ChemicalBook > CAS DataBase List > 2-Amino-3-bromo-5-methylpyrazine

2-Amino-3-bromo-5-methylpyrazine

Product Name: 2-Amino-3-bromo-5-methylpyrazine
CAS No.: 74290-65-6
Chemical Name: 2-Amino-3-bromo-5-methylpyrazine
Synonyms: 3-bromo-5-methylpyrazin-2-amine;3-broMo-5-Methylpyrazin-2-Mine;2-Amino-3-bromo-5-methylpyrazine;3-Bromo 5-Methyl pyrazine-2-amine;2-PyrazinaMine, 3-broMo-5-Methyl-;3-Bromo-5-methylpyrazin-2-ylamine
CBNumber: CB91074395
Molecular Formula: C5H6BrN3
Formula Weight: 188.03
MOL File: 74290-65-6.mol

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2-Amino-3-bromo-5-methylpyrazine Property

Melting point:: 56-57 °C
Boiling point:: 275.0±35.0 °C(Predicted)
Density: 1.699±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 2.65±0.10(Predicted)
Appearance: Off-white to light yellow Solid

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Safety

HazardClass: IRRITANT
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: A594595
Product name: 2-Amino-3-bromo-5-methylpyrazine
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA147792
Product name: 2-Amino-3-bromo-5-methylpyrazine
Packaging: 100mg
Price: $63
Updated: 2021/12/16

AK Scientific

Product number: W8202
Product name: 2-Amino-3-bromo-5-methylpyrazine
Packaging: 100mg
Price: $77
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA147792
Product name: 2-Amino-3-bromo-5-methylpyrazine
Packaging: 250mg
Price: $125
Updated: 2021/12/16

Matrix Scientific

Product number: 057892
Product name: 2-Amino-3-bromo-5-methylpyrazine
Purity: 95%
Packaging: 500mg
Price: $185
Updated: 2021/12/16

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2-Amino-3-bromo-5-methylpyrazine Chemical Properties,Usage,Production

Synthesis

5521-58-4

74290-65-6

General procedure for the synthesis of 2-amino-3-bromo-5-methylpyrazine from 2-amino-5-methylpyrazine: Bromine (8.80 g, 55.0 mmol) was slowly added to a solution of dichloromethane (250 mL) containing 5-methylpyrazin-2-amine (5.00 g, 45.8 mmol) and pyridine (4.35 g, 55.0 mmol). The reaction mixture was stirred overnight at room temperature. Upon completion of the reaction, water (150 mL) was added to the mixture for extraction and the organic layer was separated. The organic layer was washed with saturated brine (100 mL), dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated under vacuum to afford the target compound 2-amino-3-bromo-5-methylpyrazine as a yellow solid (7.64 g, 88% yield). Mass spectrum (ESI, positive ion mode) m/z: 190.2 [M + H]+; 1H NMR (400 MHz, CDCl3) δ (ppm): 7.83 (s, 1H), 4.93 (s, 2H), 2.41 (s, 3H).

References

[1] Patent: WO2018/108125, 2018, A1. Location in patent: Paragraph 00511
[2] Patent: WO2018/136265, 2018, A1. Location in patent: Paragraph 00790
[3] Patent: US2014/275531, 2014, A1. Location in patent: Paragraph 0353
[4] Patent: JP5714745, 2015, B2. Location in patent: Paragraph 0687; 0688
[5] Patent: US5866568, 1999, A

2-Amino-3-bromo-5-methylpyrazine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Amino-3-bromo-5-methylpyrazine manufacturers

Career Henan Chemical Co

Product: 2-Amino-3-bromo-5-methylpyrazine 74290-65-6
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-10

74290-65-6, 2-Amino-3-bromo-5-methylpyrazineRelated Search:

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74290-65-6

Halides

Pyrazines, Pyrimidines & Pyridazines