3'-DEPHOSPHOCOENZYME A
- Product Name
- 3'-DEPHOSPHOCOENZYME A
- CAS No.
- 3633-59-8
- Chemical Name
- 3'-DEPHOSPHOCOENZYME A
- Synonyms
- Dephospho-CoA;3'-dephospho-CoA;dephosphocoenzyme A;3'-DEPHOSPHOCOENZYME A;3'-Dephosphocoenzyme A;3'-O-dephosphono-coenzyme A;Coenzyme A, 3'-O-dephosphono-;3'-DEPHOSPHOCOENZYME A FREE ACID;3'-Dephosphocoenzyme A >=90% (HPLC);[5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-[hydroxy-[3-hydroxy-2,2-dimethyl-3-[2-(2-sulfanylethylcarbamoyl)ethylcarbamoyl]propoxy]-phosphoryl]oxy-phosphinic acid
- CBNumber
- CB9115282
- Molecular Formula
- C21H35N7O13P2S
- Formula Weight
- 687.55
- MOL File
- 3633-59-8.mol
3'-DEPHOSPHOCOENZYME A Property
- Density
- 1.85±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Water: 50 mg/ml
- form
- A crystalline solid
- pka
- 1.16±0.50(Predicted)
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- D3385
- Product name
- 3′-Dephosphocoenzyme A
- Purity
- ≥90% (HPLC)
- Packaging
- 5mg
- Price
- $218
- Updated
- 2024/03/01
- Product number
- D3385
- Product name
- 3′-Dephosphocoenzyme A
- Purity
- ≥90% (HPLC)
- Packaging
- 25mg
- Price
- $782
- Updated
- 2024/03/01
- Product number
- 27390
- Product name
- 3''-Dephosphocoenzyme A
- Packaging
- 1mg
- Price
- $60
- Updated
- 2024/03/01
- Product number
- 27390
- Product name
- 3''-Dephosphocoenzyme A
- Packaging
- 10mg
- Price
- $351
- Updated
- 2024/03/01
- Product number
- 27390
- Product name
- 3''-Dephosphocoenzyme A
- Packaging
- 5mg
- Price
- $190
- Updated
- 2024/03/01
3'-DEPHOSPHOCOENZYME A Chemical Properties,Usage,Production
Description
3''-Dephosphocoenzyme A is an intermediate in the biosynthesis of coenzyme A (CoA; Item Nos. 16147 | 21499 | 21722) from pantothenic acid (vitamin B5; ). It is phosphorylated by CoA synthase in humans to form CoA. 3''-Dephosphocoenzyme A can be used as a transcription initiator in the synthesis of CoA-RNA by in vitro transcription.
Uses
Dephosphocoenzyme A is the direct precursor of coenzyme A. It is used for the synthesis of coenzyme A by bifunctional CoA Synthase (CoASy, 4′-phosphopantetheine adenylyltransferase/dephospho-CoA kinase) which performs the transfer of the γ-phosphate of ATP to dephosphocoenzyme A.
Definition
ChEBI: An adenosine 5'-phosphate that is coenzyme A in which the phosphate group at position 3' has been replaced by a hydrogen atom. It is an intermediate metabolite in pantothenate and CoA biosynthesis
Biochem/physiol Actions
3′-Dephosphocoenzyme A (DepCoA), also called desphosphoCoA (dpCoA), is synthesized from 4-phosphopantetheine by the enzyme phosphopanthetheine adenylyltransferase. It is an intermediate in coenzyme A biosynthetic pathway. In the presence of dephospho-CoA kinase (CoaE), dephosphocoenzyme A is converted to coenzyme A. 3′-Dephosphocoenzyme shares adenosine-diphosphate substructure as like the purines and is a non-canonical nucleotide and is an initiator of transcription initiation. It is routinely used in in vitro transcription studies to initiate RNA synthesis.