Geclosporin

ChemicalBook > CAS DataBase List > Geclosporin

Product Name: Geclosporin
CAS No.: 74436-00-3
Chemical Name: Geclosporin
Synonyms: CS-2592;Geclosporin;cyclosporin G;Cyclosporine G;Cyclosporin G (9CI);Cyclosporin Impurity G;Cyclosporine Impurity G;Cyclosporine Impurity 7;Ring spore fungus element;Cyclosporin A, 7-L-norvaline-
CBNumber: CB91117216
Molecular Formula: C63H113N11O12
Formula Weight: 1216.64
MOL File: 74436-00-3.mol

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Geclosporin Property

Melting point:: 196-197°
alpha: D20 -245° (c = 1.0 in chloroform); D20 -191° (c = 1.04 in methanol)
Boiling point:: 1297.8±65.0 °C(Predicted)
Density: 1.013±0.06 g/cm3(Predicted)
storage temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: 13.32±0.70(Predicted)
form: Solid
color: White to Off-White
Stability:: Hygroscopic
InChI: InChI=1/C63H113N11O12/c1-25-27-29-41(15)53(76)52-57(80)66-44(28-26-2)59(82)68(18)34-49(75)69(19)45(30-35(3)4)56(79)67-50(39(11)12)62(85)70(20)46(31-36(5)6)55(78)64-42(16)54(77)65-43(17)58(81)71(21)47(32-37(7)8)60(83)72(22)48(33-38(9)10)61(84)73(23)51(40(13)14)63(86)74(52)24/h25,27,35-48,50-53,76H,26,28-34H2,1-24H3,(H,64,78)(H,65,77)(H,66,80)(H,67,79)/b27-25+/t41-,42+,43-,44+,45+,46+,47+,48+,50+,51+,52+,53-/s3
InChIKey: ZMKGDQSIRSGUDJ-LIAWPGETNA-N
SMILES: [C@@]1([H])([C@H](O)[C@H](C)C/C=C/C)C(=O)N[C@@H](CCC)C(=O)N(C)CC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)N1C |&1:0,2,4,13,26,34,42,50,55,61,70,79,r|

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: C990143
Product name: CyclosporinG
Packaging: 5mg
Price: $570
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0011154
Product name: CYCLOSPORIN G
Purity: 95.00%
Packaging: 5MG
Price: $501.6
Updated: 2021/12/16

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Geclosporin Chemical Properties,Usage,Production

Uses

Cylclosporin G is a derivative of Cyclosporin A, an immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. A group of nonpolar cyclic oligopeptides with immunosupppressant activity.

Uses

Cylclosporin G is a derivative of Cyclosporin A (C989900), an immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. A group of nonpolar cyclic oligopeptides with immunosupppressant activity.

Geclosporin Preparation Products And Raw materials

Raw materials

Preparation Products

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74436-00-3, GeclosporinRelated Search:

Cyclosporin B Cyclosporin H CYCLOSPORIN D (3R,4R)-3-Hydroxy-5-[(E)-1-propenyl]cyclo[L-Leu-L-Abu-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-] Cyclosporin C CYCLOSPORIN J 1,1,4,7,10,10-HEXAMETHYLTRIETHYLENETETRAMINE Cyclosporine Cyclosporin A Geclosporin

Cyclosporine Impurity G

Cyclosporin Impurity G

CS-2592

Cyclosporine G/Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-dimethyl-L-2-aminooctanoyl-L-norvalyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl]

Cyclosporine G

Geclosporin

(3R,4R)-3-Hydroxy-N-methyl-5-[(E)-1-propenyl]-cyclo(L-Leu-L-Nva-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-)

Cyclo(((2S,3R,4R,6E)-3-hydroxy-4-methyl-2-(methylamino)-6-octenoyl)-L-norvalyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl)

Cyclosporin A, 7-L-norvaline-

cyclosporin G

Ring spore fungus element

Cyclosporin Impurity 7(Cyclosporin G)

(3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-33-((1R,2R,E)-1-hydroxy-2-methylhex-4-en-1-yl)-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-30-propyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone

Cyclosporine Impurity 7

Cyclosporin G (9CI)

(3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-33-[(1R,2R,4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-bis(propan-2-yl)-30-propyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecone

74436-00-3

C63H113N11O12