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CYCLOSPORIN D

Product Name
CYCLOSPORIN D
CAS No.
63775-96-2
Chemical Name
CYCLOSPORIN D
Synonyms
CS-1740;Ring spore D;CYCLOSPORIN D;Val2-cyclosporine;Cyclosporin D, >=95%;Cyclosporin D solution;cyclosporin impurity D;7-L-Valinecyclosporin A;Cyclosporine IMpurity-D;Cyclosporine Impurity 4
CBNumber
CB6276179
Molecular Formula
C63H113N11O12
Formula Weight
1216.64
MOL File
63775-96-2.mol
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CYCLOSPORIN D Property

Melting point:
148-1510C
alpha 
D20 -245° (c = 0.52 in CHCl3); D20 -211° (c = 0.51 in methanol)
Boiling point:
1294.7±65.0 °C(Predicted)
Density 
1.015±0.06 g/cm3(Predicted)
Flash point:
9 °C
storage temp. 
-20°C Freezer
solubility 
Chloroform (Sparingly), Ethyl Aceatate (Slightly), Methanol (Slightly)
form 
Colorless to off-white crystalline solid.
pka
13.22±0.70(Predicted)
color 
White to Off-White
InChIKey
YJDYDFNKCBANTM-QCWCSKBGSA-N
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Safety

Hazard Codes 
F,Xn,T
Risk Statements 
11-20/21/22-36-39/23/24/25-23/24/25
Safety Statements 
16-36/37-45-7
RIDADR 
UN 1648 3 / PGII
WGK Germany 
2
HS Code 
29419090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C-108
Product name
Cyclosporin D solution
Purity
1.0?mg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant?
Packaging
1mL
Price
$288
Updated
2024/03/01
Cayman Chemical
Product number
15477
Product name
Cyclosporin D
Purity
≥95%
Packaging
1mg
Price
$106
Updated
2024/03/01
Cayman Chemical
Product number
15477
Product name
Cyclosporin D
Purity
≥95%
Packaging
5mg
Price
$239
Updated
2024/03/01
TRC
Product number
C988910
Product name
CyclosporinD
Packaging
50mg
Price
$870
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC20756
Product name
Cyclosporin D
Packaging
1mg
Price
$55
Updated
2021/12/16
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CYCLOSPORIN D Chemical Properties,Usage,Production

Chemical Properties

Colorless Crystalline Solid

Uses

A group of nonpolar cyclic oligopeptides with immunosupppressant activity.

Uses

Cyclosporin D is a minor analogue of the cyclosporin family which is only weakly immunologically active. Cyclosporin D is a potent inhibitor of tumour-promoting phorbol esters on mouse skin in vivo, and a potent inhibitor of calcium/calmodulin-dependent EF-2 phosphorylation in vitro.

Biological Activity

cyclosporin d is an immunosuppressive agent [1].cyclosporin d (csd) is an analogue of cyclosporine a with weak immunosuppressive activity. cyclosporin d has been used as an internal standard for the quantification of cyclosporin a. in human multidrug-resistant ovarian cancer cells, cyclosporin d significantly overcame adriamycin resistance [2]. in lymphocyte, csd weakly inhibited pha-, pwm-, and pma + ca2+-induced cell proliferation [3].in mice, csd inhibited edema in mouse ear and alkaline phosphatase activity in mouse skin induced by tpa by 98% and 88%, respectively. in cytosol of mouse pancreas, csd inhibited the ca2+/calmodulin-dependent phosphorylation of the elongation factor 2 (ef-2) and the tpa-induced increase of ef-2 [1]. cyclosporin d was effective in inhibiting p. falciparum parasite in vitro and p. berghei malaria parasite development in vivo when administered orally [4].

storage

+4°C

References

[1]. gschwendt m, kittstein w, marks f. the weak immunosuppressant cyclosporine d as well as the immunologically inactive cyclosporine h are potent inhibitors in vivo of phorbol ester tpa-induced biological effects in mouse skin and of ca2+/calmodulin dependent ef-2 phosphorylation in vitro. biochem biophys res commun, 1988, 150(2): 545-551.
[2]. mizuno k, furuhashi y, misawa t, et al. modulation of multidrug resistance by immunosuppressive agents: cyclosporin analogues, fk506 and mizoribine. anticancer res, 1992, 12(1): 21-25.
[3]. sadeg n, pham-huy c, rucay p, et al. in vitro and in vivo comparative studies on immunosuppressive properties of cyclosporines a, c, d and metabolites m1, m17 and m21. immunopharmacol immunotoxicol, 1993, 15(2-3): 163-177.
[4]. uadia po1, ezeamuzie ic, ladan mj, et al. antimalarial activity of cyclosporins a, c and d. afr j med med sci, 1994, 23(1): 47-51.

CYCLOSPORIN D Preparation Products And Raw materials

Raw materials

Preparation Products

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CYCLOSPORIN D Suppliers

Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696,15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4456
Advantage
55
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Fujian Kerui Pharmaceutical Co., Ltd.
Tel
+86-591-83309157; 18505919179
Fax
0591-83309157
Email
23115188@qq.com
Country
China
ProdList
18
Advantage
62
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
9387
Advantage
52
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
meilunui@163.com
Country
China
ProdList
4727
Advantage
58
T&W GROUP
Tel
021-61551611 13296011611
Fax
+86 21-50676805
Email
contact@trustwe.com
Country
China
ProdList
9895
Advantage
58
Chengdu Climax Biotech Co., Ltd.
Tel
028-83311324 1278112614
Fax
028-83311324
Email
climaxbiotech@gmail.com
Country
China
ProdList
925
Advantage
58
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View Lastest Price from CYCLOSPORIN D manufacturers

Hong Kong Tiansheng New Material Trading Co., Ltd
Product
Val2-Cyclosporine 63775-96-2
Price
US $128.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1 ton
Release date
2021-12-15
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
Val2-Cyclosporine
Price
US $3.21/Kg/Bag
Min. Order
1KG
Purity
99%
Supply Ability
20tons
Release date
2021-12-30
Career Henan Chemical Co
Product
CYCLOSPORIN D 63775-96-2
Price
US $1.00/KG
Min. Order
1KG
Purity
95-99%
Supply Ability
1ton
Release date
2020-01-02

63775-96-2, CYCLOSPORIN DRelated Search:


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