ChemicalBook > CAS DataBase List > 3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one

3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one

Product Name
3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one
CAS No.
10320-49-7
Chemical Name
3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one
Synonyms
(2-alpha-Naphthoylethyl)dimethylamine;3-(diMethylaMino)-1-(naphthalen-1-yl)pr;2-(Dimethylamino)ethyl 1-naphthyl ketone;3-(Dimethylamino)-1-(1-naphthyl)-1-propanone;3-(dimethylamino)-1-(phthalen-5-yl)propan-1-one;3-(dimethylamino)-1-(1-naphthalenyl)-1-propanone;3-(dimethylamino)-1-(naphthalen-1-yl)propan-1-one;3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one;1-Propanone,3-(dimethylamino)-1-(1-naphthalenyl)-
CBNumber
CB2970905
Molecular Formula
C15H17NO
Formula Weight
227.3
MOL File
10320-49-7.mol
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3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one Property

Boiling point:
368.7±25.0 °C(Predicted)
Density 
1.072
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
8.78±0.28(Predicted)
Appearance
Colorless to light yellow Viscous liquid
InChI
InChI=1S/C15H17NO/c1-16(2)11-10-15(17)14-9-5-7-12-6-3-4-8-13(12)14/h3-9H,10-11H2,1-2H3
InChIKey
CXDXSNWZXJVDMC-UHFFFAOYSA-N
SMILES
C(C1=C2C(C=CC=C2)=CC=C1)(=O)CCN(C)C
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
M205300
Product name
3-(Dimethylamino)-1-(1-Naphthalenyl)-1-Propanone
Packaging
1g
Price
$525
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD153888
Product name
3-(Dimethylamino)-1-(naphthalen-5-yl)propan-1-one
Packaging
100mg
Price
$77
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD153888
Product name
3-(Dimethylamino)-1-(naphthalen-5-yl)propan-1-one
Packaging
250mg
Price
$152.5
Updated
2021/12/16
Matrix Scientific
Product number
073627
Product name
3-(Dimethylamino)-1-(naphthalen-5-yl)propan-1-one
Purity
95+%
Packaging
250mg
Price
$231
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD153888
Product name
3-(Dimethylamino)-1-(naphthalen-5-yl)propan-1-one
Packaging
500mg
Price
$265
Updated
2021/12/16
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3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one Chemical Properties,Usage,Production

Uses

3-(Dimethylamino)-1-(1-Naphthalenyl)-1-Propanone is a compound related to TMC207 which is used in the treatment of drug-resistant tuberculosis, and was studied for its anti-tubercular activity.

Synthesis

941-98-0

50-00-0

506-59-2

10320-49-7

1-Acetylnaphthalene (8 g, 0.047 mol), paraformaldehyde (2 g, 0.065 mol) and dimethylamine hydrochloride (5.3 g, 0.065 mol) were dissolved in ethanol (15 mL), followed by the addition of 0.6 mL of concentrated hydrochloric acid. The reaction mixture was heated to reflux for 12 hours, after which it was cooled to room temperature and refrigerated at -20 °C overnight. A white solid precipitated from the reaction mixture, which was separated by filtration and washed with ethanol. The resulting white solid was dissolved in water and 50% aqueous sodium carbonate solution (5.8 g, 0.54 mol) was slowly added. After stirring for 10-15 min, the aqueous phase was extracted with ethyl acetate (20 mL x 3), the organic layers were combined, washed sequentially with water (15 mL x 2) and saturated saline (15 mL x 2), and dried over anhydrous sodium sulfate. After filtration, the solvent was evaporated under reduced pressure to obtain the target compound 3-dimethylamino-1-(naphthalen-5-yl)acetone as a colorless oil (8 g, 70% yield).

References

[1] Chinese Chemical Letters, 2015, vol. 26, # 6, p. 790 - 792
[2] Patent: EP2371819, 2011, A1. Location in patent: Page/Page column 7
[3] Patent: EP2573067, 2013, A1. Location in patent: Paragraph 0065; 0066
[4] Patent: TW2016/4185, 2016, A. Location in patent: Paragraph 0342; 0343
[5] ACS Medicinal Chemistry Letters, 2017, vol. 8, # 10, p. 1019 - 1024

3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one manufacturers

Qingdao RENAS Polymer Material Co., Ltd.
Product
3-(dimethylamino)-1-(naphthalen-1-yl)propan-1-one 10320-49-7
Price
US $0.00/kg
Min. Order
20kg
Purity
99%
Supply Ability
20 tons
Release date
2025-04-26
Hebei Chuanghai Biotechnology Co., Ltd
Product
3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one 10320-49-7
Price
US $10.00/KG
Min. Order
100KG
Purity
99%
Supply Ability
100 mt
Release date
2024-11-22
Henan Aochuang Chemical Co.,Ltd.
Product
3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one 10320-49-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-30

10320-49-7, 3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-oneRelated Search:

3-(DIMETHYLAMINO)-1-(NAPHTHALEN-1-YL)PROPAN-1-ONE HYDROCHLORIDE (5R)-3-(4-BROMO-3-FLUOROPHENYL)-5-HYDROXYMETHYLOXAZOLIDIN-2-ONE CarbaMic acid, N-[3-fluoro-4-[6-(2-Methyl-2H-tetrazol-5-yl)-3-pyridinyl]phenyl]-, phenylMethyl ester 3-benzyl-6-bromo-2-methoxyquinoline 4-Bromo-2-nitroaniline 4-Pyrimidinamine, 2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]- 5-BROMO-2-(2-METHYL-2H-TETRAZOL-5-YL)-PYRIDINE 2,5-Dichloro-N-[2-[(1-methylethyl)thio]phenyl]-4-pyrimidinamine 3-benzyl-6-bromo-2-chloroquinoline 2-(2-Methyl-2H-tetrazol-5-yl)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine 5-Methyl-2-(1-Methylethoxy)-4- (4-piperidinyl)- BenzenaMine hydrochloride (1:2) 1-(1-OXO-2,3-DIHYDRO-1H-CYCLOPENTA-[A]NAPHTHALEN-3-YL)-AZEPAN-2-ONE ALPHA-NETA 1-(1-OXO-2,3-DIHYDRO-1H-CYCLOPENTA[A]-NAPHTHALEN-3-YL)-PYRROLIDIN-2-ONE 3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one

  • 1-Propanone,3-(dimethylamino)-1-(1-naphthalenyl)-
  • 3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one
  • 3-(dimethylamino)-1-(naphthalen-1-yl)propan-1-one
  • (2-alpha-Naphthoylethyl)dimethylamine
  • 2-(Dimethylamino)ethyl 1-naphthyl ketone
  • 3-(dimethylamino)-1-(phthalen-5-yl)propan-1-one
  • 3-(dimethylamino)-1-(1-naphthalenyl)-1-propanone
  • 3-(diMethylaMino)-1-(naphthalen-1-yl)pr
  • 3-(Dimethylamino)-1-(1-naphthyl)-1-propanone
  • 10320-49-7
  • bedaquiline intermediates