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Atazanavir sulfate

Product Name
Atazanavir sulfate
CAS No.
229975-97-7
Chemical Name
Atazanavir sulfate
Synonyms
Zrivada;Cgp 75355;Aids060276;Aids-060276;BMS-232632-05;BMS232632 sulfate;BMS 232632 sulfate;BMS-232632 sulfate;Atazanavir Sulfate;Atazanavir Sulphate
CBNumber
CB3547456
Molecular Formula
C38H54N6O11S
Formula Weight
802.94
MOL File
229975-97-7.mol
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Atazanavir sulfate Property

Melting point:
195.0°, or acetone; mp 198-199° (dec)
alpha 
D22 -46.1° (c = 1 in 1:1 CH3OH/H2O, pH = 2.6)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
≥28.7 mg/mL in DMSO with gentle warming; insoluble in H2O; ≥4.05 mg/mL in EtOH with gentle warming and ultrasonic
form 
Powder
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Safety

Safety Statements 
24/25
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H318Causes serious eye damage

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P314Get medical advice/attention if you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
A790050
Product name
AtazanavirBisulfateSalt
Packaging
50mg
Price
$160
Updated
2021/12/16
Ark Pharm
Product number
P000492449
Product name
Atazanavir sulfate
Purity
98+%
Packaging
1g
Price
$30
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA29047
Product name
Atazanavir sulfate
Packaging
250mg
Price
$120
Updated
2021/12/16
ChemScene
Product number
CS-1890
Product name
Atazanavir(sulfate)
Purity
99.94%
Packaging
50mg
Price
$144
Updated
2021/12/16
Ark Pharm
Product number
P000492449
Product name
Atazanavir sulfate
Purity
98+%
Packaging
10g
Price
$149
Updated
2021/12/16
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Atazanavir sulfate Chemical Properties,Usage,Production

Description

Atazanavir (BMS-232632, III), an azapeptide HIV protease inhibitor, has been developed and launched by Bristol-Myers Squibb (BMS), under worldwide license from Novartis, for the treatment of HIV infection. Atazanavir was launched in the US as Reyataz™ in July 2003.

Chemical Properties

Off-White Solid

Uses

Atazanavir Sulfate is an intermediate of Atazanavir(A790051) which is a novel azapeptide HIV protease Inhbitor. Antiviral.

Uses

Atazanavir is a HIV protease inhibitor with Ki of 2.66 nM

Uses

Atazanavir is a novel azapeptide HIV protease inhibitor (PI). Antiviral.

brand name

Reyataz (Bristol-Myers Squibb).

Synthesis

The synthesis of atazanavir (III) appeared in several reports. The synthetic route depicted in the scheme was one of the best routes which was suitable for large scale production. The commercially available chiral diol 25 was converted to its silyl mesylate 26 in one pot via selective silylation and subsequent mesylation. This oily intermediate 26 was carried into the next step without further purification. The desilylation of 26 was achieved by using inexpensive ammonium fluoride. The resulting solid product 27 was readily isolated and further purified through recrystallization from IPA/H2O in 80% yield. The epoxide formation from 27 was affected by KOtBu in THF/IPA to provide enantiomerically pure epoxide 28 in 88% yield. Suzuki coupling of boronic acid 29 with bromopyridine (30) provided pyridyl benzaldehyde 31 in 80% yield after crystallization. The subsequent condensation of aldehyde 31 with t-butylcarbamate was carried out by refluxing in toluene/IPA and Shiff base 32 was collected by filtration upon cooling. Reduction of hydrazone 32 to hydrazine 33 was accomplished by employing a catalytic phase-transfer hydrogenation protocol (Pd/C, HCOONa) to furnish hydrazine 33 in 78% yield after crystallization. Coupling of the hydrazinocarbamate 33 with epoxide 28 was performed in refluxing IPA, followed by the addition of water to precipitate the crude product. Subsequent recrystallization from MeCN/H2O furnished 34 in 85% yield. Treatment of 34 with concentrated HCl in THF at 50oC removed the two Boc groups in 34 to give the product as an oil, which was then dissolved in a mixture of DCM/DIPEA and slowly transferred into a premixed solution of N-methoxycarbonyl- L-tert-leucine (35), HOBT, and WSC in DCM. After removal of the solvent the crude product was crystallized from IPA/EtOH to furnish the freebase 36 in 82% yield. The sulfate III was obtained by stirring the free base 36 with concentrated H2SO4 in EtOH at ambient temperature. Direct crystallization by addition of n-heptane provided the sulfate salt III as an easily filterable solid in 85% yield.

Atazanavir sulfate Preparation Products And Raw materials

Raw materials

Preparation Products

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Atazanavir sulfate Suppliers

Canada 1 China 225 Europe 2 India 32 South Africa 1 South Korea 1 Spain 1 United Kingdom 4 United States 22 Global 289
Changzhou Kangte Pharmtech Co.,Ltd
Tel
0519-82813797 18994752886
Fax
0519-82813703
Email
czkangte@hotmail.com
Country
China
ProdList
45
Advantage
62
Hubei Chenxin Pharmaceutical Co., Ltd.
Tel
18696113233
Fax
QQ:2544920688
Email
like1076463918@163.com
Country
China
ProdList
3055
Advantage
58
Shanghai Hanlin biology science and technology co., ltd
Tel
131-6639-0736
Email
1104939997@qq.com
Country
China
ProdList
2975
Advantage
58
Nanjing Yunzhi Xinhe Biotechnology Co., Ltd
Tel
19852363252 13151442052
Email
2634809846@qq.com
Country
China
ProdList
51
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Alabiochem Tech.Co., Ltd.
Tel
0512-58900862 400-0707518
Fax
0086-512-56765862
Email
sales@alabiochem.com
Country
China
ProdList
995
Advantage
59
Chembest Research Laboratories Limited
Tel
021-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6011
Advantage
61
Nanjing Habo Medical Technology Co., Ltd.
Tel
025-85760892 13376090521
Fax
025-85766769
Email
sales@habotech.com
Country
China
ProdList
999
Advantage
60
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2127
Advantage
70
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
17939
Advantage
64
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View Lastest Price from Atazanavir sulfate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Atazanavir sulfate 229975-97-7
Price
US $0.00-0.00/KG
Min. Order
100g
Purity
98%min
Supply Ability
50kg
Release date
2021-09-09
Shaanxi Dideu Medichem Co. Ltd
Product
Atazanavir sulfate 229975-97-7
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2020-05-07
Hebei Zhanyao Biotechnology Co. Ltd
Product
Atazanavir Sulfate 229975-97-7
Price
US $10.00/KG
Min. Order
1g
Purity
99%
Supply Ability
20 tons
Release date
2021-09-07

229975-97-7, Atazanavir sulfateRelated Search:

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