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NISOXETINE HYDROCHLORIDE

Product Name
NISOXETINE HYDROCHLORIDE
CAS No.
57754-86-6
Chemical Name
NISOXETINE HYDROCHLORIDE
Synonyms
LY-94,939;Nsc298819;NisoxetineHCl;NISOXETINE HYDROCHLORIDE;Nisoxetine hydrochloride[N151];LY-94939; NSC298819; NISOXETINE HCL;4-((2-Nitrophenyl)thio)-2H-oxete hydrochloride;NISOXETINE HYDROCHLORIDE (LY-94,939) NOR PINEPHRINE UPTAKE;Nisoxetine hydrochloride, norepinephrine reuptake (NET) inhibitor;(±)-γ-(2-methoxyphenoxy)-n-methyl-benzenepropanamine hydrochloride
CBNumber
CB9267088
Molecular Formula
C17H22ClNO2
Formula Weight
307.82
MOL File
57754-86-6.mol
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NISOXETINE HYDROCHLORIDE Property

storage temp. 
Sealed in dry,Room Temperature
solubility 
H2O: 20 mg/mL
form 
solid
color 
white
Water Solubility 
Soluble to 100 mM in water
InChI
InChI=1S/C17H21NO2.ClH/c1-18-13-12-15(14-8-4-3-5-9-14)20-17-11-7-6-10-16(17)19-2;/h3-11,15,18H,12-13H2,1-2H3;1H
InChIKey
LCEURBZEQJZUPV-UHFFFAOYSA-N
SMILES
C(CCNC)(OC1=CC=CC=C1OC)C1C=CC=CC=1.Cl
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Safety

Safety Statements 
22-26-36
WGK Germany 
3
RTECS 
NI2922170
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
N151
Product name
Nisoxetine hydrochloride
Purity
solid, ≥98% (HPLC)
Packaging
25mg
Price
$388
Updated
2025/07/31
Sigma-Aldrich
Product number
N151
Product name
Nisoxetine hydrochloride
Purity
solid, ≥98% (HPLC)
Packaging
100mg
Price
$1170
Updated
2025/07/31
Cayman Chemical
Product number
29637
Product name
Nisoxetine (hydrochloride)
Packaging
5mg
Price
$85
Updated
2024/03/01
Cayman Chemical
Product number
29637
Product name
Nisoxetine (hydrochloride)
Packaging
10mg
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
29637
Product name
Nisoxetine (hydrochloride)
Packaging
25mg
Price
$250
Updated
2024/03/01
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NISOXETINE HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

Nisoxetine Hydrochloride is a selective and potent inhibitor of norepinephrine transporter.

Biological Activity

A potent and selective inhibitor of noradrenalin uptake with little or no affinity for a range of other neurotransmitter receptors.

Biochem/physiol Actions

Nisoxetine?is a selective and potent noradrenaline reuptake inhibitor. It has a high affinity towards the noradrenaline transporter. Nisoxetine possesses antidepressant activity.

in vivo

Nisoxetine (2.2 μM; a single intrathecal injection) hydrochloride shows 100, 100, and 100% of blockades in motor function, proprioception, and with duration of action of about 61, 96, and 236 min, respectively[3].
Nisoxetine (3,10, 30 mg/kg, i.p.) hydrochloride inhibits refeeding response (intake of standard chow) in rats[4].

Animal Model:Sprague-Dawley rats(290-340 g)[3]
Dosage:0.6, 1.2, 1.8, 2.2 μM
Administration:A single intrathecal injection
Result:Showed ED50s of 0.82, 0.75 and 0.70 μM in blocking motor function, proprioception, and nociception respectively.

storage

Store at RT

NISOXETINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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NISOXETINE HYDROCHLORIDE Suppliers

China 51 Germany 2 Switzerland 1 United Kingdom 3 United States 14 Global 71
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
Tel
024-024-024-88590548 18341751992
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757984502@qq.com
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China
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3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037
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86-21-50328109
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3bsc@sina.com
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China
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Sigma-Aldrich
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021-61415566 800-8193336
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orderCN@merckgroup.com
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China
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BOC Sciences
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16314854226
Email
info@bocsci.com
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United States
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Pharmacodia (Beijing) Co.,Ltd
Tel
+86-400-851-9921
Fax
+86-10-82826195
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sales@pharmacodia.com
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China
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
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Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
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China
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71826
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Amadis Chemical Company Limited
Tel
571-89925085
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0086-571-89925065
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sales@amadischem.com
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China
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131957
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Lynnchem
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86-(0)29-85992781 17792393971
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info@lynnchem.com
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China
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Novachemistry
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44-20819178-90 02081917890
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(0)2080432064
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info@novachemistry.com
Country
United Kingdom
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4381
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57754-86-6, NISOXETINE HYDROCHLORIDERelated Search:

Levofloxacin hydrochloride Difenidol hydrochloride Nicardipine hydrochloride Nisoxetine (2RS,3RS)-1-CHLOROACETYLAMINO-3-(2-ETHOXY-D5-PHENOXY)-2-HYDROXY-3-PHENYLPROPANE Piperazine, 1-(3-(2-ethoxyphenoxy)-3-phenylpropyl)-4-(phenylmethyl)-, hydrochloride, hydrate (1:2:1) NISOXETINE HYDROCHLORIDE (2RS,3RS)-1-CHLOROACETYLAMINO-3-(2-ETHOXYPHENOXY)-2-HYDROXY-3-PHENYLPROPANE NISOXETINE HYDROCHLORIDE, [N-METHYL-3H]-

  • LY-94,939
  • (+/-)-GAMMA-(2-METHOXYPHENOXY)-N-METHYL-BENZENEPROPANAMINE HYDROCHLORIDE
  • NISOXETINE HYDROCHLORIDE
  • NISOXETINE HYDROCHLORIDE (LY-94,939) NOR PINEPHRINE UPTAKE
  • (+/-)-g-(2-Methoxyphenoxy)-N-methylbenzenepropanaminehydrochloride
  • NisoxetineHCl
  • Nsc298819
  • (±)-γ-(2-methoxyphenoxy)-n-methyl-benzenepropanamine hydrochloride
  • LY-94,939, (±)-γ-(2-Methoxyphenoxy)-N-methyl-benzenepropanamine hydrochloride
  • 4-((2-Nitrophenyl)thio)-2H-oxete hydrochloride
  • LY-94939; NSC298819; NISOXETINE HCL
  • 3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-amine hydrochloride
  • noradrenaline,channels,Monoamine Transporter,uptake,anesthetic,Inhibitor,Nisoxetine hydrochloride,Na channels,sodium,Nisoxetine,local,NET,antidepressant,Na+ channels,depression,Sodium Channel,transporter,inhibit
  • Nisoxetine hydrochloride, norepinephrine reuptake (NET) inhibitor
  • Nisoxetine hydrochloride[N151]
  • 57754-86-6
  • C17H21NO2HCl
  • Potent and selective inhibitor of the norepinephrine transporter (Ki = 5.1 nM).
  • Adrenoceptor