N-Acetylcysteine amide

Product Name: N-Acetylcysteine amide
CAS No.: 38520-57-9
Chemical Name: N-Acetylcysteine amide
Synonyms: AD4;NACA;100951;acetylcysteinamide;N-ACETYL-L-CYSTINE;N-acetylcysteine amide;N-Acetyl-L-cysteinamide;N-acetyl-L-Cysteine amide;Acetylcysteine Impurity 14;(R)-2-acetaMido-3-MercaptopropanaMide
CBNumber: CB91092625
Molecular Formula: C5H10N2O2S
Formula Weight: 162.21
MOL File: 38520-57-9.mol

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N-Acetylcysteine amide Property

Melting point:: 147-149 °C(Solv: ethanol (64-17-5))
Boiling point:: 441.0±40.0 °C(Predicted)
Density: 1.226±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: H2O: ≥20mg/mL
pka: 9.21±0.10(Predicted)
form: lyophilized powder
color: white to off-white
InChI: InChI=1S/C5H10N2O2S/c1-3(8)7-4(2-10)5(6)9/h4,10H,2H2,1H3,(H2,6,9)(H,7,8)/t4-/m0/s1
InChIKey: ZLCOWUKVVFVVKA-GDVGLLTNSA-N
SMILES: C(N)(=O)[C@@H](NC(C)=O)CS

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A0737
Product name: N-acetylcysteine amide
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $140
Updated: 2024/03/01

Sigma-Aldrich

Product number: A0737
Product name: N-acetylcysteine amide
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $333.6
Updated: 2024/03/01

Cayman Chemical

Product number: 25866
Product name: N-acetyl-L-Cysteine amide
Packaging: 5mg
Price: $82
Updated: 2024/03/01

Cayman Chemical

Product number: 25866
Product name: N-acetyl-L-Cysteine amide
Packaging: 50mg
Price: $601
Updated: 2024/03/01

Cayman Chemical

Product number: 25866
Product name: N-acetyl-L-Cysteine amide
Packaging: 10mg
Price: $145
Updated: 2024/03/01

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N-Acetylcysteine amide Chemical Properties,Usage,Production

Uses

N-acetylcysteine amide has been used:

to protect retinal pigment epithelium (RPE) from oxidative stress
to show that increased expression of cell adhesion molecule 4 (CADM4) in oligodendrocytes inhibits myelination
to protect cells from apoptosis induced by shikonin plus erlotinib/gefitinib
as a component in various culture media

Preparation

N-Acetyl-L-cysteine methyl ester (10 g) under a flush of nitrogen was treated with ammonium hydroxide (28% aqueous, 66 mL) over 10 minutes at room temperature and stirred for 6 hours. The resulting solution was concentrated in vacuo and ethanol (100 mL) was added. Then the solution was concentrated again under reduced pressure at 48 00 then subjected to high vacuum overnight to afford N-acetylcysteine amide as a white crystalline solid.

Biochem/physiol Actions

N-acetylcysteine amide is a membrane penetrating antioxidant with antiinflamatory activity through regulation of activation of NF-κB and HIF-1α as well as modulation of ROS. The compound readily crosses cell membranes, replenishes intracellular GSH, and defends the cell from oxidative stress. In contrast to DTT, AD4 is able to directly reduce intracellularl GSSG to GSH without the involvement of glutathione peroxidase. Such direct thiol exchange might have a protective effect. This compound has a potential in research and exploration for treatment of neurodegeneration, radiation exposure, and other oxidation-mediated disorders.

Clinical Use

N-Acetylcysteine amide has antioxidant and is often used in the preparation of Eyedrops. It has been used as a treatment for the prevention or healing of cataracts, macular degeneration, and other degenerative eye disorders.

storage

Store at -20°C

N-Acetylcysteine amide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Acetylcysteine amide Suppliers

China 80 Germany 1 India 1 Japan 1 United Kingdom 1 United States 10 Global 94

Wuxi Donghe Pharmaceutical Technology Co., Ltd.

Tel: 63313187 15358055255
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Shandong Jirun Biomedical Technology Co., Ltd.

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Country: China
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Country: Germany
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Shanghai Kewel Chemical Co., Ltd.

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Sigma-Aldrich

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BOC Sciences

Tel: 16314854226
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Country: United States
ProdList: 9926
Advantage: 65

38520-57-9, N-Acetylcysteine amideRelated Search:

Magnesium trisilicate L-Cystine

N-ACETYL-L-CYSTINE

(R)-2-acetaMido-3-MercaptopropanaMide

PropanaMide,2-(acetylaMino)-3-Mercapto-, (2R)-

N-Acetylcysteine amide Synonyms N-Acetyl-L-cysteinamide

(R)- 2-(Acetylamino)-3-mercapto-Propanamide

acetylcysteinamide

AD4

(2R)-2-acetamido-3-sulfanylpropanamide

NACA

N-acetylcysteine amide

N-Acetyl-L-cysteinamide

100951

(2R)-2-(Acetylamino)-3-mercaptopropanamide

N-acetyl-L-Cysteine amide

Acetylcysteine Impurity 14

(2S)-2-acetamido-3-sulfanylpropanamide

Nacetylcysteine amide,N acetylcysteine amide,Reactive Oxygen Species,inhibit,N-Acetylcysteine amide,Inhibitor

38520-57-9

C8H14N2O5S2