L-5-Hydroxytryptophan

ChemicalBook > CAS DataBase List > L-5-Hydroxytryptophan

L-5-Hydroxytryptophan

Product Name: L-5-Hydroxytryptophan
CAS No.: 4350-09-8
Chemical Name: L-5-Hydroxytryptophan
Synonyms: 5-HTP;OXITRIPTAN;(S)-2-Amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid;L-2-AMINO-3-(5-HYDROXYINDOLYL)PROPIONIC ACID;L-5-HTP;Griffonia seed;5-hydroxy-l-tryptopha;5-Hydroxy-L-tryptophane;L-HTP;quietim
CBNumber: CB9110025
Molecular Formula: C11H12N2O3
Formula Weight: 220.22
MOL File: 4350-09-8.mol

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L-5-Hydroxytryptophan Property

Melting point:: 270 °C (dec.) (lit.)
alpha: -32.5 º (c=1,H2O on dry basis)
Boiling point:: 361.16°C (rough estimate)
Density: 0.902 g/mL at 25 °C (lit.)
refractive index: n20/D 1.4850(lit.)
Flash point:: 175 °F
storage temp.: 2-8°C
solubility: H₂O: 10 mg/mL
form: solid
pka: 2.22±0.10(Predicted)
color: white
optical activity: [α]22/D 30°, c = 1 in H2O
Water Solubility: Slightly soluble
Merck: 14,4847
BRN: 88200
LogP: -0.140 (est)
CAS DataBase Reference: 4350-09-8(CAS DataBase Reference)
EPA Substance Registry System: L-5-Hydroxytryptophan (4350-09-8)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-36/37/38-65-20/21/22-20/21
Safety Statements: 36-26
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: YN7110000
F: 3-10
TSCA: Yes
HazardClass: 6.1
PackingGroup: III
HS Code: 29339990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR2597
Product name: 5-Hydroxy-L-tryptophan
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 100MG
Price: $267
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHL80477
Product name: 5-Hydroxy-L-tryptophan
Purity: phyproof? Reference Substance
Packaging: 50MG
Price: $262
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1329913
Product name: 5-Hydroxy-L-tryptophan
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 100mg
Price: $436
Updated: 2024/03/01

Sigma-Aldrich

Product number: 107751
Product name: 5-Hydroxy-L-tryptophan
Purity: 98% (calc. on dried substance)
Packaging: 1g
Price: $44.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: 399698
Product name: 5-Hydroxy-L-tryptophan - CAS 895096 - Calbiochem
Purity: Serotonin precursor.
Packaging: 25G
Price: $466
Updated: 2022/05/15

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L-5-Hydroxytryptophan Chemical Properties,Usage,Production

Chemical Properties

white to pale grey powder

Uses

A labelled metabolite of Tryptophan

Uses

5-Hydroxy-L-Tryptophan is a hydroxylated metabolite of L-Tryptophan

Uses

5-Hydroxy-L-tryptophan has been used:

to inject experimental mice for serotonin detection
as a precursor of 5-hydroxytryptamine and injected in pregnant mice and neonatal rats for vital neutral red staining of lung slices
as a standard in citrate-acetate buffer for its use in high performance liquid chromatography (HPLC) analysis

Definition

ChEBI: 5-hydroxy-L-tryptophan is the L-enantiomer of 5-hydroxytryptophan. It has a role as a human metabolite, a plant metabolite and a mouse metabolite. It is a 5-hydroxytryptophan, a hydroxy-L-tryptophan and a non-proteinogenic L-alpha-amino acid. It is an enantiomer of a 5-hydroxy-D-tryptophan. It is a tautomer of a 5-hydroxy-L-tryptophan zwitterion.

General Description

Colorless to pale pink crystals.

Air & Water Reactions

L-5-Hydroxytryptophan is sensitive to air. Slightly water soluble .

Reactivity Profile

L-5-Hydroxytryptophan reacts with bases. .

Fire Hazard

Flash point data for L-5-Hydroxytryptophan are not available, however, L-5-Hydroxytryptophan is probably combustible.

reaction suitability

reaction type: solution phase peptide synthesis

Trade name

Levothym (Promonta Lundbeck, Germany), Lévotonine (Panpharma, France), Oxyfan (Coli, Italy), Tript-OH (Sigma- Tai, Italy).

Biochem/physiol Actions

Hydroxylation of L-tryptophan occurs in the brain during serotonin synthesis. This is a step that controls the production of serotonin and also yields 5-hydroxy-l-tryptophan (5-HTP) as a metabolite. Thus, consumption 5-HTP, increases the serotonin level, which might result in depression, lack of sleep and severe headache.

Purification Methods

Likely impurities are 5-hydroxy-D-tryptophan and 5-benzyloxytryptophan. Crystallise 5-hydroxy-L-tryptophan under nitrogen from water by adding EtOH. Store it under nitrogen. Also dissolve it in the minimum volume of hot H2O (~0.7g in 4mL) under nitrogen (charcoal) and allowed it to crystallise at 5o. The picrolonate crystallises from H2O with m 184-186o(dec). [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 2732-2737 1961, Morris & Armstrong J Org Chem 22 306 1957, Beilstein 22/14 V 278.]

L-5-Hydroxytryptophan Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from L-5-Hydroxytryptophan manufacturers

Hebei Mujin Biotechnology Co.,Ltd

Product: L-5-Hydroxytryptophan 4350-09-8
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-08-29

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: L-5-Hydroxytryptophan Powder 4350-09-8
Price: US $120.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-05-14

Jinan Jianfeng Chemical Co., Ltd

Product: L-5-Hydroxytryptophan 4350-09-8
Price: US $1.00/ASSAYS
Min. Order: 1g
Purity: 99.99%+
Supply Ability: 20T
Release date: 2021-11-12

4350-09-8, L-5-HydroxytryptophanRelated Search:

5-Hydroxytryptophan L-Tryptophan CHLOROPHOSPHONAZO III Osthole 2-Hydroxy-DL-tryptophan D-5-HYDROXYTRYPTOPHAN O-2-propenyl-Tyrosine (S)-2-Amino-3-(4-ethylphenyl)propanoic acid H-L-Phe(4-CH2OtBu)-OH (2S)-2-amino-3-(4-propoxyphenyl)propanoic acid 2-(Trifluoromethoxy)-L-phenylalanine 2-(1H-indol-3-yl)acetaldehyde 3-[(4-hydroxyphenyl)methyl]piperazine-2,5-dione 2-(3-INDOLYLMETHYL)-L-TRYPTOPHAN N-Acetyl-L-tryptophan 3-(phenylamino)alanine HARMANE-1,2,3,4-TETRAHYDRO-3-CARBOXYLIC ACID Tryptophan Impurity 1（Tryptophan EP Impurity A）

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pretonine

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L-5-HYDROXYTRYPTOPHAN HYDRATE

L-5-HYDROXYTRYPTOPHAN

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5-HTP

C5-HYDROXY-L-TRYPTOPHAN

H-5-HYDROXY-TRP-OH

H-TRP(5-OH)-OH

(S)-2-AMINO-3-(5-HYDROXY-1H-INDOL-3-YL)-PROPIONIC ACID

(2S)-2-Amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid

Levothym

L-5-Hydroxytryptophan,99%

L-5-Hydroxytryptopha

(S)-5-Hydroxytryptophan

5-Hydroxytryptophan(5-HTP,Oxitriptan)

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L-5-Hydroxytryptophan, 99% 5GR

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(S)-2-Amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid

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5-Hydroxy-L-tryptophan(5-HTP)

5-Hydroxy-L-tryptophan99%

L-Trp(5-OH)-OH

OXITRIPTAN

5-Hydroxy-L-tryptophan, Free Acid

Griffonia seed

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l-2-amino-3-[3-(5-hydroxyindole)]propionic acid

5-HYDROXY-1-TRYTOPHAN

5-Hydroxyl-L-tryptophan.

quietim

5-HYDROXY-L-TRYPTOPHAN 99,0 % min

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5-HYDROXY-L-TRYPTOPHAN 99% 5-HTP HPLC

L-2-Amino-3-(5-hydroxyindolyl)propionic acid L-5-HTP 5-HTP

5-Hydroxy-L-tryptophan, Dihydrate

L-HTP

Tryptophan Impurity 9（Tryptophan EP Impurity D）

L-5-Hydroxytryptophan (Synonyms: L-5-HTP

Ghana seed extract

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HPLC>=98%

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