Ganciclovir Mono-O-acetate

Product Name: Ganciclovir Mono-O-acetate
CAS No.: 88110-89-8
Chemical Name: Ganciclovir Mono-O-acetate
Synonyms: Monacetyl ganciclor;Gancyclovir Impurity 20;Mono acetyl Ganciclovir;Valganciclovir USP RC E;Ganciclovir Impurity 30;O-Monoacetylganciclovir;Ganciclovir Impurity 16;Mono-O-AcetylGanciclovir;Mono-O-acetateGanciclovir;Ganciclovir Mono-O-acetate
CBNumber: CB91176343
Molecular Formula: C11H15N5O5
Formula Weight: 297.27
MOL File: 88110-89-8.mol

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Ganciclovir Mono-O-acetate Property

Melting point:: 194-197°C
Density: 1.66±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 9.32±0.20(Predicted)
color: White

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H340May cause genetic defects

H351Suspected of causing cancer

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: G235010
Product name: GanciclovirMono-O-acetate
Packaging: 25mg
Price: $185
Updated: 2021/12/16

AK Scientific

Product number: 1320EM
Product name: GanciclovirMono-O-acetate
Packaging: 1g
Price: $69
Updated: 2021/12/16

ChemScene

Product number: CS-M3368
Product name: 2-[(2-Amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-acetoxy-1-propanol
Purity: 97.29%
Packaging: 25g
Price: $71
Updated: 2021/12/16

ChemScene

Product number: CS-M3368
Product name: 2-[(2-Amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-acetoxy-1-propanol
Purity: 97.29%
Packaging: 100g
Price: $214
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0000578
Product name: GANCICLOVIR MONO-O-ACETATE
Purity: 95.00%
Packaging: 50MG
Price: $721.88
Updated: 2021/12/16

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Ganciclovir Mono-O-acetate Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

Ganciclovir derivative.

Synthesis

2466-76-4

82410-32-0

88110-89-8

The general procedure for the synthesis of 2-((2-amino-6-oxo-1H-purin-9(6H)-yl)methoxy)-3-hydroxypropyl acetate from 1-acetylimidazole and 2-amino-9-(((1,3-dihydroxypropan-2- yl)oxy)methyl)-1H-purin-6(9H)-one is as follows: 500.0 g (1.96 mol, 1.0 equiv) of ganciclovir, 244.4 g (2.35 mol, 1.2 eq.) of trimethyl borate and 7.5 kg of toluene were added to the reaction vessel and heated to reflux for 5 hours. The progress of the reaction was monitored by TLC to confirm the complete reaction of the ingredients. The reaction mixture was cooled to room temperature and 396.7 g (3.93 mol, 2.0 eq.) of triethylamine was added, followed by 323.7 g (2.94 mol, 1.5 eq.) of 1-acetylimidazole, and stirred for 6 hours at room temperature. The ratio of monoacetyl ganciclovir to N,O-diacetyl ganciclovir was analyzed by HPLC to be 94:4. The reaction mixture was cooled to 0-10 °C and 2.0 kg of methanol was slowly added dropwise followed by stirring for 2 h at room temperature. The solvent was removed by concentration under reduced pressure, 3.0 kg of ethyl acetate was added, the organic layer was washed with 500 g of water and the aqueous layer was extracted with 500 g of ethyl acetate. The organic layers were combined, concentrated under reduced pressure and recrystallized by ethanol to give 440.9 g of colorless crystal product in 75.7% yield and 99.2% purity.

References

[1] Patent: CN108383840, 2018, A. Location in patent: Paragraph 0033; 0034; 0043; 0045; 0050
[2] Patent: CN108503642, 2018, A. Location in patent: Paragraph 0028-0034; 0039; 0040; 0042-0050; 0053; 0054
[3] Patent: CN108503641, 2018, A. Location in patent: Paragraph 0030; 0031; 0033; 0034; 0040-0051; 0054; 0055
[4] Patent: CN108409739, 2018, A. Location in patent: Paragraph 0033; 0034; 0043; 0045; 0050

Ganciclovir Mono-O-acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ganciclovir Mono-O-acetate Suppliers

Canada 1 China 132 India 12 United States 7 Global 152

Hubei Soren Technology Co., Ltd

Tel: 13419562052 13419562052
Email: wwmlyb@163.com
Country: China
ProdList: 3932
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J & K SCIENTIFIC LTD.

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Jia Xing Isenchem Co.,Ltd

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Adamas Reagent, Ltd.

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Chemsky（shanghai）International Co.,Ltd.

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Haoyuan Chemexpress Co., Ltd.

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Bsisun HK Imoprt And Export Company Limited

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Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
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AdooQ BioScience, LLC

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Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
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ProdList: 39966
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View Lastest Price from Ganciclovir Mono-O-acetate manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: Ganciclovir Mono-O-acetate 88110-89-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2024-11-13

PNP Biotech Co. Ltd

Product: Ganciclovir Mono-O-acetate 88110-89-8
Price: US $0.00/kg
Min. Order: 25kg
Purity: 98%-99%
Supply Ability: Inquiry
Release date: 2022-09-16

Hangzhou ICH Biofarm Co., Ltd

Product: Ganciclovir Mono-O-acetate 88110-89-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99.0%min
Supply Ability: 10tons
Release date: 2023-07-12

88110-89-8, Ganciclovir Mono-O-acetateRelated Search:

Acyclovir N-Methyl-L-valinate Hydrochloride N-Methyl Valganciclovir Hydrochloride N-ForMyl Valacyclovir L-Valine 2-Hydroxyethyl Ester 4-Methylbenzenesulfonate Guanine (S)-Valganciclovir DiMethyl Ether IMpurity DISCONTINUED Cbz-Valaciclovir Bis Valacyclovir (~90%) Bis(L-Valine) Ester Ganciclovir TFA Salt Acyclovir N-Methylene Dimer DVCUGHHGLKCBMT-QVDQXJPCSA-N Valganciclovir Dimer Stereoisomer A, B, C 9-[[2-(α-L-Alanyloxy)ethoxy]methyl]guanine Hydrochloride INDEX NAME NOT YET ASSIGNED Valaciclovir iMpurity D D-Valganciclovir Hydrochloride 9-(1,3-diacetate-2-propoxymethyl)guanine ZCDDBUOENGJMLV-DDWIOCJRSA-N

9-[[2-(Acetyloxy)-1-(hydroxymethyl)ethoxy]methyl]-2-amino-1,9-dihydro- 6H-Purin-6-on

Ganciclovir Mono-O-acetate

Gancyclovir Impurity 20

6h-purin-6-one,9-[[2-(acetyloxy)-1-(hydroxymethyl)ethoxy]methyl]-2-amino-1,9-dihydro-

[2-[(2-amino-6-oxo-3H-purin-9-yl)methoxy]-3-hydroxypropyl] acetate

9-[[2-(Acetyloxy)-1-(hydroxymethyl)ethoxy]methyl]-2-amino-1,9-dihydro- 6H-Purin-6-one

Ganciclovir-Mono-O-acetate(Mono-O-AcetylGanciclovir)

2-[(2-aMino-6-oxo-3,6-dihydro-9H-purin-9-yl)Methoxy]-3-hydroxypropyl acetate

2-[(2-Amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-acetoxy-1-propanol

Mono-O-acetateGanciclovir

Mono acetyl Ganciclovir

Mono-O-AcetylGanciclovir

Mono-O-acetateGanciclovir(Impuritycontrol)

Valganciclovir USP RC E

2-((2-amino-6-oxo-1H-purin-9(6H)-yl)methoxy)-3-hydroxypropyl acetate

Ganciclovir Mono-O-acetate ISO 9001：2015 REACH

valganciclovirhydrochloride iMpurit E

Monacetyl ganciclor

Ganciclovir Impurity 30

Valganciclovir Related Compound E (Monoacetoxy Ganciclovir)

2-[(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)methoxy]-3-hydro...

3-(((1,3-dihydroxypropan-2-yl)oxy)methyl)-6,7-dihydroxy-3,5,6,7- tetrahydro-9H-imidazo[1,2-a]purin-9-one

O-Monoacetylganciclovir

Ganciclovir Impurity 16

2(R,S)-(2-Amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-3-acetoxy-1-propanol

Valganciclovir EP Impurity E

Valganciclovir Hydrochloride Impurity: 9-[[2-(Acetyloxy)-1-(hydroxymethyl)ethoxy]methyl]-2-amino-1,9-dihydro-6H-Purin-6-one (Monoacetoxy ganciclovir)

88110-89-8

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