Nisoxetine
- Product Name
- Nisoxetine
- CAS No.
- 53179-07-0
- Chemical Name
- Nisoxetine
- Synonyms
- Nisoxetine;Compound 89218;Benzenepropanamine, γ-(2-methoxyphenoxy)-N-methyl-;[3-(2-Methoxy-phenoxy)-3-phenyl-propyl]-methyl-amine
- CBNumber
- CB91179324
- Molecular Formula
- C17H21NO2
- Formula Weight
- 271.36
- MOL File
- 53179-07-0.mol
Nisoxetine Property
- Boiling point:
- 404.8±40.0 °C(Predicted)
- Density
- 1.054±0.06 g/cm3(Predicted)
- pka
- 10.16±0.10(Predicted)
N-Bromosuccinimide Price
- Product number
- API0008725
- Product name
- NISOXETINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.56
- Updated
- 2021/12/16
Nisoxetine Chemical Properties,Usage,Production
Uses
Antidepressant.
Definition
ChEBI: Nisoxetine is a secondary amino compound that is N-methyl-3-phenylpropan-1-amine substituted at position 3 by a 2-methoxyphenoxy group. It has a role as an antidepressant and an adrenergic uptake inhibitor. It is an aromatic ether and a secondary amino compound.
General Description
Nisoxetine is a SNERI and is an antidepressant. Most activityresides in the β-isomer.
Clinical Use
Nisoxetine was the initial phenoxyphenylpropylamine synthesized in the Lilly research laboratories during the early 1970s from the rearrangement of an oxygen atom in diphenyhydramine, a diphenylmethoxyethylamine, to a phenoxyphenylpropylamine. Nisoxetine was discovered to be a potent and very selective SNRI, with little affinity for other receptors. It underwent clinical studies as an alternative to Lilly's best-selling antidepressant, nortriptyline, but without the adverse effects associated with the tricyclic secondary amines. It was never marketed, however, because of a greater interest in developing its 4-trifluoromethyl analogue, fluoxetine, an SSRI.
Nisoxetine Preparation Products And Raw materials
Raw materials
Preparation Products
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