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Atazanavir sulfate

Product Name
Atazanavir sulfate
CAS No.
229975-97-7
Chemical Name
Atazanavir sulfate
Synonyms
Zrivada;Cgp 75355;Aids060276;Aids-060276;BMS-232632-05;BMS232632 sulfate;BMS 232632 sulfate;BMS-232632 sulfate;Atazanavir Sulfate;Atazanavir Sulphate
CBNumber
CB3547456
Molecular Formula
C38H52N6O7.H2SO4
Formula Weight
802.93
MOL File
229975-97-7.mol
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Atazanavir sulfate Property

Melting point:
195.0°, or acetone; mp 198-199° (dec)
alpha 
D22 -46.1° (c = 1 in 1:1 CH3OH/H2O, pH = 2.6)
storage temp. 
Inert atmosphere,2-8°C
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Safety

Safety Statements 
24/25
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
A790050
Product name
AtazanavirBisulfateSalt
Packaging
50mg
Price
$160
Updated
2021/12/16
Ark Pharm
Product number
P000492449
Product name
Atazanavir sulfate
Purity
98+%
Packaging
1g
Price
$30
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA29047
Product name
Atazanavir sulfate
Packaging
250 mg
Price
$120
Updated
2021/12/16
ChemScene
Product number
CS-1890
Product name
Atazanavir(sulfate)
Purity
99.94%
Packaging
50mg
Price
$144
Updated
2021/12/16
Ark Pharm
Product number
P000492449
Product name
Atazanavir sulfate
Purity
98+%
Packaging
10g
Price
$149
Updated
2021/12/16
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Atazanavir sulfate Chemical Properties,Usage,Production

Description

Atazanavir (BMS-232632, III), an azapeptide HIV protease inhibitor, has been developed and launched by Bristol-Myers Squibb (BMS), under worldwide license from Novartis, for the treatment of HIV infection. Atazanavir was launched in the US as Reyataz™ in July 2003.

Chemical Properties

Off-White Solid

Uses

Atazanavir is a novel azapeptide HIV protease inhibitor (PI). Antiviral.

Uses

Atazanavir is a HIV protease inhibitor with Ki of 2.66 nM

brand name

Reyataz (Bristol-Myers Squibb).

Chemical Synthesis

The synthesis of atazanavir (III) appeared in several reports. The synthetic route depicted in the scheme was one of the best routes which was suitable for large scale production. The commercially available chiral diol 25 was converted to its silyl mesylate 26 in one pot via selective silylation and subsequent mesylation. This oily intermediate 26 was carried into the next step without further purification. The desilylation of 26 was achieved by using inexpensive ammonium fluoride. The resulting solid product 27 was readily isolated and further purified through recrystallization from IPA/H2O in 80% yield. The epoxide formation from 27 was affected by KOtBu in THF/IPA to provide enantiomerically pure epoxide 28 in 88% yield. Suzuki coupling of boronic acid 29 with bromopyridine (30) provided pyridyl benzaldehyde 31 in 80% yield after crystallization. The subsequent condensation of aldehyde 31 with t-butylcarbamate was carried out by refluxing in toluene/IPA and Shiff base 32 was collected by filtration upon cooling. Reduction of hydrazone 32 to hydrazine 33 was accomplished by employing a catalytic phase-transfer hydrogenation protocol (Pd/C, HCOONa) to furnish hydrazine 33 in 78% yield after crystallization. Coupling of the hydrazinocarbamate 33 with epoxide 28 was performed in refluxing IPA, followed by the addition of water to precipitate the crude product. Subsequent recrystallization from MeCN/H2O furnished 34 in 85% yield. Treatment of 34 with concentrated HCl in THF at 50oC removed the two Boc groups in 34 to give the product as an oil, which was then dissolved in a mixture of DCM/DIPEA and slowly transferred into a premixed solution of N-methoxycarbonyl- L-tert-leucine (35), HOBT, and WSC in DCM. After removal of the solvent the crude product was crystallized from IPA/EtOH to furnish the freebase 36 in 82% yield. The sulfate III was obtained by stirring the free base 36 with concentrated H2SO4 in EtOH at ambient temperature. Direct crystallization by addition of n-heptane provided the sulfate salt III as an easily filterable solid in 85% yield.

Atazanavir sulfate Preparation Products And Raw materials

Raw materials

Preparation Products

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Atazanavir sulfate Suppliers

Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2560
Advantage
60
Changzhou Kangte Pharmtech Co.,Ltd
Tel
0519-82813797
Fax
0519-82813703
Email
czkangte@hotmail.com
Country
China
ProdList
45
Advantage
62
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Alabiochem Tech.Co., Ltd.
Tel
0512-58900862;0512-56727736
Fax
0086-512-56765862
Email
sales@alabiochem.com;sales@alabiochem.com
Country
China
ProdList
1005
Advantage
59
Chembest Research Laboratories Limited
Tel
021-20908456-
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
5947
Advantage
61
Nanjing Habo Medical Technology Co., Ltd.
Tel
025-85760892-
Fax
025-85766769
Email
sales@habotech.com;
Country
China
ProdList
1096
Advantage
60
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
1938
Advantage
70
Nanjing Chemlin Chemical Co., Ltd
Tel
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
20007
Advantage
64
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32358
Advantage
50
Jinan Trio PharmaTech Co., Ltd.
Tel
+86 (531) 88811783;
Fax
+86 (531) 55696010 QQ 1762738062
Email
sales@trio-pharmatech.com (International market);trio@trio-pharmatech.com(Domestic market)
Country
China
ProdList
1856
Advantage
62
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View Lastest Price from Atazanavir sulfate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Atazanavir sulfate 229975-97-7
Price
US $0.00-0.00/KG
Min. Order
100g
Purity
98%min
Supply Ability
50kg
Release date
2021-09-09
Hebei Zhanyao Biotechnology Co. Ltd
Product
Atazanavir Sulfate 229975-97-7
Price
US $10.00/KG
Min. Order
1g
Purity
99%
Supply Ability
20 tons
Release date
2021-09-07
Zhuozhou Wenxi import and Export Co., Ltd
Product
Atazanavir sulfate 229975-97-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

229975-97-7, Atazanavir sulfateRelated Search:


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