PMPA(NAALADaseinhibitor)

Product Name: PMPA(NAALADaseinhibitor)
CAS No.: 173039-10-6
Chemical Name: PMPA(NAALADaseinhibitor)
Synonyms: 2-PMPA;CS-2454;NAALADASEINHIBITOR;PMPA(NAALADaseinhibitor);2-PMPA(NAALADaseinhibitor);Pentanedioic acid, 2-(phosphonomethyl)-;2-(Phosphonomethyl)pentane-1,5-dioicacid;2-(PHOSPHONOMETHYL)PENTANEDIOIC ACID (PMPA);inhibit,Inhibitor,2PMPA,Carboxypeptidase,2-PMPA,2 PMPA
CBNumber: CB91075110
Molecular Formula: C6H11O7P
Formula Weight: 226.12
MOL File: 173039-10-6.mol

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PMPA(NAALADaseinhibitor) Property

Boiling point:: 538.8±60.0 °C(Predicted)
Density: 1.658±0.06 g/cm3(Predicted)
storage temp.: room temp
solubility: Soluble to 100 mM in sterile
form: powder
pka: 2.06±0.10(Predicted)
color: white to beige
Water Solubility: Soluble to 100 mM in water

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Safety

RTECS: SA0454800

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1612
Product name: 2-PMPA
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $117
Updated: 2023/06/20

Sigma-Aldrich

Product number: SML1612
Product name: 2-PMPA
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $478
Updated: 2023/06/20

Cayman Chemical

Product number: 21916
Product name: 2-(Phosphonomethyl)-pentanedioic Acid
Purity: ≥95%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 21916
Product name: 2-(Phosphonomethyl)-pentanedioic Acid
Purity: ≥95%
Packaging: 5mg
Price: $100
Updated: 2024/03/01

Cayman Chemical

Product number: 21916
Product name: 2-(Phosphonomethyl)-pentanedioic Acid
Purity: ≥95%
Packaging: 10mg
Price: $139
Updated: 2024/03/01

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PMPA(NAALADaseinhibitor) Chemical Properties,Usage,Production

Uses

2-(Phosphonomethyl)pentanedioic Acid is a selective glutamate carboxypeptidase 2 (GCP-II) inhibitor, the enzyme which catabolizes the abundant neuropeptide N-acetyl-aspartyl-glutamate (NAAG) to N-acetylaspartate (NAA) and glutamate. A posiible target in the treatment of multiple sclerosis and Schizophrenia.

Biological Activity

Highly potent and selective inhibitor of? glutamate carboxypeptidase 2 (GCP II/N-acetylated α -linked dipeptidase/NAALADase) with a K i value of 275 pM. Neuroprotective; protects against glutamate-mediated motor neuron degeneration and reduces volume of injury following middle cerebral artery occlusion (MCAO).

Biochem/physiol Actions

2-PMPA is a potent and selective inhibitor of Glutamate carboxypeptidase II (GCPII).

storage

Desiccate at RT

PMPA(NAALADaseinhibitor) Preparation Products And Raw materials

Raw materials

Preparation Products

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PMPA(NAALADaseinhibitor) Suppliers

China 59 Germany 1 India 1 United Kingdom 1 United States 9 Global 71

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173039-10-6, PMPA(NAALADaseinhibitor)Related Search:

3-PHOSPHONOPROPIONIC ACID 5-PHOSPHONOPENTANOIC ACID PMPA(NAALADaseinhibitor)

PMPA(NAALADaseinhibitor)

2-(Phosphonomethyl)pentane-1,5-dioicacid

2-PMPA

CS-2454

2-PMPA(NAALADaseinhibitor)

NAALADASEINHIBITOR

Pentanedioic acid, 2-(phosphonomethyl)-

2-(PHOSPHONOMETHYL)PENTANEDIOIC ACID (PMPA)

inhibit,Inhibitor,2PMPA,Carboxypeptidase,2-PMPA,2 PMPA

173039-10-6