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Zidapamide

Product Name
Zidapamide
CAS No.
75820-08-5
Chemical Name
Zidapamide
Synonyms
Zidapamide;ZIDAPUMIDE;Isodapamide;4-Chloro-N-(1-methyl-1,3-dihydroisoindol-2-yl)-3-sulfamoylbenzamide;4-Chloro-N-(1,3-dihydro-1-methyl-2H-isoindol-2-yl)-3-sulfamoylbenzamide;3-(Aminosulfonyl)-4-chloro-N-(1,3-dihydro-1-methyl-2H-isoindol-2-yl)benzamide;Benzamide, 3-(aminosulfonyl)-4-chloro-N-(1,3-dihydro-1-methyl-2H-isoindol-2-yl)-
CBNumber
CB9103700
Molecular Formula
C16H16ClN3O3S
Formula Weight
365.83
MOL File
75820-08-5.mol
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0012819
Product name
ZIDAPAMIDE
Purity
95.00%
Packaging
5MG
Price
$503.44
Updated
2021/12/16
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Zidapamide Chemical Properties,Usage,Production

Originator

Zidapamide,ZYF Pharm Chemical

Uses

Zidapamide is a thiazide-like diuretic drug used in treatment of hypertension.

Manufacturing Process

5.6 ml of triethylamine are added to a solution of 5.0 g (0.018 m) of α- methyl-α,α-dibromo-o-xylene and 2.38 g (0.018 m) of t-butylcarbazate in 15 ml of dimethylformamide heated to 50-60°C. After the addition, the mixture is left stirring for 3 h at room temperature, the solution volume is then made up to about 60 ml by diluting with H 2 O and the solution is left for a further hour under stirring. The solid which separates is filtered off, washed with water and dried to give 3.14 g (70%) of 1-methyl-N-(t-butyloxycarbonylamino) isoindoline, melting point 143-145°C.
A suspension of 2.6 g (0.0104 m) of the 1-methyl-N-(t- butyloxycarbonylamino)isoindoline in 7 ml of concentrated HCl is kept stirring at room temperature for 1 h. The final solution is evaporated to dryness under vacuum by heating to 60-70°C to give a solid residue (1.97 g) which crystalises from EtOH+Et 2 O (1/1) to give 1.5 g (77.6%) of 1-methyl-2-amine isoindoline hydrochloride, melting point 140-145°C.
3.44 g (0.0 135 m) of 4-chloro-3-sulfamidobenzoic acid chloride are added to a solution of 2.5 g (0.0135 m) of 1-methyl-2-aminoisoindoline hydrochloride and 3.5 g (0.0314 m) of triethylamine in 30 ml of tetrahydrofuran. The mixture is kept stirring at room temperature for 15 h. The abundant solid which separates is filtered off, and is suspended in water in order to remove the triethylamine hydrochloride present. The residue is collected by filtration and dried in a drier to give 3.0 g of 1-methyl-2-(3'-sulfamyl-4'- chlorobenzamido)isoindoline, melting point 208-210°C (the analytical sample crystallizes from 10 volumes of ethyl alcohol, and has a melting point of 210- 212°C).
A further amount (0.4 g) of product can be isolated by evaporating the tetrahydrofuran reaction solution, mixing the oily residue with ethyl alcohol and allowing it to crystallize in a refrigerator. The overall yield is 3.4 g, equal to 68.6%.

Therapeutic Function

Antihypertensive

Zidapamide Preparation Products And Raw materials

Raw materials

Preparation Products

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Zidapamide Suppliers

Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
Hubei Yangxin Medical Technology Co., Ltd.
Tel
15374522761
Fax
QQ:2853117752
Email
3003392093@qq.com
Country
China
ProdList
8376
Advantage
55
CONIER CHEM AND PHARMA LIMITED
Tel
+8618523575427
Email
sales@conier.com
Country
China
ProdList
49374
Advantage
58
Suchem Pharma Co., Ltd.
Tel
--
Fax
--
Country
China
ProdList
79
Advantage
50
Shanghai Chemfrom Chemical Co., Ltd
Tel
--
Fax
--
Country
China
ProdList
65
Advantage
30
Lanospharma Laboratories Co.,Ltd
Tel
--
Fax
--
Email
sales@lanospharma.com
Country
China
ProdList
6329
Advantage
56
Advanced Technology & Industrial Co., Ltd.
Tel
--
Fax
--
Email
sales@advtechind.com
Country
China
ProdList
6523
Advantage
75

75820-08-5, ZidapamideRelated Search:


  • ZIDAPUMIDE
  • Zidapamide
  • 3-(Aminosulfonyl)-4-chloro-N-(1,3-dihydro-1-methyl-2H-isoindol-2-yl)benzamide
  • 4-Chloro-N-(1,3-dihydro-1-methyl-2H-isoindol-2-yl)-3-sulfamoylbenzamide
  • Isodapamide
  • 4-Chloro-N-(1-methyl-1,3-dihydroisoindol-2-yl)-3-sulfamoylbenzamide
  • Benzamide, 3-(aminosulfonyl)-4-chloro-N-(1,3-dihydro-1-methyl-2H-isoindol-2-yl)-
  • 75820-08-5