ChemicalBook > CAS DataBase List > 2-(2-Methyl-2H-tetrazol-5-yl)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine

2-(2-Methyl-2H-tetrazol-5-yl)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine

Product Name
2-(2-Methyl-2H-tetrazol-5-yl)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine
CAS No.
1056039-83-8
Chemical Name
2-(2-Methyl-2H-tetrazol-5-yl)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine
Synonyms
TEDIZOLID ITS-3;Tedizolid intermediate H;2-(2-Methyl-2H-tetrazol-5-yl)-5-(4;Pinacol 2-(2-methyl-2H-tetrazol-5-yl)-5-pyridineboronate;2-(2-Methyl-2H-tetrazol-5-yl)pyridine-5-boronic acid pinacol;(2-(2-methyl-2H-tetrazol-5-yl)pyridyl-5-yl)(pinacolato)boron;2-(2-Methyl-2H-tetrazol-5-yl)-5-(4,4,5,5-tetraMethyl-1,3,2-d...;2-(2-Methyl-2H-tetrazol-5-yl)pyridine-5-boronic acid pinacol ester;6-(2-Methyl-2H-tetrazol-5-yl)pyridine-3-boronic Acid Pinacol Ester;2-(2-methyltetrazol-5-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
CBNumber
CB22704919
Molecular Formula
C13H18BN5O2
Formula Weight
287.13
MOL File
1056039-83-8.mol
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2-(2-Methyl-2H-tetrazol-5-yl)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine Property

Boiling point:
450.6±55.0 °C(Predicted)
Density 
1.24±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
1.13±0.10(Predicted)
Appearance
White to off-white Solid
InChI
InChI=1S/C13H18BN5O2/c1-12(2)13(3,4)21-14(20-12)9-6-7-10(15-8-9)11-16-18-19(5)17-11/h6-8H,1-5H3
InChIKey
VOEFRGFXMMXFGK-UHFFFAOYSA-N
SMILES
C1(C2=NN(C)N=N2)=NC=C(B2OC(C)(C)C(C)(C)O2)C=C1
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Safety

HS Code 
2931900090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H228Flammable solid

H302Harmful if swallowed

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P370+P378In case of fire: Use … for extinction.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
M327695
Product name
2-(2-Methyl-2H-tetrazol-5-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
Packaging
1g
Price
$95
Updated
2021/12/16
AK Scientific
Product number
9999AL
Product name
2-(2-Methyl-2H-tetrazol-5-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
Packaging
1g
Price
$104
Updated
2021/12/16
AK Scientific
Product number
9999AL
Product name
2-(2-Methyl-2H-tetrazol-5-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
Packaging
5g
Price
$224
Updated
2021/12/16
ChemScene
Product number
CS-M3230
Product name
Pyridine,2-(2-methyl-2H-tetrazol-5-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
Packaging
10g
Price
$231
Updated
2021/12/16
AK Scientific
Product number
9999AL
Product name
2-(2-Methyl-2H-tetrazol-5-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
Packaging
10g
Price
$317
Updated
2021/12/16
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2-(2-Methyl-2H-tetrazol-5-yl)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine Chemical Properties,Usage,Production

Uses

2-(2-Methyl-2H-tetrazol-5-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine has been used to investigate torezolid -based antibacterial agent.

Synthesis

73183-34-3

380380-64-3

1056039-83-8

To a solution of 2-(2-methyl-tetrazolyl)-5-bromopyridine (1.00 g, 4.17 mmol) in dry degassed 1,4-dioxane (15 mL) was added bis(pinacolato)diboron (1.27 g, 5.00 mmol), potassium acetate (1.35 g, 13.75 mmol), and Pd(dppf)Cl2 (0.26 g, 0.35 mmol). The reaction mixture was placed in a sealed tube under argon protection and heated and stirred at 80°C for 3 hours. Upon completion of the reaction, the mixture was rapidly filtered through a silica gel column and dichloromethane was used as eluent. The organic layer was collected, concentrated under reduced pressure and the residue was washed with hexane to afford the white solid product 2-(2-methyl-2H-tetrazol-5-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (1.03 g, 86.3% yield). The product was characterized by 1H-NMR (400 MHz, CDCl3): δ 9.14 (s, 1H), 8.30 (m, 2H), 4.48 (s, 3H), 1.38 (s, 12H).

References

[1] Chemical and Pharmaceutical Bulletin, 2015, vol. 63, # 2, p. 143 - 146
[2] Patent: WO2008/108988, 2008, A1. Location in patent: Page/Page column 53
[3] European Journal of Organic Chemistry, 2016, vol. 2016, # 7, p. 1305 - 1313
[4] Patent: WO2009/74812, 2009, A1. Location in patent: Page/Page column 41
[5] Patent: US2010/69441, 2010, A1. Location in patent: Page/Page column 21-22

2-(2-Methyl-2H-tetrazol-5-yl)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(2-Methyl-2H-tetrazol-5-yl)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine Suppliers

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Tianjin Chempharmatech Co.,Ltd.
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View Lastest Price from 2-(2-Methyl-2H-tetrazol-5-yl)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
2-(2-Methyl-2H-tetrazol-5-yl)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine 1056039-83-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-30
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-(2-methyl-2h-tetrazol-5-yl)pyridine-5-boronic acid pinacol ester 1056039-83-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-(2-methyl-2h-tetrazol-5-yl)pyridine-5-boronic acid pinacol ester 1056039-83-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

1056039-83-8, 2-(2-Methyl-2H-tetrazol-5-yl)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridineRelated Search:

7,8-dihydro-5H-cyclohepta[b]pyridine-5,9(6H)-dione FG-4592 interMediate 1-(1-(1H-imidazole-1-carbonyl)piperidin-4-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one Phosphoric acid Zoledronic acid 3-(DIMETHYLAMINO)-1-(NAPHTHALEN-1-YL)PROPAN-1-ONE HYDROCHLORIDE 3-benzyl-6-bromo-2-methoxyquinoline 4-Bromo-2-nitroaniline 4-Pyrimidinamine, 2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]- 2,5-Dichloro-N-[2-[(1-methylethyl)thio]phenyl]-4-pyrimidinamine 3-benzyl-6-bromo-2-chloroquinoline 3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one 5-Methyl-2-(1-Methylethoxy)-4- (4-piperidinyl)- BenzenaMine hydrochloride (1:2) (5R)-3-(4-BROMO-3-FLUOROPHENYL)-5-HYDROXYMETHYLOXAZOLIDIN-2-ONE Tedizolid Phosphate CarbaMic acid, N-[3-fluoro-4-[6-(2-Methyl-2H-tetrazol-5-yl)-3-pyridinyl]phenyl]-, phenylMethyl ester 5-BROMO-2-(2-METHYL-2H-TETRAZOL-5-YL)-PYRIDINE Torezolid

  • 2-(2-Methyl-2H-tetrazol-5-yl)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine
  • Tedizolid intermediate H
  • 2-(2-Methyl-2H-tetrazol-5-yl)pyridine-5-boronic acid pinacol ester
  • Pyridine, 2-(2-methyl-2H-tetrazol-5-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
  • 2-(2-Methyl-2H-tetrazol-5-yl)-5-(4
  • 2-(2-Methyl-2H-tetrazol-5-yl)pyridine-5-boronic acid pinacol
  • Pinacol 2-(2-methyl-2H-tetrazol-5-yl)-5-pyridineboronate
  • TEDIZOLID ITS-3
  • 2-(2-methyltetrazol-5-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
  • 2-(2-Methyl-2H-tetrazol-5-yl)-5-(4,4,5,5-tetraMethyl-1,3,2-d...
  • (2-(2-methyl-2H-tetrazol-5-yl)pyridyl-5-yl)(pinacolato)boron
  • 6-(2-Methyl-2H-tetrazol-5-yl)pyridine-3-boronic Acid Pinacol Ester
  • 1056039-83-8
  • C13H18BN5O2
  • Tedizolid intermediates
  • Tedizolid Phosphate
  • 1056039-83-8