ChemicalBook > CAS DataBase List > 4-Amino-2-trifluoromethylpyridine
4-Amino-2-trifluoromethylpyridine
- Product Name
- 4-Amino-2-trifluoromethylpyridine
- CAS No.
- 147149-98-2
- Chemical Name
- 4-Amino-2-trifluoromethylpyridine
- Synonyms
- 2-(Trifluoromethyl)pyridin-4-amine;Enasidenib Intermediate 4;2-trifluoromethyl-4-aminopyridine;2-(trifluoromethyl)pyridin-4-amin;2-Ctrifluoromethyl/pyridin-4-amine;2-(Trifluoromethyl)-4-pyridinamine;2-Trifluoromethyl-pyridin-4-ylamine;4-Pyridinamine, 2-(trifluoromethyl)-;4-Amino-2-(trifluoromethyl)-pyridine;2-CTRIFLUOROMETHYL/PYRIDIN-4-AMINE,98%
- CBNumber
- CB91120902
- Molecular Formula
- C6H5F3N2
- Formula Weight
- 162.11
- MOL File
- 147149-98-2.mol
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4-Amino-2-trifluoromethylpyridine Property
- Melting point:
- 58-62°C
- Boiling point:
- 230.7±40.0 °C(Predicted)
- Density
- 1.368±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- powder to crystal
- pka
- 4.62±0.50(Predicted)
- color
- White to Almost white
- InChI
- InChI=1S/C6H5F3N2/c7-6(8,9)5-3-4(10)1-2-11-5/h1-3H,(H2,10,11)
- InChIKey
- LYNBZRJTRHTSKI-UHFFFAOYSA-N
- SMILES
- C1(C(F)(F)F)=NC=CC(N)=C1
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 765880
- Product name
- 4-Amino-2-(trifluoromethyl)pyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $81.8
- Updated
- 2025/07/31
TCI Chemical
- Product number
- A2861
- Product name
- 4-Amino-2-(trifluoromethyl)pyridine
- Packaging
- 1G
- Price
- $62
- Updated
- 2025/07/31
TRC
- Product number
- A633440
- Product name
- 4-Amino-2-(trifluoromethyl)pyridine
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- HCH0316526
- Product name
- 4-AMINO-2-(TRIFLUOROMETHYL)PYRIDINE
- Purity
- 97.00%
- Packaging
- 25G
- Price
- $2390.85
- Updated
- 2021/12/16
AK Scientific
- Product number
- W3211
- Product name
- 4-Amino-2-(trifluoromethyl)pyridine
- Packaging
- 10g
- Price
- $252
- Updated
- 2021/12/16
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4-Amino-2-trifluoromethylpyridine Chemical Properties,Usage,Production
Chemical Properties
4-Amino-2-trifluoromethylpyridine can undergo a Chichibabin reaction to introduce an additional amine group in the para-position. It is employed in the synthesis of oral checkpoint kinase inhibitor for immunotherapy.
Uses
4-Amino-2-(trifluoromethyl)pyridine are involved in many syntheses of active pharmaceutical ingredients (APIs), such as naporafenib, a RAF inhibitor used in the treatment of RAF-driven cancers.
Synthesis
147149-97-1
147149-98-2
The general procedure for the synthesis of 2-trifluoromethyl-4-aminopyridine from the compound (CAS:147149-97-1) is as follows: 3) 0.86 g of the compound of Example 65.4 was dissolved in 50 mL of anhydrous ethanol at room temperature, and 88 mg of 10% palladium/carbon catalyst was added under argon protection. Subsequently, the reaction was hydrogenated for 3 hours at room temperature and 5 bar hydrogen pressure. Upon completion of the reaction, the reaction mixture was filtered through a depth filter and washed with ethanol. The filtrate was concentrated under reduced pressure and the residue was purified by silica gel column chromatography with the eluent being a 95:5 solvent mixture of dichloromethane/methanol. Compound 65.5 was finally obtained in 88% yield.1H NMR (δ, ppm): 8.10 (d, 1H), 6.9 (s, 1H), 6.65 (d, 1H), 6.52 (s, 2H).
References
[1] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 20, p. 7150 - 7163
[2] Patent: US2009/215728, 2009, A1. Location in patent: Page/Page column 56
[3] Patent: WO2010/126851, 2010, A1. Location in patent: Page/Page column 114
[4] Patent: WO2007/119055, 2007, A1. Location in patent: Page/Page column 34-35
4-Amino-2-trifluoromethylpyridine Preparation Products And Raw materials
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View Lastest Price from 4-Amino-2-trifluoromethylpyridine manufacturers
Shaanxi Dideu New Materials Co. Ltd
- Product
- 4-Amino-2-trifluoromethylpyridine 147149-98-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-12
Shaanxi Dideu Medichem Co. Ltd
- Product
- 4-Amino-2-trifluoromethylpyridine 147149-98-2
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-07
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- 4-Amino-2-trifluoromethylpyridine 147149-98-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
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