CYCLOSPORIN D
- Product Name
- CYCLOSPORIN D
- CAS No.
- 63775-96-2
- Chemical Name
- CYCLOSPORIN D
- Synonyms
- CS-1740;Ring spore D;CYCLOSPORIN D;Val2-cyclosporine;Cyclosporin D, >=95%;Cyclosporin D solution;cyclosporin impurity D;7-L-Valinecyclosporin A;Cyclosporine IMpurity-D;Cyclosporine Impurity 4
- CBNumber
- CB6276179
- Molecular Formula
- C63H113N11O12
- Formula Weight
- 1216.64
- MOL File
- 63775-96-2.mol
CYCLOSPORIN D Property
- Melting point:
- 148-1510C
- alpha
- D20 -245° (c = 0.52 in CHCl3); D20 -211° (c = 0.51 in methanol)
- Boiling point:
- 1294.7±65.0 °C(Predicted)
- Density
- 1.015±0.06 g/cm3(Predicted)
- Flash point:
- 9 °C
- storage temp.
- -20°C Freezer
- solubility
- Chloroform (Sparingly), Ethyl Aceatate (Slightly), Methanol (Slightly)
- form
- Colorless to off-white crystalline solid.
- pka
- 13.22±0.70(Predicted)
- color
- White to Off-White
- InChIKey
- YJDYDFNKCBANTM-QCWCSKBGSA-N
Safety
- Hazard Codes
- F,Xn,T
- Risk Statements
- 11-20/21/22-36-39/23/24/25-23/24/25
- Safety Statements
- 16-36/37-45-7
- RIDADR
- UN 1648 3 / PGII
- WGK Germany
- 2
- HS Code
- 29419090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C-108
- Product name
- Cyclosporin D solution
- Purity
- 1.0?mg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant?
- Packaging
- 1mL
- Price
- $288
- Updated
- 2024/03/01
- Product number
- 15477
- Product name
- Cyclosporin D
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $106
- Updated
- 2024/03/01
- Product number
- 15477
- Product name
- Cyclosporin D
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $239
- Updated
- 2024/03/01
- Product number
- C988910
- Product name
- CyclosporinD
- Packaging
- 50mg
- Price
- $870
- Updated
- 2021/12/16
- Product number
- FC20756
- Product name
- Cyclosporin D
- Packaging
- 25mg
- Price
- $412.5
- Updated
- 2021/12/16
CYCLOSPORIN D Chemical Properties,Usage,Production
Chemical Properties
Colorless Crystalline Solid
Uses
A group of nonpolar cyclic oligopeptides with immunosupppressant activity.
Uses
Cyclosporin D is a minor analogue of the cyclosporin family which is only weakly immunologically active. Cyclosporin D is a potent inhibitor of tumour-promoting phorbol esters on mouse skin in vivo, and a potent inhibitor of calcium/calmodulin-dependent EF-2 phosphorylation in vitro.
Biological Activity
cyclosporin d is an immunosuppressive agent [1].cyclosporin d (csd) is an analogue of cyclosporine a with weak immunosuppressive activity. cyclosporin d has been used as an internal standard for the quantification of cyclosporin a. in human multidrug-resistant ovarian cancer cells, cyclosporin d significantly overcame adriamycin resistance [2]. in lymphocyte, csd weakly inhibited pha-, pwm-, and pma + ca2+-induced cell proliferation [3].in mice, csd inhibited edema in mouse ear and alkaline phosphatase activity in mouse skin induced by tpa by 98% and 88%, respectively. in cytosol of mouse pancreas, csd inhibited the ca2+/calmodulin-dependent phosphorylation of the elongation factor 2 (ef-2) and the tpa-induced increase of ef-2 [1]. cyclosporin d was effective in inhibiting p. falciparum parasite in vitro and p. berghei malaria parasite development in vivo when administered orally [4].
storage
+4°C
References
[1]. gschwendt m, kittstein w, marks f. the weak immunosuppressant cyclosporine d as well as the immunologically inactive cyclosporine h are potent inhibitors in vivo of phorbol ester tpa-induced biological effects in mouse skin and of ca2+/calmodulin dependent ef-2 phosphorylation in vitro. biochem biophys res commun, 1988, 150(2): 545-551.
[2]. mizuno k, furuhashi y, misawa t, et al. modulation of multidrug resistance by immunosuppressive agents: cyclosporin analogues, fk506 and mizoribine. anticancer res, 1992, 12(1): 21-25.
[3]. sadeg n, pham-huy c, rucay p, et al. in vitro and in vivo comparative studies on immunosuppressive properties of cyclosporines a, c, d and metabolites m1, m17 and m21. immunopharmacol immunotoxicol, 1993, 15(2-3): 163-177.
[4]. uadia po1, ezeamuzie ic, ladan mj, et al. antimalarial activity of cyclosporins a, c and d. afr j med med sci, 1994, 23(1): 47-51.
CYCLOSPORIN D Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from CYCLOSPORIN D manufacturers
- Product
- Val2-Cyclosporine 63775-96-2
- Price
- US $128.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1 ton
- Release date
- 2021-12-15
- Product
- Val2-Cyclosporine
- Price
- US $3.21/Kg/Bag
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20tons
- Release date
- 2021-12-30
- Product
- CYCLOSPORIN D 63775-96-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-02