2-Amino-3-bromo-5-methylpyrazine
- Product Name
- 2-Amino-3-bromo-5-methylpyrazine
- CAS No.
- 74290-65-6
- Chemical Name
- 2-Amino-3-bromo-5-methylpyrazine
- Synonyms
- 3-bromo-5-methylpyrazin-2-amine;3-broMo-5-Methylpyrazin-2-Mine;2-Amino-3-bromo-5-methylpyrazine;3-Bromo 5-Methyl pyrazine-2-amine;2-PyrazinaMine, 3-broMo-5-Methyl-;3-Bromo-5-methylpyrazin-2-ylamine
- CBNumber
- CB91074395
- Molecular Formula
- C5H6BrN3
- Formula Weight
- 188.03
- MOL File
- 74290-65-6.mol
2-Amino-3-bromo-5-methylpyrazine Property
- Melting point:
- 56-57 °C
- Boiling point:
- 275.0±35.0 °C(Predicted)
- Density
- 1.699±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 2.65±0.10(Predicted)
- Appearance
- Off-white to light yellow Solid
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A594595
- Product name
- 2-Amino-3-bromo-5-methylpyrazine
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FA147792
- Product name
- 2-Amino-3-bromo-5-methylpyrazine
- Packaging
- 100mg
- Price
- $63
- Updated
- 2021/12/16
- Product number
- W8202
- Product name
- 2-Amino-3-bromo-5-methylpyrazine
- Packaging
- 100mg
- Price
- $77
- Updated
- 2021/12/16
- Product number
- FA147792
- Product name
- 2-Amino-3-bromo-5-methylpyrazine
- Packaging
- 250mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- 057892
- Product name
- 2-Amino-3-bromo-5-methylpyrazine
- Purity
- 95%
- Packaging
- 500mg
- Price
- $185
- Updated
- 2021/12/16
2-Amino-3-bromo-5-methylpyrazine Chemical Properties,Usage,Production
Synthesis
5521-58-4
74290-65-6
General procedure for the synthesis of 2-amino-3-bromo-5-methylpyrazine from 2-amino-5-methylpyrazine: Bromine (8.80 g, 55.0 mmol) was slowly added to a solution of dichloromethane (250 mL) containing 5-methylpyrazin-2-amine (5.00 g, 45.8 mmol) and pyridine (4.35 g, 55.0 mmol). The reaction mixture was stirred overnight at room temperature. Upon completion of the reaction, water (150 mL) was added to the mixture for extraction and the organic layer was separated. The organic layer was washed with saturated brine (100 mL), dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated under vacuum to afford the target compound 2-amino-3-bromo-5-methylpyrazine as a yellow solid (7.64 g, 88% yield). Mass spectrum (ESI, positive ion mode) m/z: 190.2 [M + H]+; 1H NMR (400 MHz, CDCl3) δ (ppm): 7.83 (s, 1H), 4.93 (s, 2H), 2.41 (s, 3H).
References
[1] Patent: WO2018/108125, 2018, A1. Location in patent: Paragraph 00511
[2] Patent: WO2018/136265, 2018, A1. Location in patent: Paragraph 00790
[3] Patent: US2014/275531, 2014, A1. Location in patent: Paragraph 0353
[4] Patent: JP5714745, 2015, B2. Location in patent: Paragraph 0687; 0688
[5] Patent: US5866568, 1999, A
2-Amino-3-bromo-5-methylpyrazine Preparation Products And Raw materials
Raw materials
Preparation Products
2-Amino-3-bromo-5-methylpyrazine Suppliers
- Tel
- 021-31261262/ 49 (0)17662837245
- Fax
- (0)21-33250524
- sales@novochemy.com
- Country
- Germany
- ProdList
- 6328
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@chemos-group.com
- Country
- Germany
- ProdList
- 6350
- Advantage
- 71
View Lastest Price from 2-Amino-3-bromo-5-methylpyrazine manufacturers
- Product
- 2-Amino-3-bromo-5-methylpyrazine 74290-65-6
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-10