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Moxestrol

Product Name
Moxestrol
CAS No.
34816-55-2
Chemical Name
Moxestrol
Synonyms
RU-2858;Surestryl;MOXESTROL USP/EP/BP;(17R)-11β-Methoxy-19-norpregna-1,3,5(10)-trien-20-yne-3,17-diol;1, 3, 5(10)-ESTRATRIEN-17α-ETHYNYL-3, 11β, 17β-TRIOL 11-METHYL ETHER;19-Norpregna-1,3,5(10)-trien-20-yne-3,17-diol, 11-methoxy-, (11β,17α)-
CBNumber
CB91179243
Molecular Formula
C21H26O3
Formula Weight
326.43
MOL File
34816-55-2.mol
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Moxestrol Property

Melting point:
280°
alpha 
D20 +29° (c = 0.6 in ethanol)
Boiling point:
404.46°C (rough estimate)
Density 
1.1348 (rough estimate)
refractive index 
1.4700 (estimate)
pka
10.16±0.70(Predicted)
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Hazard and Precautionary Statements (GHS)

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Moxestrol Chemical Properties,Usage,Production

Originator

Surestryl,Roussel,France,1974

Definition

ChEBI: Moxestrol is a 3-hydroxy steroid.

Manufacturing Process

(A) Preparation of 11β-Methoxy-?4,9-Estradiene-3,17-Dione: 0.5 g of ?4,9- estradiene-11β-ol-3,17-dione were dissolved at room temperature in 25 cc of methylene chloride containing 2% of methanol and after 5 mg of p-toluenesulfonic acid were added, the reaction mixture was agitated for several minutes. Then the reaction mixture was poured into ice water, washed with water until the wash waters were neutral, and distilled to dryness under vacuum. The resulting residue was crystallized from ethyl ether to obtain 0.46 g of 11β-methoxy-?4,9-estradiene-3,17-dione having a MP of 140°C.
(B) Preparation of 11β-Methoxy-?1,3,5(10)-Estradiene-3-ol-17-one: 12.3 g of 11β-methoxy-?4,9-estradiene-3,17-dionewere dissolved in 1,230 cc of methanol and then, under an atmosphere of nitrogen, 7.38 g of palladium hydroxide were added and the mixture was held at reflux for one hour under agitation and a nitrogen atmosphere. Then the reaction mixture was cooled to 30°C, filtered, vacuum filtered and washed with methanol. The methanolic solutions were concentrated to about 50 cc, allowed to stand overnight at room temperature and filtered. The precipitate formed was triturated in methanol and dried at 80°C to obtain 10.74 g (yield = 87.5%) of 11β- methoxy-?1,3,5(10)-estradiene-3-ol-17-one having a MP of 264°C.
(C)Preparation of 11β-Methoxy-17α-Ethynyl-?1,3,5(10)-Estradiene-3,17β-Diol: Under agitation and an atmosphere of nitrogen, 12 g of potassium were heated at 80°C in 180 cc of tertiary-amyl alcohol. The mixture was agitated for 30 minutes, cooled to 20°C and after 60 cc of dioxane were added thereto, a stream of acetylene was allowed to bubble through the mixture for one hour and fifteen minutes. Then a solution of 3 g of 11β-methoxy-?1,3,5(10)- estradiene-3-ol-17-one in 50 cc of dioxane was added and the mixture was agitated for 4 hours while continuing the passage of acetylene at room temperature. Thereafter, 50 cc of a 50% aqueous acetic acid solution was added and the mixture was poured into water and extracted with ether. The organic phases were washed first with an aqueous solution containing 10% of neutral sodium carbonate, then with water until the wash waters were neutral, dried over sodium sulfate and concentrated under vacuum until crystallization started. The reaction mixture was iced for one hour, vacuum filtered and the precipitate dried under vacuum to obtain 3.8 g of the raw 17α-ethynyl derivative, which was purified by dissolution in ethyl acetate at reflux and by icing to obtain 2.33 g (yield = 77%) of 11β-methoxy-17α-ethynyl-?1,3,5(10)- estradiene-3,17β-diol, having a MP of 280°C.

Therapeutic Function

Estrogen

Moxestrol Preparation Products And Raw materials

Raw materials

Preparation Products

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Moxestrol Suppliers

TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
19892
Advantage
58
Dideu Industries Group Limited
Tel
+86-29-89586680 +86-15129568250
Email
1026@dideu.com
Country
China
ProdList
29831
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
+86-029-89586680 +86-18192503167
Fax
+86-29-88380327
Email
1026@dideu.com
Country
China
ProdList
9802
Advantage
58
Career Henan Chemica Co
Tel
+86-0371-86658258 15093356674;
Fax
0371-86658258
Email
laboratory@coreychem.com
Country
China
ProdList
30255
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24131
Advantage
58
Shanghai Saikerui Biotechnology Co. , Ltd.
Tel
021-58000709 15900491054
Email
info@scrbio.com
Country
China
ProdList
9260
Advantage
58
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View Lastest Price from Moxestrol manufacturers

Dideu Industries Group Limited
Product
MOXESTROL
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-06-11

34816-55-2, MoxestrolRelated Search:


  • (17R)-11β-Methoxy-19-norpregna-1,3,5(10)-trien-20-yne-3,17-diol
  • RU-2858
  • Surestryl
  • MOXESTROL USP/EP/BP
  • 19-Norpregna-1,3,5(10)-trien-20-yne-3,17-diol, 11-methoxy-, (11β,17α)-
  • 1, 3, 5(10)-ESTRATRIEN-17α-ETHYNYL-3, 11β, 17β-TRIOL 11-METHYL ETHER
  • 34816-55-2