2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene

Product Name: 2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene
CAS No.: 172900-69-5
Chemical Name: 2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene
Synonyms: -1-methoxybenzene;2-(3-Methoxypropoxy);2-(3-Methoxypropoxy)-4-((R)-2-(broMoMethyl)-3;2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1...;4-(5-bromo-4-methylpentyl)-1-methoxy-2-(3-methoxypropoxy)benzene;(2R)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutyl bromide;4-(2-(bromomethyl)-3-methylbutyl)-1-methoxy-2-(3-methoxypropoxy)benzene;1-Methoxy-2-(3-methoxypropoxy)-4-[(3-bromo-(2R)-isopropyl)propyl]benzene;(R)-4-[2-(BroMoMethyl)-3-Methylbutyl]-1-Methoxy-2-(3-Methoxypropoxy)benzene;2-(3-methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene
CBNumber: CB91094179
Molecular Formula: C17H27BrO3
Formula Weight: 359.3
MOL File: 172900-69-5.mol

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2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene Property

Melting point:: 52-53 °C
Boiling point:: 398.8±32.0 °C(Predicted)
Density: 1.173
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Dichloromethane, Ethyl Acetate,
form: Solid
color: White
CAS DataBase Reference: 172900-69-5(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M263140
Product name: 1-Methoxy-2-(3-methoxypropoxy)-4-[(3-bromo-(2R)-isopropyl)propyl]benzene
Packaging: 5g
Price: $400
Updated: 2021/12/16

Matrix Scientific

Product number: 090256
Product name: 2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene
Purity: 95+%
Packaging: 1g
Price: $284
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0029327
Product name: 2-(3-METHOXYPROPOXY)-4-((R)-2-(BROMOMETHYL)-3-METHYLBUTYL)-1-METHOXYBENZENE
Purity: 95.00%
Packaging: 10MG
Price: $704.55
Updated: 2021/12/16

Matrix Scientific

Product number: 090256
Product name: 2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene
Purity: 95+%
Packaging: 5g
Price: $756
Updated: 2021/12/16

Matrix Scientific

Product number: 090256
Product name: 2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene
Purity: 95+%
Packaging: 10g
Price: $1134
Updated: 2021/12/16

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2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

Intermediate in the preparation of Aliskiren.

Synthesis

172900-70-8

172900-69-5

Example 1 Synthesis of (R)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutyl bromide: (R)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutanol (14.82 g, 50 mmol) was dissolved in N,N-dimethylformamide (234 mL), and phosphorus tribromide ( 14.33 g, 50 mmol) and the reaction temperature was controlled at 20 °C. The reaction mixture was stirred at 20 °C for 8 hours. After the reaction was completed, it was cooled to room temperature and the reaction solution was slowly poured into water (702 mL) and extracted three times with hexane. The hexane layers were combined and washed twice each with saturated sodium bicarbonate solution and saturated sodium chloride solution in turn. The organic layer was dried with anhydrous sodium sulfate, filtered and the filtrate was concentrated to give 17 g of oily product. Methanol (51 mL) was added to the oily product and the product was crystallized at a controlled temperature of -10°C. The crystals were collected by filtration. The crystals were collected by filtration and dried under vacuum at room temperature to give 14.3 g of white solid in 79.6% yield, melting point 51-53 °C, chiral purity ≥99.9%.1H NMR (ppm, CDCl3): δ 6.72-6.81 (m, 3H), 4.11 (t, J = 6.4 Hz, 2H), 3.84 (s, 3H), 3.58 (t, J = 6.4 Hz, 2H), 3.42 (dd, J = 4.5, 10.2 Hz, 1H), 3.36 (s, 3H), 3.30 (dd, J = 4.5, 10.2 Hz, 1H), 2.77 (dd, J = 4.8, 13.8 Hz, 1H), 2.48 (dd, J = 4.8, 13.8 Hz, 1H), 2.11 (m, 2H ), 1.86 (m, 1H), 1.60 (m, 1H), 0.99 (m, 6H).

References

[1] Helvetica Chimica Acta, 2003, vol. 86, # 8, p. 2848 - 2870
[2] Tetrahedron Letters, 2005, vol. 46, # 37, p. 6337 - 6340
[3] Patent: US2013/231509, 2013, A1. Location in patent: Paragraph 0021-0022
[4] Patent: WO2011/148392, 2011, A1. Location in patent: Page/Page column 62
[5] Patent: WO2012/78147, 2012, A1. Location in patent: Page/Page column 19-20

2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene Suppliers

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View Lastest Price from 2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene manufacturers

Career Henan Chemical Co

Product: 2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene 172900-69-5
Price: US $7.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-18

172900-69-5, 2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzeneRelated Search:

Anisole p-Anisaldehyde 4-Methoxyphenol Guaiacol 4-Methoxybenzyl cyanide METHOXYTRIMETHYLSILANE (Trifluoromethoxy)benzene POLY(ETHYLENE GLYCOL) METHYL ETHER ACRYLATE 3-Amino-2,2-dimethylpropionamide Aliskiren inter-8 Aliskiren inter-11 1-(((S)-2-(Bromomethyl)-3-methylbutoxy)methyl)benzene 4-Pentenamide, 5-chloro-N,N-dimethyl-2-(1-methylethyl)-, (2S,4E)- Benzene, 4-[(2R)-2-(chloromethyl)-3-methylbutyl]-1-methoxy-2-(3-methoxypropoxy)- 4-Pentenoic acid, 5-chloro-2-(1-methylethyl)-, (2S,4E)- Benzene Aliskiren inter-10 Aliskiren inter-6

(2R)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutyl bromide

2-(3-methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene

Benzene, 4-[(2R)-2-(bromomethyl)-3-methylbutyl]-1-methoxy-2-(3-methoxypropoxy)-

4-[(2R)-2-(Bromomethyl)-3-methylbutyl]-1-methoxy-2-(3-methoxypropoxy)benzene

4-(5-bromo-4-methylpentyl)-1-methoxy-2-(3-methoxypropoxy)benzene

4-(2-(bromomethyl)-3-methylbutyl)-1-methoxy-2-(3-methoxypropoxy)benzene

1-Methoxy-2-(3-methoxypropoxy)-4-[(3-bromo-(2R)-isopropyl)propyl]benzene

2-(3-METHOXYPROPOXY)-4-((4R)-2-(BROMOMETHYL)-3-METHYLBUTYL)-1-METHOXYBENZENE

2-(3-Methoxypropoxy)-4-((R)-2-(broMoMethyl)-3

(R)-4-[2-(BroMoMethyl)-3-Methylbutyl]-1-Methoxy-2-(3-Methoxypropoxy)benzene

-1-methoxybenzene

2-(3-Methoxypropoxy)

2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1...

172900-69-5

C17H27BrO3

Aromatics

Chiral Reagents