Methyl 3-hydroxy-4-nitrobenzoate
Application- Product Name
- Methyl 3-hydroxy-4-nitrobenzoate
- CAS No.
- 713-52-0
- Chemical Name
- Methyl 3-hydroxy-4-nitrobenzoate
- Synonyms
- TIMTEC-BB SBB002401;RARECHEM AL BF 0673;Vibegron Impurity 10;3-HYDROXY-4-NITROMETHYLBENZOATE;METHYL 3-HYDROXY-4-NITROBENZOATE;Methyl3-Hydroxy-4-nitrobenzoate>Methyl3-hydroxy-4-nitrobenzoate,98%;4-Nitro-3-hydroxybenzoic acid methyl ester;3-HYDROXY-4-NITROBENZOIC ACID METHYL ESTER;Benzoic acid, 3-hydroxy-4-nitro-, Methyl ester
- CBNumber
- CB9101827
- Molecular Formula
- C8H7NO5
- Formula Weight
- 197.14
- MOL File
- 713-52-0.mol
Methyl 3-hydroxy-4-nitrobenzoate Property
- Melting point:
- 90-91°C
- Boiling point:
- 346.4±27.0 °C(Predicted)
- Density
- 1.432±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- form
- powder to crystal
- pka
- 6.05±0.13(Predicted)
- color
- Light yellow to Amber to Dark green
- BRN
- 2583832
- CAS DataBase Reference
- 713-52-0(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- Hazard Note
- Irritant
- HS Code
- 2918290090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- M2250
- Product name
- Methyl 3-Hydroxy-4-nitrobenzoate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $71
- Updated
- 2025/07/31
- Product number
- M2250
- Product name
- Methyl 3-Hydroxy-4-nitrobenzoate
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $237
- Updated
- 2025/07/31
- Product number
- M323468
- Product name
- Methyl 3-Hydroxy-4-nitrobenzoate
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- J94962
- Product name
- Methyl 3-Hydroxy-4-nitrobenzoate
- Packaging
- 5g
- Price
- $14
- Updated
- 2021/12/16
- Product number
- X4614
- Product name
- Methyl 3-Hydroxy-4-nitrobenzoate
- Packaging
- 5g
- Price
- $19
- Updated
- 2021/12/16
Methyl 3-hydroxy-4-nitrobenzoate Chemical Properties,Usage,Production
Application
Methyl 3-hydroxy-4-nitrobenzoate is an organic intermediate that can be obtained by esterification of 3-hydroxy-4-nitrobenzoic acid. It can be used as an organic synthesis intermediate and a pharmaceutical intermediate, and is mainly used in laboratory research and development processes and chemical production processes.
Synthesis
67-56-1
619-14-7
713-52-0
Concentrated sulfuric acid (0.5 mL) was slowly added dropwise to a solution of 3-hydroxy-4-nitrobenzoic acid (1.88 g, 10.3 mmol) dissolved in undried HPLC-grade methanol (60 mL), and the reaction mixture was subsequently heated to reflux for 18 hours. Upon completion of the reaction, sodium bicarbonate was added to the reaction solution to neutralize the acidity, followed by evaporation of the solvent under reduced pressure. To the residue, water and ethyl acetate were added for extraction and the aqueous layer was separated. The aqueous layer was further extracted five times with ethyl acetate. All organic layers were combined, washed twice with saturated brine, dried over anhydrous magnesium sulfate, and finally concentrated under reduced pressure to remove the solvent to give methyl 3-hydroxy-4-nitrobenzoate as yellow crystals with a yield of 2.00 g (99% yield) and a melting point of 89.5-90.5°C (literature values: 86-88°C, 91-92°C). UV spectrum (methanol): λmax = 238, 270, 351 nm. infrared spectrum (ATR): ν = 3310, 3124, 3050, 2962, 2842, 1720, 1622, 1587, 1521, 1476, 1434, 1323, 1283, 1222, 1147, 1098, 1067, 967, 891, 843, 798, 780, 743, 666 cm-1.1H NMR (500 MHz, CDCl3): δ=3.96 (s, 3H), 7.61 (dd, J=8.8, 1.7 Hz, 1H), 7.83 (d, J=1.7 Hz, 1H), 8.17 (d, J=8.8 Hz, 1H), 10.50 (s , 1H).13C NMR and DEPT (125 MHz, CDCl3): δ = 53.08 (CH3), 120.73 (CH), 121.80 (CH), 125.41 (CH), 135.90 (C), 138.10 (C), 154.79 (C), 164.97 (C=O). Mass spectrum (ESI, -10V): m/z=196 ([M-H]-). Calculated elemental analysis (C8H7NO5): C 48.74%, H 3.58%, N 7.10%; measured values: C 48.58%, H 3.44%, N 7.25%.
References
[1] Synlett, 2008, # 11, p. 1698 - 1702
[2] Organic and Biomolecular Chemistry, 2012, vol. 10, # 15, p. 2928 - 2933
[3] Synlett, 2015, vol. 26, # 9, p. 1175 - 1178
[4] Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 24, p. 8219 - 8248
[5] Tetrahedron, 2012, vol. 68, # 33, p. 6727 - 6736
Methyl 3-hydroxy-4-nitrobenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
Methyl 3-hydroxy-4-nitrobenzoate Suppliers
- Tel
- 03-36680489
- Fax
- 03-3668-0520
- Sales-JP@TCIchemicals.com
- Country
- Japan
- ProdList
- 28387
- Advantage
- 80
View Lastest Price from Methyl 3-hydroxy-4-nitrobenzoate manufacturers
- Product
- Methyl 3-hydroxy-4-nitrobenzoate 713-52-0
- Price
- US $100.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-25
- Product
- Methyl 3-hydroxy-4-nitrobenzoate 713-52-0
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 100 tons
- Release date
- 2020-01-10
- Product
- Methyl 3-hydroxy-4-nitrobenzoate 713-52-0
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2018-12-18