage: 58

Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9637
Advantage: 58

Shanghai Balmxy Pharmaceutical Co., Ltd

Tel: 021-24206007 13764915196
Fax: 86-021-23027023
Email: sales@balmxy.com
Country: China
ProdList: 6874
Advantage: 55

NINGBO INNO PHARMCHEM CO.,LTD.

Tel: 86-574-27787657
Fax: 86-574-27912196
Email: info@dearchem.com
Country: China
ProdList: 4613
Advantage: 58

Wuhan Dahua Pharmaceutical Co., Ltd.

Tel: 027-59262863 13277907145 3091977954
Fax: 027-59420980
Country: China
ProdList: 4942
Advantage: 58

Shanghai YuLue Chemical Co., Ltd.

Tel: 021-60345187 13671753212
Fax: 021-34702061
Email: lzz841106@aliyun.com
Country: China
ProdList: 10263
Advantage: 55

Shanghai Kewel Chemical Co., Ltd.

Tel: 021-64609169 18901607656
Fax: 021-64609160
Email: greensnown@163.com
Country: China
ProdList: 9906
Advantage: 50

Lihe Wuhan New Chemical Materials Co., Ltd.

Tel: 027-88395709
Fax: 027-88391805
Country: China
ProdList: 429
Advantage: 50

Credit Asia Chemical Co., Ltd.

Tel: +86 (21) 61124340
Fax: +86 (21) 6129-4103
Country: China
ProdList: 9756
Advantage: 58

Hubei Jusheng Technology Co.,Ltd

Tel: 027-59599241 18871490274
Fax: 027-59599241
Email: 1400878000@qq.com
Country: China
ProdList: 9858
Advantage: 58

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

Chizhou Kailong Import and Export Trade Co., Ltd.

Tel
Fax: -
Email: xg01_gj@163.com
Country: China
ProdList: 9484
Advantage: 50

Watson Biotechnology Co.,Ltd

Tel: 027-59207879 1972026995 18140587686
Fax: QQ：1972026995
Email: sales@3600chem.com
Country: China
ProdList: 4447
Advantage: 55

Nanjing Chempioneer Pharmaceutical Co., Ltd.

Tel: 18068075658
Fax: -
Email: sales@chempioneer.com
Country: China
ProdList: 1811
Advantage: 58

Shanghai Synchem Pharma Co., ltd

Tel: 21-619849051-1 18521059765
Email: synchempharma@aliyun.com
Country: China
ProdList: 6468
Advantage: 55

Chengdu RunZeBenTu Chemical Co., Ltd

Tel: 028-88469284 18000562381
Email: rzbtsj@163.com
Country: China
ProdList: 9951
Advantage: 56

Codow Chemical Co.,Ltd.

Tel: 18620099427
Fax: +86-20-62619665
Email: amy@howeipharm.com
Country: China
ProdList: 6687
Advantage: 55

Jinan Putubio Tech Co., Ltd.

Tel: +86 (531) 8099-2215
Fax: +86 (531) 8099-2215
Email: putubio@outlook.com
Country: China
ProdList: 1261
Advantage: 55

ShangHai Siyan Biological Technology Co., Ltd.

Tel: 021-50908862，442785678，326799392 18721037013
Fax: 021-50908862
Email: siyansales@126.com
Country: China
ProdList: 9627
Advantage: 58

Artis Biotech Co. Ltd.

Tel: 028-67271278 18628360895
Fax: 0575-89298961
Email: sales@artisbio.com
Country: China
ProdList: 1960
Advantage: 58

Beijing Cooperate Pharmaceutical Co.,Ltd

Tel: +86-010-60279497 +86-15646567669
Fax: 010-60279497
Email: sales01@cooperate-pharm.com
Country: China
ProdList: 137
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Shanghai QianYan Bio-technology Co., Ltd

Tel: 02781293128
Email: orders@biochemsafebuy.com
Country: China
ProdList: 9923
Advantage: 55

Cangzhou Enke Pharma-tech Co., Ltd.

Tel: 0317-5296180 15533709196
Fax: 0317-5106596
Email: sale@enkepharma.com
Country: China
ProdList: 2267
Advantage: 55

Raw material medicin reagent co.,Ltd

Tel
Email: sales@njromanme.com
Country: China
ProdList: 4529
Advantage: 58

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

ChengDu TongChuangYuan Pharmaceutical Co.Ltd

Tel: 028-83379370 13880556291
Fax: 028-87747383
Email: tcy@tcypharm.com
Country: China
ProdList: 7218
Advantage: 58

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9125
Advantage: 58

Zhengzhou Acme Chemical Co., Ltd.

Tel: 0371-0371-55629727 13323845623
Fax: 037155629727
Email: 2885676761@qq.com
Country: China
ProdList: 10110
Advantage: 58

Less

View Lastest Price from ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) 850649-61-5
Price: US $10.00/KG
Min. Order: 100KG
Purity: 99%
Supply Ability: 100 mt
Release date: 2024-12-02

HangZhou RunYan Pharma Technology Co.,LTD.

Product: ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) 850649-61-5
Price: US $0.00-0.00/g
Min. Order: 10000g
Purity: 99% HPLC
Supply Ability: 1000kg
Release date: 2024-11-20

Nanjing Fred Technology Co., Ltd

Product: Alogliptin 850649-61-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%，single impurity＜0.1
Supply Ability: 1 ton
Release date: 2024-01-04

850649-61-5, ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA)Related Search:

Alogliptin Related Compound 26 Benzonitrile, 2-[(tetrahydro-3-Methyl-2,4,6-trioxo-1(2H)-pyriMidinyl)Methyl]- 2,4(1H,3H)-Pyrimidinedione, 6-methoxy-3-methyl- (S)-Alogliptin Benzoate Salt Alogliptin iMpurity AGOMELATINE Linagliptin Alogliptin benzoate Trelagliptin Vonoprazan fumarate Trelagliptin succinate Teneligliptin Hydrobromide Tozasertib Telmisartan Atazanavir sulfate Erteberel (LY500307) Rapamycin Olaparib

Alogliptin (SYR-322)

Alogliptin(free base)

Benzonitrile, 2-[[6-[(3R)-3-aMino-1-piperidinyl]-3,4-dihydro-3-Methyl-2,4-dioxo-1(2H)-pyriMidinyl]Methyl]-

Axagliptin hydrate

(R)-2-[6-(3-aMino-piperidin-1-yl)-3-Methyl-2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl)Methyl]-benzonitrile

Alogliptin Benzoate API

Alogliptin 2-[[6-[(3R)-3-Amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]benzonitrile

Trajenta

ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA)

Alogliptin

Unii-jhc049lo86

2-[[6-[(3R)-3-Amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]benzonitrile

ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA)###850649-61-5

Trelagliptin-11

Alogliptin Intermediate

ALOGLIPTIN(ALOGLIPTINE

ALOGLIPTINA

Trelagliptin Impurity T

(R)-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitri

Alogliptin, 99%, effective and selective DPP-4 inhibitor

Trelagliptin Impurity 2(Alogliptin)

Alogliptin,98%

ogL

Troxagliptin impurities141

Troxagliptin impuritiesT

Alogliptin 13C6

AlogliptinQ: What is Alogliptin Q: What is the CAS Number of Alogliptin Q: What is the storage condition of Alogliptin Q: What are the applications of Alogliptin

ALOGLIPTINE

Alogliptin Base

Trelagllptin Impurity 2

Agelieting

Alogliptin, 10 mM in DMSO

Alogliptin（850649-61-5）

850649-61-5

Inhibitor

Intermediates & Fine Chemicals

Pharmaceuticals

intermediat

Inhibitors

Amines

Aromatics

Chiral Reagents

Heterocycles