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2-CHLORO-3-(PIPERAZINYL)PYRAZINE

Product Name
2-CHLORO-3-(PIPERAZINYL)PYRAZINE
CAS No.
85386-99-8
Chemical Name
2-CHLORO-3-(PIPERAZINYL)PYRAZINE
Synonyms
2-Chloro-3-(piperazin-1-yl);2-CHLORO-3-(PIPERAZINYL)PYRAZINE;2-CHLORO-3-(1-PIPERAZINYL)PYRAZINE;Pyrazine, 2-chloro-3-(1-piperazinyl)-
CBNumber
CB91012005
Molecular Formula
C8H11ClN4
Formula Weight
198.65
MOL File
85386-99-8.mol
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2-CHLORO-3-(PIPERAZINYL)PYRAZINE Property

Boiling point:
342.7±42.0 °C(Predicted)
Density 
1.272±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
8.11±0.10(Predicted)
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C350880
Product name
2-Chloro-3-(1-piperazinyl)pyrazine
Packaging
25mg
Price
$60
Updated
2021/12/16
TRC
Product number
C350880
Product name
2-Chloro-3-(1-piperazinyl)pyrazine
Packaging
50mg
Price
$100
Updated
2021/12/16
TRC
Product number
C350880
Product name
2-Chloro-3-(1-piperazinyl)pyrazine
Packaging
100mg
Price
$155
Updated
2021/12/16
Apolloscientific
Product number
OR911909
Product name
2-Chloro-3-(1-piperazinyl)pyrazine
Purity
95%
Packaging
250mg
Price
$225
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC123979
Product name
2-Chloro-3-piperazin-1-ylpyrazine
Packaging
500mg
Price
$250
Updated
2021/12/16
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2-CHLORO-3-(PIPERAZINYL)PYRAZINE Chemical Properties,Usage,Production

Synthesis

313654-83-0

85386-99-8

The general procedure for the synthesis of 2-chloro-3-piperazinopyrazine from tert-butyl 4-(3-chloropyrazin-2-yl)piperazine-1-carboxylate was as follows: tert-butyl 3'-chloro-2,3,5,6-tetrahydro-[1,2']bipyrazinyl-4-carboxylate (10 g, 33.4 mmol, 1 eq.) was dissolved in 1,4-dioxane (160 mL), and 4 M hydrochloric acid in 1,4- dioxane solution (80 mL, 0.3 mol, 10 eq.). The reaction mixture was stirred overnight at room temperature under nitrogen protection. Upon completion of the reaction, the reaction solution was diluted with dichloromethane (600 mL) and subsequently alkalized with 50% aqueous sodium hydroxide. The organic and aqueous layers were separated after addition of water (100 mL). The aqueous layer was extracted twice with dichloromethane (200 mL). All organic extracts were combined, washed with saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate, filtered and concentrated to give 3'-chloro-3,4,5,6-tetrahydro-2H-[1,2']bis(pyrazinyl) product as a viscous oil, which solidified on standing (6.39 g, 96% yield). Mass spectrum (electrospray ionization): m/z = 199.1, 201.1 [M + H]+.

References

[1] Patent: WO2009/29439, 2009, A1. Location in patent: Page/Page column 14
[2] Patent: WO2008/141020, 2008, A1. Location in patent: Page/Page column 64
[3] Patent: WO2009/48765, 2009, A1. Location in patent: Page/Page column 10
[4] Journal of Medicinal Chemistry, 2012, vol. 55, # 11, p. 5467 - 5482
[5] Patent: WO2017/21879, 2017, A1. Location in patent: Page/Page column 114-115

2-CHLORO-3-(PIPERAZINYL)PYRAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLORO-3-(PIPERAZINYL)PYRAZINE Suppliers

China 37 Germany 1 India 1 United Kingdom 1 United States 5 Global 45
TAIYUAN RHF CO.,LTD.
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+86 351 7031519
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+86 351 7031519
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sales@RHFChem.com
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China
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Pure Chemistry Scientific Inc.
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001-857-928-2050 or 1-888-588-9418
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001-617-206-9595
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sales@chemreagents.com
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United States
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NovoChemy Ltd.
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021-31261262/ 49 (0)17662837245
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(0)21-33250524
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sales@novochemy.com
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Germany
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Shanghai Topbiochem Technology Co., Ltd
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+86-21-60341587
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+86-21-61294319
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sales@topbiochem.com
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Nanjing Norris-Pharm Technology Co., Ltd
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18652989687
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+86-25-52131256
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Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.
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Cool Pharm, Ltd
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China
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BePharm Ltd
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400-685-9117
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Amadis Chemical Company Limited
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571-89925085
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0086-571-89925065
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Yantai ShengKailun Chemical Technology Co., Ltd.
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85386-99-8, 2-CHLORO-3-(PIPERAZINYL)PYRAZINERelated Search:

2-CHLORO-3-PIPERAZIN-1-YL-QUINOXALINE (3-CHLOROPHENYL)[4-(3-CHLOROQUINOXALIN-2-YL)PIPERAZINO]METHANONE N-(4-CHLOROPHENYL)-4-(3-CHLOROQUINOXALIN-2-YL)TETRAHYDROPYRAZINE-1(2H)-CARBOXAMIDE 2-CHLORO-3-(4-[(4-METHYLPHENYL)SULFONYL]PIPERAZINO)QUINOXALINE RARECHEM AL BO 2204 (4-CHLOROPHENYL)[4-(3-CHLOROQUINOXALIN-2-YL)PIPERAZINO]METHANONE N-(4-([4-(3-CHLOROQUINOXALIN-2-YL)PIPERAZINO]SULFONYL)PHENYL)ACETAMIDE 4-(3-CHLOROQUINOXALIN-2-YL)-N-PHENYLTETRAHYDROPYRAZINE-1(2H)-CARBOXAMIDE 2-CHLORO-3-(4-[(4-CHLORO-2,5-DIMETHYLPHENYL)SULFONYL]PIPERAZINO)QUINOXALINE [4-(3-CHLOROQUINOXALIN-2-YL)PIPERAZINO](3,5-DICHLOROPHENYL)METHANONE [4-(3-CHLOROQUINOXALIN-2-YL)PIPERAZINO](2-THIENYL)METHANONE 1-[4-(3-CHLOROQUINOXALIN-2-YL)PIPERAZINO]-2,2-DIMETHYLPROPAN-1-ONE 2-([4-(3-CHLOROQUINOXALIN-2-YL)PIPERAZINO]METHYLENE)MALONONITRILE [4-(3-CHLOROQUINOXALIN-2-YL)PIPERAZINO](PHENYL)METHANONE 2-CHLORO-3-(4-[(4-CHLOROPHENYL)SULFONYL]PIPERAZINO)QUINOXALINE 2-CHLORO-3-(4-[(2,4-DICHLORO-5-METHYLPHENYL)SULFONYL]PIPERAZINO)QUINOXALINE SALOR-INT L479233-1EA

  • 2-Chloro-3-(piperazin-1-yl)
  • 2-CHLORO-3-(PIPERAZINYL)PYRAZINE
  • 2-CHLORO-3-(1-PIPERAZINYL)PYRAZINE
  • Pyrazine, 2-chloro-3-(1-piperazinyl)-
  • 85386-99-8