Quiflapon
- Product Name
- Quiflapon
- CAS No.
- 136668-42-3
- Chemical Name
- Quiflapon
- Synonyms
- MK 0591;L-686708;Quiflapon;MK 591(Quiflapon);MK-0591 (Quiflapon);Quiflapon, 10 mM in DMSO;QUIFLAPON;MK-591;L-686708;QUIFLAPON; MK0591; MK 0591;MK591,FLAP,inhibit,5-LO activating protein,Quiflapon,MK 591,Inhibitor,Apoptosis;3-(3-(tert-Butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-yl)-2,2-dimethylp
- CBNumber
- CB91179632
- Molecular Formula
- C34H35ClN2O3S
- Formula Weight
- 587.17
- MOL File
- 136668-42-3.mol
Quiflapon Property
- Boiling point:
- 751.3±60.0 °C(Predicted)
- Density
- 1.21±0.1 g/cm3(Predicted)
- solubility
- Soluble in DMSO
- form
- Powder
- pka
- 4.70±0.10(Predicted)
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- CS-0953
- Product name
- Quiflapon
- Purity
- 99.44%
- Packaging
- 5mg
- Price
- $156
- Updated
- 2021/12/16
- Product number
- A3609
- Product name
- MK-0591
- Packaging
- 5mg
- Price
- $190
- Updated
- 2021/12/16
- Product number
- CS-0953
- Product name
- Quiflapon
- Purity
- 99.44%
- Packaging
- 10mg
- Price
- $210
- Updated
- 2021/12/16
- Product number
- A3609
- Product name
- MK-0591
- Packaging
- 10mg
- Price
- $256
- Updated
- 2021/12/16
- Product number
- orb611863
- Product name
- MK-0591
- Purity
- >98%
- Packaging
- 10mg
- Price
- $374
- Updated
- 2021/12/16
Quiflapon Chemical Properties,Usage,Production
Uses
Anti-asthmatic; suppressant (inflammatory bowel disease).
in vivo
Quiflapon is a potent inhibitor of LT biosynthesis in vivo, first, following ex vivo challenge of blood obtained from treated rats and squirrel monkeys, second, in a rat pleurisy model, and, third, as monitored by inhibition of the urinary excretion of LTE4 in antigen-challenged allergic sheep. Inhibition of antigen-induced bronchoconstriction by Quiflapon is observed in inbred rats pretreated with methysergide, Ascaris-challenged squirrel monkeys, and Ascaris-challenged sheep (early and late phase response) [1]. Pups were treated with either vehicle or Quiflapon 10, 20, or 40 mg/kg subcutaneously daily for days 1-4, 5-9, or 10-14. On day 14, the lungs were inflated, fixed, and stained for histopathological and morphometric analyses. Hyperoxia groups treated with Quiflapon untreated hyperoxia groups showed definite evidence of aberrant alveolarization but no inflammation[2].
target
FLAP
Quiflapon Preparation Products And Raw materials
Raw materials
Preparation Products
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