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2-CHLORO-3-(PIPERAZINYL)PYRAZINE

Product Name
2-CHLORO-3-(PIPERAZINYL)PYRAZINE
CAS No.
85386-99-8
Chemical Name
2-CHLORO-3-(PIPERAZINYL)PYRAZINE
Synonyms
2-Chloro-3-(piperazin-1-yl);2-CHLORO-3-(PIPERAZINYL)PYRAZINE;2-CHLORO-3-(1-PIPERAZINYL)PYRAZINE;Pyrazine, 2-chloro-3-(1-piperazinyl)-
CBNumber
CB91012005
Molecular Formula
C8H11ClN4
Formula Weight
198.65
MOL File
85386-99-8.mol
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2-CHLORO-3-(PIPERAZINYL)PYRAZINE Property

Boiling point:
342.7±42.0 °C(Predicted)
Density 
1.272±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
8.11±0.10(Predicted)
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Matrix Scientific
Product number
064515
Product name
2-Chloro-3-piperazin-1-ylpyrazine
Packaging
500.00mg
Price
$394
Updated
2026/05/18
aablocks
Product number
AA004TYR
Product name
2-Chloro-3-(1-piperazinyl)pyrazine
Purity
97%
Packaging
250mg
Price
$63
Updated
2026/05/28
aablocks
Product number
AA004TYR
Product name
2-Chloro-3-(1-piperazinyl)pyrazine
Purity
97%
Packaging
1g
Price
$140
Updated
2026/05/28
aablocks
Product number
AA004TYR
Product name
2-Chloro-3-(1-piperazinyl)pyrazine
Purity
97%
Packaging
5g
Price
$407
Updated
2026/05/28
aablocks
Product number
AA004TYR
Product name
2-Chloro-3-(1-piperazinyl)pyrazine
Purity
97%
Packaging
10g
Price
$674
Updated
2026/05/28
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2-CHLORO-3-(PIPERAZINYL)PYRAZINE Chemical Properties,Usage,Production

Synthesis

313654-83-0

85386-99-8

The general procedure for the synthesis of 2-chloro-3-piperazinopyrazine from tert-butyl 4-(3-chloropyrazin-2-yl)piperazine-1-carboxylate was as follows: tert-butyl 3'-chloro-2,3,5,6-tetrahydro-[1,2']bipyrazinyl-4-carboxylate (10 g, 33.4 mmol, 1 eq.) was dissolved in 1,4-dioxane (160 mL), and 4 M hydrochloric acid in 1,4- dioxane solution (80 mL, 0.3 mol, 10 eq.). The reaction mixture was stirred overnight at room temperature under nitrogen protection. Upon completion of the reaction, the reaction solution was diluted with dichloromethane (600 mL) and subsequently alkalized with 50% aqueous sodium hydroxide. The organic and aqueous layers were separated after addition of water (100 mL). The aqueous layer was extracted twice with dichloromethane (200 mL). All organic extracts were combined, washed with saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate, filtered and concentrated to give 3'-chloro-3,4,5,6-tetrahydro-2H-[1,2']bis(pyrazinyl) product as a viscous oil, which solidified on standing (6.39 g, 96% yield). Mass spectrum (electrospray ionization): m/z = 199.1, 201.1 [M + H]+.

References

[1] Patent: WO2009/29439, 2009, A1. Location in patent: Page/Page column 14
[2] Patent: WO2008/141020, 2008, A1. Location in patent: Page/Page column 64
[3] Patent: WO2009/48765, 2009, A1. Location in patent: Page/Page column 10
[4] Journal of Medicinal Chemistry, 2012, vol. 55, # 11, p. 5467 - 5482
[5] Patent: WO2017/21879, 2017, A1. Location in patent: Page/Page column 114-115

2-CHLORO-3-(PIPERAZINYL)PYRAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLORO-3-(PIPERAZINYL)PYRAZINE Suppliers

China 38 Germany 1 India 1 United Kingdom 1 United States 5 Global 46
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2338
Advantage
56
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
NovoChemy Ltd.
Tel
021-31261262/ 49 (0)17662837245
Fax
(0)21-33250524
Email
sales@novochemy.com
Country
Germany
ProdList
6328
Advantage
58
Shanghai Topbiochem Technology Co., Ltd
Tel
+86-21-60341587
Fax
+86-21-61294319
Email
sales@topbiochem.com
Country
China
ProdList
6175
Advantage
58
Nanjing Norris-Pharm Technology Co., Ltd
Tel
18652989687
Fax
+86-25-52131256
Email
sales@norris-pharm.com
Country
China
ProdList
8878
Advantage
55
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.
Tel
+86-28-85122536 85324413
Fax
+86-28-85326443
Email
market@astatech.cn
Country
China
ProdList
8026
Advantage
55
Cool Pharm, Ltd
Tel
021-60455363 18019463053
Fax
50966098
Email
sales@coolpharm.com
Country
China
ProdList
7250
Advantage
58
BePharm Ltd
Tel
400-685-9117
Fax
021-51816740
Email
market@bepharm.com
Country
China
ProdList
15081
Advantage
60
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Yantai ShengKailun Chemical Technology Co., Ltd.
Tel
13356901049
Fax
QQ：1025383091
Email
3119594100@qq.com
Country
China
ProdList
7964
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55

85386-99-8, 2-CHLORO-3-(PIPERAZINYL)PYRAZINERelated Search:

2-CHLORO-3-PIPERAZIN-1-YL-QUINOXALINE (3-CHLOROPHENYL)[4-(3-CHLOROQUINOXALIN-2-YL)PIPERAZINO]METHANONE N-(4-CHLOROPHENYL)-4-(3-CHLOROQUINOXALIN-2-YL)TETRAHYDROPYRAZINE-1(2H)-CARBOXAMIDE 2-CHLORO-3-(4-[(4-METHYLPHENYL)SULFONYL]PIPERAZINO)QUINOXALINE RARECHEM AL BO 2204 (4-CHLOROPHENYL)[4-(3-CHLOROQUINOXALIN-2-YL)PIPERAZINO]METHANONE N-(4-([4-(3-CHLOROQUINOXALIN-2-YL)PIPERAZINO]SULFONYL)PHENYL)ACETAMIDE 4-(3-CHLOROQUINOXALIN-2-YL)-N-PHENYLTETRAHYDROPYRAZINE-1(2H)-CARBOXAMIDE 2-CHLORO-3-(4-[(4-CHLORO-2,5-DIMETHYLPHENYL)SULFONYL]PIPERAZINO)QUINOXALINE [4-(3-CHLOROQUINOXALIN-2-YL)PIPERAZINO](3,5-DICHLOROPHENYL)METHANONE [4-(3-CHLOROQUINOXALIN-2-YL)PIPERAZINO](2-THIENYL)METHANONE 1-[4-(3-CHLOROQUINOXALIN-2-YL)PIPERAZINO]-2,2-DIMETHYLPROPAN-1-ONE 2-([4-(3-CHLOROQUINOXALIN-2-YL)PIPERAZINO]METHYLENE)MALONONITRILE [4-(3-CHLOROQUINOXALIN-2-YL)PIPERAZINO](PHENYL)METHANONE 2-CHLORO-3-(4-[(4-CHLOROPHENYL)SULFONYL]PIPERAZINO)QUINOXALINE 2-CHLORO-3-(4-[(2,4-DICHLORO-5-METHYLPHENYL)SULFONYL]PIPERAZINO)QUINOXALINE SALOR-INT L479233-1EA

  • 2-Chloro-3-(piperazin-1-yl)
  • 2-CHLORO-3-(PIPERAZINYL)PYRAZINE
  • 2-CHLORO-3-(1-PIPERAZINYL)PYRAZINE
  • Pyrazine, 2-chloro-3-(1-piperazinyl)-
  • 85386-99-8