Methyl 4-hydroxy-7-phenoxyisoquinoline-3-carboxylate

Product Name: Methyl 4-hydroxy-7-phenoxyisoquinoline-3-carboxylate
CAS No.: 1455091-10-7
Chemical Name: Methyl 4-hydroxy-7-phenoxyisoquinoline-3-carboxylate
Synonyms: methyl 4-hydroxy-7-phenoxyisoquinoline-3-carboxylate;Roxadustat Impurity 13;3-Isoquinolinecarboxylic acid, 4-hydroxy-7-phenoxy-, methyl ester;ROXA-030;Asiminib;FG-4592 INT;FG4592 intermediates;Roxastat Impurity 14;Roxadustat Impurity 4;FG-4592 interMediate
CBNumber: CB12730014
Molecular Formula: C17H13NO4
Formula Weight: 295.29
MOL File: 1455091-10-7.mol

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Methyl 4-hydroxy-7-phenoxyisoquinoline-3-carboxylate Property

Boiling point:: 534.7±45.0 °C(Predicted)
Density: 1.320±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 5.80±0.50(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C17H13NO4/c1-21-17(20)15-16(19)14-8-7-13(9-11(14)10-18-15)22-12-5-3-2-4-6-12/h2-10,19H,1H3
InChIKey: YTWDBRIDKWWANA-UHFFFAOYSA-N
SMILES: C1C2=C(C=CC(OC3=CC=CC=C3)=C2)C(O)=C(C(OC)=O)N=1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M327103
Product name: Methyl4-Hydroxy-7-phenoxyisoquinoline-3-carboxylate
Packaging: 500mg
Price: $165
Updated: 2021/12/16

AK Scientific

Product number: 6919EA
Product name: Methyl4-hydroxy-7-phenoxyisoquinoline-3-carboxylate
Packaging: 5g
Price: $465
Updated: 2021/12/16

Ambeed

Product number: A110786
Product name: Methyl4-hydroxy-7-phenoxyisoquinoline-3-carboxylate
Purity: 97%
Packaging: 250mg
Price: $53
Updated: 2021/12/16

Chemenu

Product number: CM146104
Product name: methyl4-hydroxy-7-phenoxyisoquinoline-3-carboxylate
Purity: 95+%
Packaging: 1g
Price: $102
Updated: 2021/12/16

Ambeed

Product number: A110786
Product name: Methyl4-hydroxy-7-phenoxyisoquinoline-3-carboxylate
Purity: 97%
Packaging: 1g
Price: $109
Updated: 2021/12/16

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Methyl 4-hydroxy-7-phenoxyisoquinoline-3-carboxylate Chemical Properties,Usage,Production

Uses

Methyl 4-Hydroxy-7-phenoxyisoquinoline-3-carboxylate is an intermediate of N-[(4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]glycine (H948180), a hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor used to increase white blood cell levels in blood and hematopoietic progenitor cells in bone marrow.

Synthesis

1455091-06-1

1455091-10-7

General procedure for the synthesis of methyl 4-hydroxy-7-phenoxyisoquinoline-3-carboxylate from methyl 2-[(methoxycarbonylmethyl)(toluene-4-sulfonyl)amino]methyl-4-phenoxybenzoate: a solution was prepared by dissolving sodium methanolate (12.70 g, 234.60 mmol) in methanol (40 mL) under ice-bath conditions. The solution was slowly added dropwise to a solution of dimethyl sulfoxide (82 mL) containing methyl 2-[(methoxycarbonylmethyl)(toluene-4-sulfonyl)amino]methyl-4-phenoxybenzoate (18.90 g, 39.10 mmol). After dropwise addition, the reaction mixture was continued to be stirred at room temperature for 2 hours. Upon completion of the reaction, methanol was removed by distillation under reduced pressure. The residue was diluted with water (50 mL) and the pH was adjusted to 10 with 1 N dilute hydrochloric acid.Subsequently, the organic layers were combined by extraction with ethyl acetate (100 mL x 3). The organic layer was washed sequentially with water (100 mL) and saturated brine (100 mL) and then dried with anhydrous sodium sulfate. The dried organic phase was concentrated under reduced pressure, and the resulting concentrate was separated and purified by column chromatography, resulting in 9.1 g of white solid product in 78.8% yield.

References

[1] Patent: CN106083720, 2016, A. Location in patent: Paragraph 0062; 0071-0072
[2] Patent: WO2013/134660, 2013, A1. Location in patent: Paragraph 0169

Methyl 4-hydroxy-7-phenoxyisoquinoline-3-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 4-hydroxy-7-phenoxyisoquinoline-3-carboxylate Suppliers

China 227 India 2 United States 2 Global 231

Jiangsu Vcare PharmaTech Co., Ltd.

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Shanghai Kuanghao Chemistry Technology Co., Ltd.

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View Lastest Price from Methyl 4-hydroxy-7-phenoxyisoquinoline-3-carboxylate manufacturers

Anhuyan (Hainan) Biotechnology Co., LTD

Product: Methyl 4-hydroxy-7-phenoxyisoquinoline-3-carboxylate 1455091-10-7
Price: US $0.00-0.00/g
Min. Order: 0.1g
Purity: 99.99%
Supply Ability: 20000t
Release date: 2025-06-16

Zison Pharmaceutical (Shandong) Co., Ltd.

Product: 4-Hydroxy-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester 1455091-10-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: ＞98% by HPLC
Supply Ability: 10kg/month
Release date: 2023-01-09

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Roxadustat Impurity 25
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 98%
Supply Ability: 500mg
Release date: 2024-07-17

1455091-10-7, Methyl 4-hydroxy-7-phenoxyisoquinoline-3-carboxylateRelated Search:

4-Hydroxybenzyl alcohol 6-BROMO-3 H-ISOBENZOFURAN-1-ONE methyl 7-bromo-4-hydroxyisoquinoline-3-carboxylate methyl 4-hydroxy-6-phenoxyisoquinoline-3-carboxylate (R)-9-((triisopropylsilyl)oxy)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-5-onehydrochloride 7,8-dihydro-5H-cyclohepta[b]pyridine-5,9(6H)-dione 2-(2-Methyl-2H-tetrazol-5-yl)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine 1-(1-(1H-imidazole-1-carbonyl)piperidin-4-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one 4-Aminophthalimide 5-Aminophthalide 1(3H)-Isobenzofuranone, 5-phenoxy- INDEX NAME NOT YET ASSIGNED methyl 2-(4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxamido)acetate methyl 1-chloro-4-hydroxy-7-phenoxyisoquinoline-3-carboxylate Roxadustat 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester

Roxadustat Impurity 4

FG-4592 INT

4-hydroxy-7-phenoxyisoquinoline-3-carboxylic acid methyl ester

FG-4592 interMediate

3-Isoquinolinecarboxylic acid, 4-hydroxy-7-phenoxy-, methyl ester

FG4592 intermediates

ROXA-030

4-Hydroxy-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester

methyl 4-hydroxy-7-phenoxyisoquinoline-3-carboxylate

4-Hydroxy-7-phenoxy-3-isoquinolinecarboxylic

Roxadustat Impurity 13

Roxadustat Impurity 25

4-Hydroxy-7-phenoxy-3-isoquinolinecarboxylic acid methyl est...

Roxadustat Impurities3

4-Hydroxy-7-phenoxy ascension quinoline-3-Methyl formate

4-Hydroxy-7-phenoxyisoquinoline-3-Methyl formate

RSYY(Vorapaxar Sulfatet)-5

Rosalistat impurity 4

methyl 4-hydroxy-7-phenoxyisoquinoline-3-carboxylate（FG-4592 interMediate）

Roxastat Impurity 14

ethyl 2-acetyl-4-phenoxybenzoate

Asiminib

1455091-10-7

1055091-10-7

145509-10-7

Intermediate

API