6-BROMO-3 H-ISOBENZOFURAN-1-ONE
- Product Name
- 6-BROMO-3 H-ISOBENZOFURAN-1-ONE
- CAS No.
- 19477-73-7
- Chemical Name
- 6-BROMO-3 H-ISOBENZOFURAN-1-ONE
- Synonyms
- 6-Bromophthalide;Roxadustat Impurity 12;6-bromo-1(3H)-isobenzofuanone;6-bromo-1H-isobenzofuran-1-one;6-bromo-2-benzofuran-1(3H)-one;6-BROMO-3 H-ISOBENZOFURAN-1-ONE;1(3H)-Isobenzofuranone, 6-broMo-;6-broMo-1,3-dihydro-2-benzofuran-1-one;1(3H)-Isobenzofuranone, 6-bromo-, 97%min
- CBNumber
- CB9119987
- Molecular Formula
- C8H5BrO2
- Formula Weight
- 213.03
- MOL File
- 19477-73-7.mol
6-BROMO-3 H-ISOBENZOFURAN-1-ONE Property
- Melting point:
- 99.5 °C
- Boiling point:
- 362.4±42.0 °C(Predicted)
- Density
- 1.742±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- color
- White to Off-White
- InChI
- InChI=1S/C8H5BrO2/c9-6-2-1-5-4-11-8(10)7(5)3-6/h1-3H,4H2
- InChIKey
- BELKVKMBIAENSA-UHFFFAOYSA-N
- SMILES
- C1(=O)C2=C(C=CC(Br)=C2)CO1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H272May intensify fire; oxidizer
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P220Keep/Store away from clothing/…/combustible materials.
P221Take any precaution to avoid mixing with combustibles/…
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B688668
- Product name
- 6-Bromo-3H-isobenzofuran-1-one
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 074102
- Product name
- 6-Bromo-3H-isobenzofuran-1-one
- Purity
- 95+%
- Packaging
- 1g
- Price
- $59
- Updated
- 2021/12/16
- Product number
- W4155
- Product name
- 6-Bromo-3H-isobenzofuran-1-one
- Packaging
- 1g
- Price
- $67
- Updated
- 2021/12/16
- Product number
- FB142645
- Product name
- 6-Bromo-3H-isobenzofuran-1-one
- Packaging
- 1g
- Price
- $89
- Updated
- 2021/12/16
- Product number
- 026924
- Product name
- 6-Bromo-3H-isobenzofuran-1-one
- Purity
- 95%
- Packaging
- 1g
- Price
- $114
- Updated
- 2021/12/16
6-BROMO-3 H-ISOBENZOFURAN-1-ONE Chemical Properties,Usage,Production
Chemical Properties
Light red crystal
Synthesis
57319-65-0
19477-73-7
Step c: Synthesis of 6-bromoisobenzofuran-1(3H)-one Aqueous (22 mL) solution of NaNO2 (2.2 g, 0.040 mol) was added dropwise to a suspension of 6-aminoisobenzofuran-1(3H)-one (5.0 g, 0.030 mol) in HBr (70 mL, 48%), keeping the reaction temperature at 0 °C. After completion of dropwise addition, stirring of the reaction mixture was continued for 20 min. Subsequently, the reaction solution was transferred to a pre-cooled solution of CuBr (22 g, 0.21 mol) in HBr (48%, 23 mL). The resulting dark brown mixture was stirred for 20 min and then diluted with deionized water (200 mL) to precipitate an orange precipitate. The precipitate was collected by filtration, washed with saturated NaHCO3 solution and subsequently extracted with ethyl acetate (20 mL x 3). The organic phases were combined, dried with anhydrous Na2SO4 and concentrated under reduced pressure to afford 6-bromoisobenzofuran-1(3H)-one (5.4 g, 84% yield). 1H NMR (300 MHz, CDCl3) δ 8.05 (d, J = 1.8 Hz, 1H), 7.80 (dd, J = 8.1, 1.8 Hz, 1H), 7.39 (d, J = 8.1 Hz, 1H), 5.28 (s, 2H).
References
[1] Patent: US2008/9524, 2008, A1. Location in patent: Page/Page column 410
[2] Patent: EP1362856, 2003, A1. Location in patent: Page/Page column 159
[3] Patent: US2015/231142, 2015, A1. Location in patent: Paragraph 1265
[4] Chemistry of Heterocyclic Compounds, 2010, vol. 46, # 2, p. 140 - 145
[5] Journal of Medicinal Chemistry, 2015, vol. 58, # 9, p. 3997 - 4015
6-BROMO-3 H-ISOBENZOFURAN-1-ONE Preparation Products And Raw materials
Raw materials
Preparation Products
6-BROMO-3 H-ISOBENZOFURAN-1-ONE Suppliers
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View Lastest Price from 6-BROMO-3 H-ISOBENZOFURAN-1-ONE manufacturers
- Product
- Roxadustat Impurity 12
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 98%
- Supply Ability
- 500mg
- Release date
- 2024-07-17
- Product
- 6-BROMO-3 H-ISOBENZOFURAN-1-ONE 19477-73-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 6-BROMO-3 H-ISOBENZOFURAN-1-ONE 19477-73-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09