4-Acetylamino-5-Chloro-2-Hydroxybenzoic Acid Methyl Ester
- Product Name
- 4-Acetylamino-5-Chloro-2-Hydroxybenzoic Acid Methyl Ester
- CAS No.
- 24190-77-0
- Chemical Name
- 4-Acetylamino-5-Chloro-2-Hydroxybenzoic Acid Methyl Ester
- Synonyms
- Prucalopride Impurity 36;Prucalopride Impurity 61;4-Acetylamino-5-Chloro-2-;Methyl 4-acetamido-5-chlorosalicylate;4-acetylamino-5-chloro-2-methoxybenzoate;4-acetylaMino-5-chloro-2-hydroxybenzoate;Methyl 5-chloro-4-acetaMido-2-hydroxybenzoate;Methyl 2-hydroxy-4-acetamido-5-chlorobenzoate;methyl 4-acetamido-2-hydroxy-5-chlorobenzoate;Methyl 4-acetylaMino-5-chloro-2-hdroxybenzoate
- CBNumber
- CB91013815
- Molecular Formula
- C10H10ClNO4
- Formula Weight
- 243.64
- MOL File
- 24190-77-0.mol
4-Acetylamino-5-Chloro-2-Hydroxybenzoic Acid Methyl Ester Property
- Melting point:
- 145-146℃
- Boiling point:
- 428.2±45.0 °C(Predicted)
- Density
- 1.426
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 8.87±0.23(Predicted)
- Appearance
- White to off-white Solid
N-Bromosuccinimide Price
- Product number
- M331213
- Product name
- Methyl4-Acetamido-5-chloro-2-hydroxybenzoate
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- M331213
- Product name
- Methyl4-Acetamido-5-chloro-2-hydroxybenzoate
- Packaging
- 500mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- W4773
- Product name
- 4-Acetylamino-5-Chloro-2-HydroxybenzoicacidMethylEster
- Packaging
- 10g
- Price
- $207
- Updated
- 2021/12/16
- Product number
- 073939
- Product name
- Methyl 4-acetylamino-5-chloro-2-hydroxybenzoate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $231
- Updated
- 2021/12/16
- Product number
- 073939
- Product name
- Methyl 4-acetylamino-5-chloro-2-hydroxybenzoate
- Purity
- 95+%
- Packaging
- 5g
- Price
- $639
- Updated
- 2021/12/16
4-Acetylamino-5-Chloro-2-Hydroxybenzoic Acid Methyl Ester Chemical Properties,Usage,Production
Synthesis
4093-28-1
24190-77-0
Methyl 4-acetamido-2-hydroxybenzoate (61.4 g, 294.0 mmol) was dissolved with stirring in dichloroethane (1.2 L) followed by the addition of N-chlorosuccinimide (58.8 g, 441 mmol). The reaction mixture was heated to reflux for 3 hours. Upon completion of the reaction, the volatile solvent was removed by distillation under reduced pressure. Water (1.0 liter) was added to the residue to precipitate the solid product, which was collected by filtration. The crude product was dissolved in a solvent mixture of methanol and dichloromethane (1:9 v/v) and washed with saturated brine. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford methyl 4-acetamido-5-chloro-2-hydroxybenzoate (67.7 g) in 94.6% yield. The structure of the product was confirmed by nuclear magnetic resonance hydrogen spectroscopy (DMSO-d6): δ 10.49 (broad single peak, 1H), 9.47 (single peak, 1H), 7.75 (single peak, 1H), 7.72 (single peak, 1H), 3.85 (single peak, 3H), 2.16 (single peak, 3H); mass spectrometry analysis showed the molecular ion peaks (m/z) to be 244 and 246 (M+H)+.
References
[1] Patent: WO2013/42135, 2013, A1. Location in patent: Page/Page column 11
[2] Patent: US2014/187581, 2014, A1. Location in patent: Paragraph 0098-0100
[3] Patent: WO2016/128990, 2016, A1. Location in patent: Page/Page column 26-27
[4] Bioorganic and Medicinal Chemistry Letters, 1996, vol. 6, # 22, p. 2657 - 2662
[5] Patent: CN107337658, 2017, A. Location in patent: Paragraph 0043; 0044
4-Acetylamino-5-Chloro-2-Hydroxybenzoic Acid Methyl Ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Acetylamino-5-Chloro-2-Hydroxybenzoic Acid Methyl Ester manufacturers
- Product
- 4-Acetylamino-5-Chloro-2-Hydroxybenzoic Acid Methyl Ester 24190-77-0
- Price
- US $1.00/kg
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2018-12-21