ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA)
- Product Name
- ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA)
- CAS No.
- 850649-61-5
- Chemical Name
- ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA)
- Synonyms
- Alogliptin;Trajenta;Alogliptin (SYR-322);ALOGLIPTINA;Axagliptin hydrate;ogL;Agelieting;ALOGLIPTINE;Alogliptin,98%;Unii-jhc049lo86
- CBNumber
- CB91011068
- Molecular Formula
- C18H21N5O2
- Formula Weight
- 339.39
- MOL File
- 850649-61-5.mol
ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) Property
- Melting point:
- 127 - 129°C
- Boiling point:
- 519.2±60.0 °C(Predicted)
- Density
- 1.342
- Flash point:
- 267.8℃
- storage temp.
- Refrigerator
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 9.89±0.20(Predicted)
- color
- White to Off-White
Safety
- Safety Statements
- 24/25
- RIDADR
- 3077
- HS Code
- 29335990
- Hazardous Substances Data
- 850649-61-5(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A575425
- Product name
- Alogliptin
- Packaging
- 100mg
- Price
- $325
- Updated
- 2021/12/16
- Product number
- FA17319
- Product name
- Alogliptin
- Packaging
- 250mg
- Price
- $400
- Updated
- 2021/12/16
- Product number
- P000456262
- Product name
- Alogliptin
- Purity
- 98+%
- Packaging
- 5g
- Price
- $426
- Updated
- 2021/12/16
- Product number
- A4038
- Product name
- Alogliptin(SYR-322)
- Packaging
- 100mg
- Price
- $470
- Updated
- 2021/12/16
- Product number
- orb134884
- Product name
- Alogliptin
- Purity
- >99%
- Packaging
- 100mg
- Price
- $510
- Updated
- 2021/12/16
ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) Chemical Properties,Usage,Production
Description
Alogliptin is a dipeptidyl-peptidase IV (DPP-4) inhibitor that was approved in Japan in 2010 for treatment of type 2 diabetes, a disease in which insulin resistance and β-cell dysfunction lead to hyperglycemia. As islet function is lost, the severity of insulin resistance increases. The introduction of DPP-4 inhibitors has brought a novel class of insulinotropic agents for the treatment options available to type 2 diabetic patients. The therapeutic potential of glucagon-like peptide 1 (GLP-1), an incretin peptide, for the treatment of type 2 diabetes was realized in the 1990s. The insulinotropic effects of GLP-1 depend closely on glucose concentrations providing the possibility of glucose normalization without the risk of hypoglycemia. GLP-1 has other non-insulinotropic physiological actions that are advantageous. It suppresses glucagon secretion from a cells and slows gastric emptying, which contributes to satiety and to a slower passage and reabsorption of carbohydrates. GLP-1 also contributes to satiety via a central mechanism as a neurotransmitter with effects on the hypothalamus.
Chemical Properties
White Solid
Originator
Syrrx Inc. (now Takeda San Diego) (Japan)
Uses
Alogliptin is an oral antihyperglycemic agent that is a selective inhibitor of the enzyme dipeptidyl peptidase-4 (DPP-4). Antidiabetic agent.
Definition
ChEBI: A piperidine that is 3-methyl-2,4-dioxo-3,4-dihydropyrimidine carrying additional 2-cyanobenzyl and 3-aminopiperidin-1-yl groups at positions 1 and 2 respectively (the R-enantiomer). Used in the form of its benzoate salt for treatment of t pe 2 diabetes.
brand name
Nesina
Clinical Use
Dipeptidyl peptidase 4 inhibitor:
Treatment of type 2 diabetes in combination with
other therapies
target
DPP-4
Metabolism
Alogliptin does not undergo extensive metabolism. Two minor metabolites were detected following administration of an oral dose of [14C]-alogliptin, N-demethylated alogliptin, M-I (<1% of the parent compound), and N-acetylated alogliptin, M-II (<6% of the parent compound). M-I is an active metabolite and is a highly selective inhibitor of DPP-4 similar to alogliptin; M-II does not display any inhibitory activity towards DPP-4 or other DPP-related enzymes. In vitro data indicate that CYP2D6 and CYP3A4 contribute to the limited metabolism of alogliptin.
ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) manufacturers
- Product
- ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) 850649-61-5
- Price
- US $0.00-0.00/g
- Min. Order
- 10000g
- Purity
- 99% HPLC
- Supply Ability
- 1000kg
- Release date
- 2024-11-20
- Product
- ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) 850649-61-5
- Price
- US $10.00/KG
- Min. Order
- 100KG
- Purity
- 99%
- Supply Ability
- 100 mt
- Release date
- 2024-12-02
- Product
- Alogliptin 850649-61-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%，single impurity＜0.1
- Supply Ability
- 1 ton
- Release date
- 2024-01-04