ChemicalBook > CAS DataBase List > PMPA(NAALADaseinhibitor)
PMPA(NAALADaseinhibitor)
- Product Name
- PMPA(NAALADaseinhibitor)
- CAS No.
- 173039-10-6
- Chemical Name
- PMPA(NAALADaseinhibitor)
- Synonyms
- 2-PMPA;CS-2454;NAALADASEINHIBITOR;PMPA(NAALADaseinhibitor);2-PMPA(NAALADaseinhibitor);Pentanedioic acid, 2-(phosphonomethyl)-;2-(Phosphonomethyl)pentane-1,5-dioicacid;2-(PHOSPHONOMETHYL)PENTANEDIOIC ACID (PMPA);inhibit,Inhibitor,2PMPA,Carboxypeptidase,2-PMPA,2 PMPA
- CBNumber
- CB91075110
- Molecular Formula
- C6H11O7P
- Formula Weight
- 226.12
- MOL File
- 173039-10-6.mol
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PMPA(NAALADaseinhibitor) Property
- Boiling point:
- 538.8±60.0 °C(Predicted)
- Density
- 1.658±0.06 g/cm3(Predicted)
- storage temp.
- room temp
- solubility
- Soluble to 100 mM in sterile
- form
- powder
- pka
- 2.06±0.10(Predicted)
- color
- white to beige
- Water Solubility
- Soluble to 100 mM in water
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Safety
- RTECS
- SA0454800
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML1612
- Product name
- 2-PMPA
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $117
- Updated
- 2023/06/20
Sigma-Aldrich
- Product number
- SML1612
- Product name
- 2-PMPA
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $478
- Updated
- 2023/06/20
Cayman Chemical
- Product number
- 21916
- Product name
- 2-(Phosphonomethyl)-pentanedioic Acid
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 21916
- Product name
- 2-(Phosphonomethyl)-pentanedioic Acid
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $100
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 21916
- Product name
- 2-(Phosphonomethyl)-pentanedioic Acid
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $139
- Updated
- 2024/03/01
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PMPA(NAALADaseinhibitor) Chemical Properties,Usage,Production
Uses
2-(Phosphonomethyl)pentanedioic Acid is a selective glutamate carboxypeptidase 2 (GCP-II) inhibitor, the enzyme which catabolizes the abundant neuropeptide N-acetyl-aspartyl-glutamate (NAAG) to N-acetylaspartate (NAA) and glutamate. A posiible target in the treatment of multiple sclerosis and Schizophrenia.
Biological Activity
Highly potent and selective inhibitor of? glutamate carboxypeptidase 2 (GCP II/N-acetylated α -linked dipeptidase/NAALADase) with a K i value of 275 pM. Neuroprotective; protects against glutamate-mediated motor neuron degeneration and reduces volume of injury following middle cerebral artery occlusion (MCAO).
Biochem/physiol Actions
2-PMPA is a potent and selective inhibitor of Glutamate carboxypeptidase II (GCPII).
storage
Desiccate at RT
PMPA(NAALADaseinhibitor) Preparation Products And Raw materials
Raw materials
Preparation Products
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