ChemicalBook > CAS DataBase List > ARG-GLY-ASP-SER

ARG-GLY-ASP-SER

Product Name
ARG-GLY-ASP-SER
CAS No.
91037-65-9
Chemical Name
ARG-GLY-ASP-SER
Synonyms
RGDS;RGDS peptide;ARG-GLY-ASP-SER;RGDS 1/2ACOH 2H2O;L-ARG-GLY-ASP-SER;Arg-Gly-Asp-Ser-OH;H-ARG-GLY-ASP-SER-OH;RGDS/ARG-GLY-ASP-SER;FIBRONECTIN INHIBITOR;Arg-Gly-Asp-Ser, >=98%
CBNumber
CB9117206
Molecular Formula
C15H27N7O8
Formula Weight
433.42
MOL File
91037-65-9.mol
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ARG-GLY-ASP-SER Property

Melting point:
183-187℃
Density 
1.65±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
≥21.65 mg/mL in H2O; insoluble in EtOH; insoluble in DMSO
pka
2.84±0.10(Predicted)
form 
White to off-white powder
color 
White to off-white
Water Solubility 
Soluble in water at 1mg/ml
Sequence
H-Arg-Gly-Asp-Ser-OH
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A9041
Product name
Arg-Gly-Asp-Ser
Purity
≥95% (HPLC)
Packaging
2mg
Price
$82.7
Updated
2024/03/01
Sigma-Aldrich
Product number
03-34-0002
Product name
H-Arg-Gly-Asp-Ser-OH - CAS 91037-65-9 - Calbiochem
Packaging
25mg
Price
$210
Updated
2024/03/01
Alfa Aesar
Product number
J64877
Product name
Arg-Gly-Asp-Ser
Packaging
5mg
Price
$85.2
Updated
2023/06/20
Cayman Chemical
Product number
15359
Product name
RGDS Peptide
Purity
≥95%
Packaging
5mg
Price
$49
Updated
2024/03/01
Cayman Chemical
Product number
15359
Product name
RGDS Peptide
Purity
≥95%
Packaging
10mg
Price
$73
Updated
2024/03/01
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ARG-GLY-ASP-SER Chemical Properties,Usage,Production

Uses

Supports fibroblast attachment

Uses

Arg-Gly-Asp-Ser has been used:

  • to study its effects on cell attachment in rats
  • to analyse the interaction of fibrinogen with erythrocytes occurs through integrin related receptor
  • to pretreat the cells, to assess the role of integrin in the cell attachment process
  • to test its competition with platelet-secreted, nanosheet-adsorbed proteins for binding to glycoprotein IIIa (GPIIIa)

General Description

The tetrapeptide Arg-Gly-Asp-Ser (RGDS) is a key component of the cell attachment domain of fibronectin. The RGDS sequence was found initially to promote the attachment of rat kidney fibroblasts (NRKcells) to fibronectin and synthetic fibronectin peptides coupled to protein-coated plastic. Further investigation indicated that the free RGDS peptide inhibited the attachment of NRK cells to fibronectin coated substrates. The RGDS sequence has been shown to occur in several other proteins, such as the λ receptor on E. coli and the Sindbis coat protein. RGDS is also a target sequence for spirochete adherence of the syphilis bacterium Treponema pallidum.

RGDS has been shown to block fibrinogen-induced aggregation of intact erythrocytes and specific binding of fibrinogen to erythrocyte membranes. The effect of RGDS on transforming growth factor ?1 (TGF?1) mRNA expression and secretion in cultured human mesangial cells has been investigated. RGDS has been utilized in a study of integrin-mediated signal transduction in cultured cells from the sponge Suberites domuncula. RGDS has been demonstrated
to mitigate the binding of Mycobacterium tuberculosis to murine alveolar macrophages

Biological Activity

rgds peptide contains the rgd motif which is an antagonist of integrin [1, 2].integrins are cell-surface receptors that recognize rgd motifs present in various extracellular matrix proteins such as fibronectin, vitronectin, laminin, fibrinogen, von willebrand factor, osteopontin, thrombospondin, and collagen as well as in disintegrins. integrins activation triggers different signals regulating cell adhesion, migration, survival, apoptosis as well as processes such as angiogenesis, thrombosis and osteoporosis [1].in sk-mel-110 cells, rgds at 500 μg/ml significantly inhibited melanoma cells proliferation induced by human fibroblast growth factor-2 (fgf-2). furthermore, rgds treatment (48 h, 500 μg/ml) increased the percentage of cells in sub-g1-phase from 3% (with fgf-2 alone) to 13.2% (with fgf-2 and rgds), indicating that rgds might induce apoptosis in melanoma cells, in the presence of fgf-2 [1].in a guinea pig model of allergic asthma, topical treatment of the airways with intranasally instilled rgds (2.5 mm, 200 μl) attenuated allergen-induced airway smooth muscle hyperplasia and hypercontractility as well as increased pulmonary expression of smooth muscle myosin heavy chain and the proliferative marker proliferating cell nuclear antigen [2].[1]. aguzzi m s, fortugno p, giampietri c, et al. intracellular targets of rgds peptide in melanoma cells. molecular cancer, 2010, 9(84): 1-10.[2]. dekkers b g, bos i s, gosens r, et al. the integrin-blocking peptide rgds inhibits airway smooth muscle remodeling in a guinea pig model of allergic asthma. american journal of respiratory and critical care medicine, 2010, 181(6): 556-565.

storage

Store at -20°C

ARG-GLY-ASP-SER Preparation Products And Raw materials

Raw materials

Preparation Products

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ARG-GLY-ASP-SER Suppliers

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View Lastest Price from ARG-GLY-ASP-SER manufacturers

Career Henan Chemical Co
Product
ARG-GLY-ASP-SER 91037-65-9
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2020-02-18
GenicBio Limited
Product
Arg-Gly-Asp-Ser
Price
US $1.00/MG
Min. Order
5MG
Purity
>98%
Supply Ability
5mg,10mg,25mg,100mg,1g,10g
Release date
2018-07-29

91037-65-9, ARG-GLY-ASP-SERRelated Search:

ACDCRGDCFCG (DISULFIDE BRIDGE: 2-10 AND 4-8) H-ARG-GLY-ASP-CYS-OH H-ARG-GLY-ASP-SER-PRO-ALA-SER-SER-LYS-PRO-OH,ARG-GLY-ASP-SER-PRO-ALA-SER-SER-LYS-PRO ARG-GLY-ASP-THR ARG-GLY-ASP-SER GLY-ARG-GLY-ASP-SER-PRO-LYS,H-GLY-ARG-GLY-ASP-SER-PRO-LYS-OH,GLY-ARG-GLY-ASP-SER-PRO-LYS ACETATE CYCLO(-GLY-ARG-GLY-ASP-SER-PRO) H-GLY-ARG-GLY-ASP-SER-NH2 SAR-ARG-GLY-ASP-SER-PRO,SAR-ARG-GLY-ASP-SER-PRO-OH GLY-ARG-GLY-ASP-SER-PRO,H-GLY-ARG-GLY-ASP-SER-PRO-OH H-GLY-ARG-GLY-ASP-SER-CYS-OH GLY-ARG-GLY-ASP-SER-PRO-CYS,H-GLY-ARG-GLY-ASP-SER-PRO-CYS-OH (COUPLED TO BSA) AC-ASP-ARG-GLY-ASP-SER,AC-ASP-ARG-GLY-ASP-SER-OH H-TYR-ARG-GLY-ASP-SER-OH,TYR-ARG-GLY-ASP-SER ARG-PHE-ASP-SER H-ASP-ARG-GLY-ASP-SER-OH,ASP-ARG-GLY-ASP-SER H-GLY-ARG-GLY-ASP-SER-OH,GLY-ARG-GLY-ASP-SER ACETATE,GLY-ARG-GLY-ASP-SER,GLY-ARG-GLY-ASP-SER 1/2ACOH 2H2O DRLDS

  • Fibronectin tetrapeptide
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  • L-Serine, N-(N-(N-L-arginylglycyl)-L-alpha-aspartyl)-
  • arginyl-glycyl-aspartyl-serine
  • RGDS
  • RGDS 1/2ACOH 2H2O
  • L-Serine,N-[N-(N-L-arginylglycyl)-L-a-aspartyl]-
  • L-Serine,L-arginylglycyl-L-a-aspartyl-
  • Arg-Gly-Asp-Ser, >=98%
  • RGDS PEPTIDE;FIBRONECTIN INHIBITOR
  • H-Arg-Gly-Asp-Ser-OH - CAS 91037-65-9 - Calbiochem
  • Arg-Gly-Asp-Ser, ≥95%(HPLC)
  • L-ARG-GLY-ASP-SER
  • H-ARG-GLY-ASP-SER-OH
  • FIBRONECTIN ATTACHMENT PEPTIDE
  • FIBRONECTIN INHIBITOR
  • ARG-GLY-ASP-SER
  • ARG-GLY-ASP-SER 1/2ACOH 2H2O
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  • Arg-Gly-Asp-Ser-OH
  • L-Arg-Gly-L-Asp-L-Ser-OH
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  • 91037-65-9
  • C15H27N7O8
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