Butedronic acid Property

Melting point:

149.5 °C

Boiling point:

701.4±70.0 °C(Predicted)

Density 

2.095±0.06 g/cm3(Predicted)

pka

0.38±0.10(Predicted)

Safety

Hazard Codes 

C

Risk Statements 

34-43

Safety Statements 

26-36/37/39-45

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

H317May cause an allergic skin reaction

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

Butedronic acid Chemical Properties,Usage,Production

Originator

Butedronic acid,Bayer A.G.

Definition

ChEBI: Butedronic acid is a 1,1-bis(phosphonic acid).

Manufacturing Process

0.5 mole of methylene diphosphonic acid tetraethyl ester is heated for 6 h to 110°C with 0.5 mole of maleic acid diethyl ester in the presence of 25 ml of a saturated sodium ethylate solution. The sodium ethylate is then neutralized with acetic acid and the reaction mixture is quickly distilled invacuo in order to avoid decomposition. The crude distillate is redistillated, the main fraction accumulating in the range from 190-213°C at a pressure of 0.05 Torr, yield 50%.
The ester is hydrolyzed by boiling with concentrated hydrochloric acid. 1,1- Diphosphonopropane-2,3-dicarboxylic acid crystallizes out after purification with active carbon and concentration of the hydrolysis product, yield 100%.

Therapeutic Function

Diagnostic aid