3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one

Product Name: 3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one
CAS No.: 10320-49-7
Chemical Name: 3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one
Synonyms: (2-alpha-Naphthoylethyl)dimethylamine;3-(diMethylaMino)-1-(naphthalen-1-yl)pr;2-(Dimethylamino)ethyl 1-naphthyl ketone;3-(Dimethylamino)-1-(1-naphthyl)-1-propanone;3-(dimethylamino)-1-(phthalen-5-yl)propan-1-one;3-(dimethylamino)-1-(1-naphthalenyl)-1-propanone;3-(dimethylamino)-1-(naphthalen-1-yl)propan-1-one;3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one;1-Propanone,3-(dimethylamino)-1-(1-naphthalenyl)-
CBNumber: CB2970905
Molecular Formula: C15H17NO
Formula Weight: 227.3
MOL File: 10320-49-7.mol

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3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one Property

Boiling point:: 368.7±25.0 °C(Predicted)
Density: 1.072
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 8.78±0.28(Predicted)
Appearance: Colorless to light yellow Viscous liquid
InChI: InChI=1S/C15H17NO/c1-16(2)11-10-15(17)14-9-5-7-12-6-3-4-8-13(12)14/h3-9H,10-11H2,1-2H3
InChIKey: CXDXSNWZXJVDMC-UHFFFAOYSA-N
SMILES: C(C1=C2C(C=CC=C2)=CC=C1)(=O)CCN(C)C

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M205300
Product name: 3-(Dimethylamino)-1-(1-Naphthalenyl)-1-Propanone
Packaging: 1g
Price: $525
Updated: 2021/12/16

Matrix Scientific

Product number: 073627
Product name: 3-(Dimethylamino)-1-(naphthalen-5-yl)propan-1-one
Purity: 95+%
Packaging: 1g
Price: $578
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD153888
Product name: 3-(Dimethylamino)-1-(naphthalen-5-yl)propan-1-one
Packaging: 2g
Price: $785
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD153888
Product name: 3-(Dimethylamino)-1-(naphthalen-5-yl)propan-1-one
Packaging: 100mg
Price: $77
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD153888
Product name: 3-(Dimethylamino)-1-(naphthalen-5-yl)propan-1-one
Packaging: 250mg
Price: $152.5
Updated: 2021/12/16

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3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one Chemical Properties,Usage,Production

Uses

3-(Dimethylamino)-1-(1-Naphthalenyl)-1-Propanone is a compound related to TMC207 which is used in the treatment of drug-resistant tuberculosis, and was studied for its anti-tubercular activity.

Synthesis

941-98-0

50-00-0

506-59-2

10320-49-7

1-Acetylnaphthalene (8 g, 0.047 mol), paraformaldehyde (2 g, 0.065 mol) and dimethylamine hydrochloride (5.3 g, 0.065 mol) were dissolved in ethanol (15 mL), followed by the addition of 0.6 mL of concentrated hydrochloric acid. The reaction mixture was heated to reflux for 12 hours, after which it was cooled to room temperature and refrigerated at -20 °C overnight. A white solid precipitated from the reaction mixture, which was separated by filtration and washed with ethanol. The resulting white solid was dissolved in water and 50% aqueous sodium carbonate solution (5.8 g, 0.54 mol) was slowly added. After stirring for 10-15 min, the aqueous phase was extracted with ethyl acetate (20 mL x 3), the organic layers were combined, washed sequentially with water (15 mL x 2) and saturated saline (15 mL x 2), and dried over anhydrous sodium sulfate. After filtration, the solvent was evaporated under reduced pressure to obtain the target compound 3-dimethylamino-1-(naphthalen-5-yl)acetone as a colorless oil (8 g, 70% yield).

References

[1] Chinese Chemical Letters, 2015, vol. 26, # 6, p. 790 - 792
[2] Patent: EP2371819, 2011, A1. Location in patent: Page/Page column 7
[3] Patent: EP2573067, 2013, A1. Location in patent: Paragraph 0065; 0066
[4] Patent: TW2016/4185, 2016, A. Location in patent: Paragraph 0342; 0343
[5] ACS Medicinal Chemistry Letters, 2017, vol. 8, # 10, p. 1019 - 1024

3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one Preparation Products And Raw materials

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3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one Suppliers

China 98 Europe 1 Germany 1 India 2 United Kingdom 1 United States 6 Global 109

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View Lastest Price from 3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one manufacturers

Qingdao RENAS Polymer Material Co., Ltd.

Product: 3-(dimethylamino)-1-(naphthalen-1-yl)propan-1-one 10320-49-7
Price: US $0.00/kg
Min. Order: 20kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2025-04-26

Hebei Chuanghai Biotechnology Co., Ltd

Product: 3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one 10320-49-7
Price: US $10.00/KG
Min. Order: 100KG
Purity: 99%
Supply Ability: 100 mt
Release date: 2024-11-22

Henan Aochuang Chemical Co.,Ltd.

Product: 3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one 10320-49-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

10320-49-7, 3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-oneRelated Search:

3-(DIMETHYLAMINO)-1-(NAPHTHALEN-1-YL)PROPAN-1-ONE HYDROCHLORIDE (5R)-3-(4-BROMO-3-FLUOROPHENYL)-5-HYDROXYMETHYLOXAZOLIDIN-2-ONE CarbaMic acid, N-[3-fluoro-4-[6-(2-Methyl-2H-tetrazol-5-yl)-3-pyridinyl]phenyl]-, phenylMethyl ester 3-benzyl-6-bromo-2-methoxyquinoline 4-Bromo-2-nitroaniline 4-Pyrimidinamine, 2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]- 5-BROMO-2-(2-METHYL-2H-TETRAZOL-5-YL)-PYRIDINE 2,5-Dichloro-N-[2-[(1-methylethyl)thio]phenyl]-4-pyrimidinamine 3-benzyl-6-bromo-2-chloroquinoline 2-(2-Methyl-2H-tetrazol-5-yl)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine 5-Methyl-2-(1-Methylethoxy)-4- (4-piperidinyl)- BenzenaMine hydrochloride (1:2) 1-(1-OXO-2,3-DIHYDRO-1H-CYCLOPENTA-[A]NAPHTHALEN-3-YL)-AZEPAN-2-ONE ALPHA-NETA 1-(1-OXO-2,3-DIHYDRO-1H-CYCLOPENTA[A]-NAPHTHALEN-3-YL)-PYRROLIDIN-2-ONE 3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one

1-Propanone,3-(dimethylamino)-1-(1-naphthalenyl)-

3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one

3-(dimethylamino)-1-(naphthalen-1-yl)propan-1-one

(2-alpha-Naphthoylethyl)dimethylamine

2-(Dimethylamino)ethyl 1-naphthyl ketone

3-(dimethylamino)-1-(phthalen-5-yl)propan-1-one

3-(dimethylamino)-1-(1-naphthalenyl)-1-propanone

3-(diMethylaMino)-1-(naphthalen-1-yl)pr

3-(Dimethylamino)-1-(1-naphthyl)-1-propanone

10320-49-7

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