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ANP 1-28, HUMAN

Product Name
ANP 1-28, HUMAN
CAS No.
89213-87-6
Chemical Name
ANP 1-28, HUMAN
Synonyms
Carperitide;ATRIAL NATRIURETIC PEPTIDE HUMAN;SLRRSSCFGGRMDRIGAQSGLGCNSFRY;ATRIAL NATRIURETIC FACTOR (1-28) (HUMAN, PORCINE);HANF;α-hANP;carperitida;ANP HUMAN, 1-28;ANP 1-28, HUMAN;ANF 1-28, HUMAN
CBNumber
CB9116087
Molecular Formula
C127H203N45O39S3
Formula Weight
3080.44
MOL File
89213-87-6.mol
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ANP 1-28, HUMAN Property

Density 
1.55±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Water: 1 mg/ml
form 
A lyophilized powder
Sequence
H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH，(Disulfide bridge: Cys-Cys)
InChIKey
NSQLIUXCMFBZME-VUEHYBQXNA-N
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
24539
Product name
Atrial Natriuretic Peptide (1-28) (human) (trifluoroacetate salt)
Purity
≥95%
Packaging
1mg
Price
$384
Updated
2024/03/01
Tocris
Product number
1906
Product name
AtrialNatriureticFactor(1-28)(human,porcine)
Packaging
1
Price
$367
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA110233
Product name
Atrial Natriuretic Factor (1-28) (human) hydrochloride salt H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH hydrochloride salt (Disulfide bond)
Packaging
500ug
Price
$100
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA110233
Product name
Atrial Natriuretic Factor (1-28) (human) hydrochloride salt H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH hydrochloride salt (Disulfide bond)
Packaging
5mg
Price
$602
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA110233
Product name
Atrial Natriuretic Factor (1-28) (human) hydrochloride salt H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH hydrochloride salt (Disulfide bond)
Packaging
10mg
Price
$1047
Updated
2021/12/16
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ANP 1-28, HUMAN Chemical Properties,Usage,Production

Description

Carperitide is the α-human atrial natriuretic peptide (α-hANP) produced by recombinant technology. It was introduced in Japan as a treatment for acute congestive heart failure (CHF). In dogs with CHF, carperitide significantly reduced the elevated left ventricular end-diastolic pressure and the index of myocardial oxygen consumption (systolic blood pressure x heart rate). In a clinical trial, carperitide was effective in improving hemodynamics and symptoms in 60% of patients with acute CHF. Carperitide was reported to be well tolerated with no significant adverse effects clinically. A beneficial effect on hemodynamics has been reported in chronic heart failure patients. Carperitide is also in clinical trials for maintenance of blood pressure during surgical operations.

Description

Atrial natriuretic peptide (ANP) is an endogenous peptide generated by proteolysis of prepro-ANP that is secreted by cardiomyocytes in the heart. It has effects on the renal and cardiovascular systems that decrease vasoconstriction, inhibit renin secretion, and increase sodium excretion. Human ANP binds to ANP receptors on cultured vascular smooth muscle cells (VSMCs) with a Kd value of approximately 1-2 nM and increases cGMP levels in a dose-dependent manner. It relaxes potassium-induced contraction of isolated canine renal arterial strips when used at concentrations of 10 and 100 ng/ml and dilates renal arteries in anesthetized dogs when used at doses ranging from 10 to 100 ng/kg. In a rat model of heart failure following experimental autoimmune myocarditis, human ANP, via osmotic mini pump for 28 days, decreases cardiomyocyte size as well as the amount of cardiac fibrosis and left ventricular remodeling. ANP (1-28) (human) is a 28 amino acid peptide corresponding to the human protein sequence.

Originator

Suntory (Japan)

Uses

Treatment of decompensated congestive heart failure.

Definition

ChEBI: Carperitide is a polypeptide.

brand name

Daiichi Suntory, Japan.

References

[1] T.GEOFFREY FLYNN  Adolfo J de B  Mercedes L de Bold. The amino acid sequence of an atrial peptide with potent diuretic and natriuretic properties[J]. Biochemical and biophysical research communications, 1983, 117 3: Pages 859-865. DOI: 10.1016/0006-291x(83)91675-3
[2] MAACK T. Role of atrial natriuretic factor in volume control[J]. Kidney international, 1996, 49 6: Pages 1732-1737. DOI: 10.1038/ki.1996.257
[3] YUKIO HIRATA. Specific receptors for atrial natriuretic factor (ANF) in cultured vascular smooth muscle cells of rat aorta[J]. Biochemical and biophysical research communications, 1984, 125 2: Pages 562-568. DOI: 10.1016/0006-291x(84)90576-x
[4] T. ISHIHARA. Vasodilatory and diuretic actions of α-human atrial natriuretic polypeptide (α-hANP)[J]. Life sciences, 1985, 36 12: Pages 1205-1215. DOI: 10.1016/0024-3205(85)90239-5
[5] KOMEI TANAKA. Long-term carperitide treatment attenuates left ventricular remodeling in rats with heart failure after autoimmune myocarditis.[J]. Journal of Cardiovascular Pharmacology, 2009: 232-239. DOI: 10.1097/fjc.0b013e3181b0cf50

ANP 1-28, HUMAN Preparation Products And Raw materials

Raw materials

Preparation Products

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ANP 1-28, HUMAN Suppliers

China 127 Germany 2 United Kingdom 3 United States 11 Global 143
Hangzhou Go Top Peptide Biotech
Tel
15397062932
Email
sales1@gotopbio.com
Country
China
ProdList
2923
Advantage
58
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
Advantage
69
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6003
Advantage
61
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Fax
86-21-61263399
Email
ymbetter@glbiochem.com
Country
China
ProdList
9981
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
7247
Advantage
62
Cellmano Biotech Limited
Tel
0551-65326643 18156095617
Fax
0551-65326641
Email
info@cellmano.com
Country
China
ProdList
1010
Advantage
55
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
Hubei XinyuanShun Chemical Co., Ltd.
Tel
13971561712, 13995564702, 027-50664929
Fax
027-50664927
Email
hbeixys2001@163.com
Country
China
ProdList
3120
Advantage
55
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View Lastest Price from ANP 1-28, HUMAN manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Carperitide 89213-87-6
Price
US $0.00/g
Min. Order
1g
Purity
98%min
Supply Ability
1000g
Release date
2023-01-12
Henan Aochuang Chemical Co.,Ltd.
Product
Carperitide Acetate 89213-87-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-12
Hebei Yanxi Chemical Co., Ltd.
Product
ANP 1-28, HUMAN 89213-87-6
Price
US $40.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10 tons
Release date
2023-09-18

89213-87-6, ANP 1-28, HUMANRelated Search:

N,N'-Dimethyl-3,3'-dithiodipropionamide ALA-ALA-ALA-ALA-ALA PHE-GLY-GLY ANP 1-28, HUMAN PENTAETHYLENEHEXAMINE PENTAGLYCINE H-ALA-ALA-ALA-TYR-OH H-ALA-ALA-ALA-ALA-ALA-ALA-OH AC-MET-NH2 N-ACETYL-ALA-ALA-ALA 3-[(3-AMINO-3-OXOPROPYL)DITHIO]PROPANAMIDE H-ALA-ALA-TYR-OH URODILATIN HUMAN AC-ILE-NHME H-ALA-ALA-ALA-ALA-OH H-ARG-MET-NH2 ACETATE SALT GLY-ALA-TYR H-GLY-GLY-BETA-ALA-OH

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