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CYCLOSPORIN D

Product Name
CYCLOSPORIN D
CAS No.
63775-96-2
Chemical Name
CYCLOSPORIN D
Synonyms
CS-1740;Ring spore D;CYCLOSPORIN D;Val2-cyclosporine;Cyclosporin D, >=95%;Cyclosporin D solution;cyclosporin impurity D;7-L-Valinecyclosporin A;Cyclosporine IMpurity-D;Cyclosporine Impurity 4
CBNumber
CB6276179
Molecular Formula
C63H113N11O12
Formula Weight
1216.64
MOL File
63775-96-2.mol
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CYCLOSPORIN D Property

Melting point:
148-1510C
alpha 
D20 -245° (c = 0.52 in CHCl3); D20 -211° (c = 0.51 in methanol)
Boiling point:
1294.7±65.0 °C(Predicted)
Density 
1.015±0.06 g/cm3(Predicted)
Flash point:
9 °C
storage temp. 
-20°C Freezer
solubility 
Chloroform (Sparingly), Ethyl Aceatate (Slightly), Methanol (Slightly)
form 
Colorless to off-white crystalline solid.
pka
13.22±0.70(Predicted)
color 
White to Off-White
InChIKey
YJDYDFNKCBANTM-QCWCSKBGSA-N
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Safety

Hazard Codes 
F,Xn,T
Risk Statements 
11-20/21/22-36-39/23/24/25-23/24/25
Safety Statements 
16-36/37-45-7
RIDADR 
UN 1648 3 / PGII
WGK Germany 
2
HS Code 
29419090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C-108
Product name
Cyclosporin D solution
Purity
1.0?mg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant?
Packaging
1mL
Price
$288
Updated
2024/03/01
Cayman Chemical
Product number
15477
Product name
Cyclosporin D
Purity
≥95%
Packaging
1mg
Price
$106
Updated
2024/03/01
Cayman Chemical
Product number
15477
Product name
Cyclosporin D
Purity
≥95%
Packaging
5mg
Price
$239
Updated
2024/03/01
TRC
Product number
C988910
Product name
CyclosporinD
Packaging
50mg
Price
$870
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC20756
Product name
Cyclosporin D
Packaging
25mg
Price
$412.5
Updated
2021/12/16
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CYCLOSPORIN D Chemical Properties,Usage,Production

Chemical Properties

Colorless Crystalline Solid

Uses

A group of nonpolar cyclic oligopeptides with immunosupppressant activity.

Uses

Cyclosporin D is a minor analogue of the cyclosporin family which is only weakly immunologically active. Cyclosporin D is a potent inhibitor of tumour-promoting phorbol esters on mouse skin in vivo, and a potent inhibitor of calcium/calmodulin-dependent EF-2 phosphorylation in vitro.

Biological Activity

cyclosporin d is an immunosuppressive agent [1].cyclosporin d (csd) is an analogue of cyclosporine a with weak immunosuppressive activity. cyclosporin d has been used as an internal standard for the quantification of cyclosporin a. in human multidrug-resistant ovarian cancer cells, cyclosporin d significantly overcame adriamycin resistance [2]. in lymphocyte, csd weakly inhibited pha-, pwm-, and pma + ca2+-induced cell proliferation [3].in mice, csd inhibited edema in mouse ear and alkaline phosphatase activity in mouse skin induced by tpa by 98% and 88%, respectively. in cytosol of mouse pancreas, csd inhibited the ca2+/calmodulin-dependent phosphorylation of the elongation factor 2 (ef-2) and the tpa-induced increase of ef-2 [1]. cyclosporin d was effective in inhibiting p. falciparum parasite in vitro and p. berghei malaria parasite development in vivo when administered orally [4].

storage

+4°C

References

[1]. gschwendt m, kittstein w, marks f. the weak immunosuppressant cyclosporine d as well as the immunologically inactive cyclosporine h are potent inhibitors in vivo of phorbol ester tpa-induced biological effects in mouse skin and of ca2+/calmodulin dependent ef-2 phosphorylation in vitro. biochem biophys res commun, 1988, 150(2): 545-551.
[2]. mizuno k, furuhashi y, misawa t, et al. modulation of multidrug resistance by immunosuppressive agents: cyclosporin analogues, fk506 and mizoribine. anticancer res, 1992, 12(1): 21-25.
[3]. sadeg n, pham-huy c, rucay p, et al. in vitro and in vivo comparative studies on immunosuppressive properties of cyclosporines a, c, d and metabolites m1, m17 and m21. immunopharmacol immunotoxicol, 1993, 15(2-3): 163-177.
[4]. uadia po1, ezeamuzie ic, ladan mj, et al. antimalarial activity of cyclosporins a, c and d. afr j med med sci, 1994, 23(1): 47-51.

CYCLOSPORIN D Preparation Products And Raw materials

Raw materials

Preparation Products

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CYCLOSPORIN D Suppliers

Canada 1 China 181 Germany 1 India 5 United Kingdom 6 United States 26 Global 220
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View Lastest Price from CYCLOSPORIN D manufacturers

Moxin Chemicals
Product
Ciclosporin EP Impurity G 63775-96-2
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
95%+
Supply Ability
100000
Release date
2025-01-17
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
Val2-Cyclosporine 63775-96-2
Price
US $128.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1 ton
Release date
2021-12-15
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
Val2-Cyclosporine
Price
US $3.21/Kg/Bag
Min. Order
1KG
Purity
99%
Supply Ability
20tons
Release date
2021-12-30

63775-96-2, CYCLOSPORIN DRelated Search:

CYCLOSPORIN C CYCLOSPORIN H Cyclosporin A cyclosporin G 1,1,4,7,10,10-HEXAMETHYLTRIETHYLENETETRAMINE CYCLOSPORIN D CYCLOSPORIN B CYCLOSPORINE Cyclosporin A-d4 CYCLOSPORIN J (melle-4)cyclosporin Cyclosporin D-d4 6-[(2S,3R,4R,6E)-3,8-Dihydroxy-4-methyl-2-(methylamino)-6-octenoic acid]-cyclosporin A,Cyclosporin A Metabolite 17,Cyclosporin AM 1,Cyclosporin Metabolite 17 Cyclosporin A-13C2,d4 cyclosporin lactam(3,4) [D-Lys8]cyclosporin A,D-Lysin8 cyclosporin A cyclosporin O cyclosporin A, MeAla(3)-Phe(7)-Ser(8)-

  • CYCLOSPORIN D
  • (3R,4R)-3-Hydroxy-N-methyl-5-[(E)-1-propenyl]-cyclo(L-Leu-L-Val-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-)
  • (3R,4R)-3-Hydroxy-N-methyl-5-[(E)-1-propenyl]cyclo(L-Leu-L-Val-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-)
  • Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-valyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl]
  • Val2-cyclosporine
  • 7-L-Valinecyclosporin A
  • Cyclosporin D, froM MicroMonospora
  • Cyclosporine IMpurity-D
  • 7-L-valinecyclosporine A
  • 1-(3-Chlorophenyl)piperazine-D8 hydrochloride solution
  • Cyclosporin D solution
  • Cyclosporin D, >=95%
  • Cyclosporin D, 95%, from Micromonospora
  • Cyclosporin Impurity 4(Cyclosporin D)
  • Cyclosporine EP Impurity D
  • Cyclosporine D/Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-valyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl]
  • CS-1740
  • Cyclosporin DCyclosporine
  • Cyclosporin A, 7-L-valine-
  • Cyclosporine Impurity 4
  • Cyclosporin DQ: What is Cyclosporin D Q: What is the CAS Number of Cyclosporin D Q: What is the storage condition of Cyclosporin D Q: What are the applications of Cyclosporin D
  • Ring spore D
  • cyclosporin impurity D
  • Cyclosporin Impurity 4(Cyclosporin D)(Ciclosporin EP Impurity G)
  • Cyclosporin D (Ciclosporin EP Impurity G)
  • Cyclosporin D, EvoPure?
  • (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-33-((1R,2R,E)-1-Hydroxy-2-methylhex-4-en-1-yl)-6,9,18,24-tetraisobutyl-3,21,30-triisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone
  • (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-33-[(1R,2R,4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21,30-tris(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecone
  • Ciclosporin EP Impurity G (Cyclosporin D)
  • Ciclosporin EP Impurity G
  • 63775-96-2
  • C63H111N11O12
  • Anti-cancer&immunity
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