ChemicalBook > CAS DataBase List > ANP 1-28, HUMAN

ANP 1-28, HUMAN

Product Name: ANP 1-28, HUMAN
CAS No.: 89213-87-6
Chemical Name: ANP 1-28, HUMAN
Synonyms: Carperitide;ATRIAL NATRIURETIC PEPTIDE HUMAN;SLRRSSCFGGRMDRIGAQSGLGCNSFRY;ATRIAL NATRIURETIC FACTOR (1-28) (HUMAN, PORCINE);HANF;α-hANP;carperitida;ANP HUMAN, 1-28;ANP 1-28, HUMAN;ANF 1-28, HUMAN
CBNumber: CB9116087
Molecular Formula: C127H203N45O39S3
Formula Weight: 3080.44
MOL File: 89213-87-6.mol

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ANP 1-28, HUMAN Property

Density: 1.55±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Water: 1 mg/ml
form: A lyophilized powder
Sequence: H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH，(Disulfide bridge: Cys-Cys)
InChIKey: NSQLIUXCMFBZME-VUEHYBQXNA-N

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 24539
Product name: Atrial Natriuretic Peptide (1-28) (human) (trifluoroacetate salt)
Purity: ≥95%
Packaging: 1mg
Price: $384
Updated: 2024/03/01

Tocris

Product number: 1906
Product name: AtrialNatriureticFactor(1-28)(human,porcine)
Packaging: 1
Price: $367
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA110233
Product name: Atrial Natriuretic Factor (1-28) (human) hydrochloride salt H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH hydrochloride salt (Disulfide bond)
Packaging: 500ug
Price: $100
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA110233
Product name: Atrial Natriuretic Factor (1-28) (human) hydrochloride salt H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH hydrochloride salt (Disulfide bond)
Packaging: 5mg
Price: $602
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA110233
Product name: Atrial Natriuretic Factor (1-28) (human) hydrochloride salt H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH hydrochloride salt (Disulfide bond)
Packaging: 10mg
Price: $1047
Updated: 2021/12/16

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ANP 1-28, HUMAN Chemical Properties,Usage,Production

Description

Carperitide is the α-human atrial natriuretic peptide (α-hANP) produced by recombinant technology. It was introduced in Japan as a treatment for acute congestive heart failure (CHF). In dogs with CHF, carperitide significantly reduced the elevated left ventricular end-diastolic pressure and the index of myocardial oxygen consumption (systolic blood pressure x heart rate). In a clinical trial, carperitide was effective in improving hemodynamics and symptoms in 60% of patients with acute CHF. Carperitide was reported to be well tolerated with no significant adverse effects clinically. A beneficial effect on hemodynamics has been reported in chronic heart failure patients. Carperitide is also in clinical trials for maintenance of blood pressure during surgical operations.

Description

Atrial natriuretic peptide (ANP) is an endogenous peptide generated by proteolysis of prepro-ANP that is secreted by cardiomyocytes in the heart. It has effects on the renal and cardiovascular systems that decrease vasoconstriction, inhibit renin secretion, and increase sodium excretion. Human ANP binds to ANP receptors on cultured vascular smooth muscle cells (VSMCs) with a K_d value of approximately 1-2 nM and increases cGMP levels in a dose-dependent manner. It relaxes potassium-induced contraction of isolated canine renal arterial strips when used at concentrations of 10 and 100 ng/ml and dilates renal arteries in anesthetized dogs when used at doses ranging from 10 to 100 ng/kg. In a rat model of heart failure following experimental autoimmune myocarditis, human ANP, via osmotic mini pump for 28 days, decreases cardiomyocyte size as well as the amount of cardiac fibrosis and left ventricular remodeling. ANP (1-28) (human) is a 28 amino acid peptide corresponding to the human protein sequence.

Originator

Suntory (Japan)

Uses

Treatment of decompensated congestive heart failure.

Definition

ChEBI: Carperitide is a polypeptide.

brand name

Daiichi Suntory, Japan.

References

[1] T.GEOFFREY FLYNN Adolfo J de B Mercedes L de Bold. The amino acid sequence of an atrial peptide with potent diuretic and natriuretic properties[J]. Biochemical and biophysical research communications, 1983, 117 3: Pages 859-865. DOI: 10.1016/0006-291x(83)91675-3
[2] MAACK T. Role of atrial natriuretic factor in volume control[J]. Kidney international, 1996, 49 6: Pages 1732-1737. DOI: 10.1038/ki.1996.257
[3] YUKIO HIRATA. Specific receptors for atrial natriuretic factor (ANF) in cultured vascular smooth muscle cells of rat aorta[J]. Biochemical and biophysical research communications, 1984, 125 2: Pages 562-568. DOI: 10.1016/0006-291x(84)90576-x
[4] T. ISHIHARA. Vasodilatory and diuretic actions of α-human atrial natriuretic polypeptide (α-hANP)[J]. Life sciences, 1985, 36 12: Pages 1205-1215. DOI: 10.1016/0024-3205(85)90239-5
[5] KOMEI TANAKA. Long-term carperitide treatment attenuates left ventricular remodeling in rats with heart failure after autoimmune myocarditis.[J]. Journal of Cardiovascular Pharmacology, 2009: 232-239. DOI: 10.1097/fjc.0b013e3181b0cf50

ANP 1-28, HUMAN Preparation Products And Raw materials

Raw materials

Preparation Products

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ANP 1-28, HUMAN Suppliers

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View Lastest Price from ANP 1-28, HUMAN manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Carperitide 89213-87-6
Price: US $0.00/g
Min. Order: 1g
Purity: 98%min
Supply Ability: 1000g
Release date: 2023-01-12

Henan Aochuang Chemical Co.,Ltd.

Product: Carperitide Acetate 89213-87-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-12

Hebei Yanxi Chemical Co., Ltd.

Product: ANP 1-28, HUMAN 89213-87-6
Price: US $40.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10 tons
Release date: 2023-09-18

89213-87-6, ANP 1-28, HUMANRelated Search:

N,N'-Dimethyl-3,3'-dithiodipropionamide ALA-ALA-ALA-ALA-ALA PHE-GLY-GLY ANP 1-28, HUMAN PENTAETHYLENEHEXAMINE PENTAGLYCINE H-ALA-ALA-ALA-TYR-OH H-ALA-ALA-ALA-ALA-ALA-ALA-OH AC-MET-NH2 N-ACETYL-ALA-ALA-ALA 3-[(3-AMINO-3-OXOPROPYL)DITHIO]PROPANAMIDE H-ALA-ALA-TYR-OH URODILATIN HUMAN AC-ILE-NHME H-ALA-ALA-ALA-ALA-OH H-ARG-MET-NH2 ACETATE SALT GLY-ALA-TYR H-GLY-GLY-BETA-ALA-OH

ATRIAL NATRIURETIC PEPTIDE HUMAN

SER-LEU-ARG-ARG-SER-SER-CYS-PHE-GLY-GLY-ARG-MET: O-ASP-ARG-ILE-GLY-ALA-GLN-SER-GLY-LEU-GLY-CYS-ASN-SER-PHE-ARG-TYR[SLRRSSCFGGR-MET: O-DRIGAQSGLGCNSFRY]DISULFIDE BRIDGE CYS7-CYS23.

Carperitide Acetate, carperitida

Atrial Natriuretic Peptide (1-28) (human) (trifluoroacetate salt)

ahANF, Carperitide

H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH

Atrial natriureticpeptide-28 (huMan) (9CI)

Atrial Natriuretic Factor (1-28) (huMan) αhANF, Carperitide

Carperitide Acetate

Atrial Natriuretic Factor (1-28) (human) hydrochloride salt H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH hydrochloride salt (Disulfide bond)

ATRIAL NATRIURETIC PEPTIDE HUMAN, 1-28

ATRIAL NATRIURETIC PEPTIDE 1-28, HUMAN

ATRIAL NATRIURETIC PEPTIDE (1-28), HUMAN, PORCINE

ATRIAL NATRIURETIC FACTOR 1-28, HUMAN

ATRIAL NATRIURETIC FACTOR (1-28) (HUMAN, CANINE)

ATRIAL NATRIURETIC FACTOR (1-28) (HUMAN, PORCINE)

ANP, ALPHA-, HUMAN

ANP HUMAN, 1-28

ANP (HUMAN, 1-28) (PORCINE, BOVINE, CANINE)

ANP 1-28, HUMAN

ANF 1-28, HUMAN

ANF (1-28), HUMAN, PORCINE

SLRRSSCFGGRMDRIGAQSGLGCNSFRY

SLRRSSCFGGRMDRIGAQSGLGCNSFRY (DISULFIDE BRIDGE: 7-23)

SER-LEU-ARG-ARG-SER-SER-CYS-PHE-GLY-GLY-ARG-MET-ASP-ARG-ILE-GLY-ALA-GLN-SER-GLY-LEU-GLY-CYS-ASN-SER-PHE-ARG-TYR

SER-LEU-ARG-ARG-SER-SER-CYS-PHE-GLY-GLY-ARG-MET(O)-ASP-ARG-ILE-GLY-ALA-GLN-SER-GLY-LEU-GLY-CYS-ASN-SER-PHE-ARG-TYR

Carperitide

[MET(O)12]-A-TYPE (ATRIAL) NATRIURETIC PEPTIDE (HUMAN, 1-28)

[MET(O)12]-ANP (HUMAN, 1-28)

atrial natriuretic factor (99-126)

ALPHA-ATRIAL NATRIURETIC PEPTIDE, HUMAN, RECOMBINANT

ALPHA-ANP [1-28] HUMAN, CANINE

ALPHA-ANF (1-28), HUMAN

ALPHA-ATRIAL NATRIURETIC PEPTIDE, HUMAN

H-SER-LEU-ARG-ARG-SER-SER-CYS-PHE-GLY-GLY-ARG-MET-ASP-ARG-ILE-GLY-ALA-GLN-SER-GLY-LEU-GLY-CYS-ASN-SER-PHE-ARG-TYR-OH (DISULFIDE BRIDGE: 7-23)

HANF

A-TYPE (ATRIAL) NATRIURETIC PEPTIDE (HUMAN, 1-28) (PORCINE, BOVINE, CANINE)

ATRIAL NATRIURETIC PEPTIDE, ALPHA-, HUMAN

Atrial natriuretic factor【human】

Atrial natriuretic peptide【porcine】

α-Atriopeptin【human】

α-hANP

Carperitide / Carperitide Acetate

L-Tyrosine, L-seryl-L-leucyl-L-arginyl-L-arginyl-L-seryl-L-seryl-L-cysteinyl-L-phenylalanylglycylglycyl-L-arginyl-L-methionyl-L-α-aspartyl-L-arginyl-L-isoleucylglycyl-L-alanyl-L-glutaminyl-L-serylglycyl-L-leucylglycyl-L-cysteinyl-L-asparaginyl-L-seryl-L-phenylalanyl-L-arginyl-, cyclic (7→23)-disulfi...

Carperitide(ANP(1-28)/human)

Carperitide impurity

ANP 1-28, HUMAN USP/EP/BP

Atrial Natriuretic Factor (1-28) (human), αhANF, Carperitide

carperitida

Carperitide?Acetate (alpha-human atrial natriuretic peptide)

89213-87-6

Biochemicals and Reagents

Amino Acids and Peptides

BioChemical

Peptides

Natriuretic Peptides

peptide