4-Pyrimidinamine, 2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]-

Product Name: 4-Pyrimidinamine, 2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]-
CAS No.: 761440-16-8
Chemical Name: 4-Pyrimidinamine, 2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]-
Synonyms: 2,5-dichloro-N-(2-(isopropylsulfonyl)phenyl)pyrimidin-4-amine;OROPYRIMIDIN-4-YL;Ceritinib Dichloro Impurity;-[(1-methylethyl)sulfonyl]phenyl;2,5-dichloro-N-(2-(isopropylsulfonyl)phenyl);2,5-dichloro-N-(2-propan-2-ylsulfonylphenyl)pyrimidin-4-amine;2,5-dichloro-N-[2-(propane-1-sulfonyl)phenyl]pyriMidin-4-aMine;2,5-dichloro-N-[2-(propane-2-sulfonyl)phenyl]pyrimidin-4-amine;4-Pyrimidinamine, 2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]p;2,5-Dichloro-N-[2-[(1-methyl)sulfonyl]phenyl]-4-pyrimidinamine
CBNumber: CB52473821
Molecular Formula: C13H13Cl2N3O2S
Formula Weight: 346.23
MOL File: 761440-16-8.mol

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4-Pyrimidinamine, 2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]- Property

Melting point:: 149.0 to 153.0 °C
Boiling point:: 538℃
Density: 1.436
Flash point:: 279℃
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: powder to crystal
pka: -0.03±0.10(Predicted)
color: White to Light yellow
InChI: InChI=1S/C13H13Cl2N3O2S/c1-8(2)21(19,20)11-6-4-3-5-10(11)17-12-9(14)7-16-13(15)18-12/h3-8H,1-2H3,(H,16,17,18)
InChIKey: WWVLDJAVSQZSKO-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=C(Cl)C(NC2=CC=CC=C2S(C(C)C)(=O)=O)=N1

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Safety

HS Code: 2933.59.8000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: D5068
Product name: 2,5-Dichloro-N-[2-(isopropylsulfonyl)phenyl]pyrimidin-4-amine
Purity: >97.0%(HPLC)(N)
Packaging: 200mg
Price: $73
Updated: 2025/07/31

TCI Chemical

Product number: D5068
Product name: 2,5-Dichloro-N-[2-(isopropylsulfonyl)phenyl]pyrimidin-4-amine
Purity: >97.0%(HPLC)(N)
Packaging: 1g
Price: $216
Updated: 2025/07/31

TRC

Product number: D434885
Product name: 2,5-Dichloro-N-[2-(isopropylsulfonyl)phenyl]pyrimidin-4-amine
Packaging: 1g
Price: $580
Updated: 2021/12/16

Matrix Scientific

Product number: 096607
Product name: 2,5-Dichloro-N-(2-(isopropylsulfonyl)-phenyl)pyrimidin-4-amine
Purity: 95+%
Packaging: 250mg
Price: $439
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0362853
Product name: 2,5-DICHLORO-N-(2-(ISOPROPYLSULFONYL)PHENYL)PYRIMIDIN-4-AMINE
Purity: 95.00%
Packaging: 5MG
Price: $495.5
Updated: 2021/12/16

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4-Pyrimidinamine, 2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]- Chemical Properties,Usage,Production

Uses

2,5-Dichloro-N-[2-(isopropylsulfonyl)phenyl]pyrimidin-4-amine is used as a reagent in the synthesis of potent and selective anaplastic lymphoma kinase (ALK-5) inhibitors, used as an anti-tumor treatment.

Synthesis

76697-50-2

5750-76-5

761440-16-8

To a flask containing 40 g (0.200 mol) 2-(isopropylsulfonyl)aniline (Formula-XI) in 400 mL of toluene solution under nitrogen protection were added 49.7 g (0.27 mol) 2,4,5-trichloropyrimidine (Formula-XII), 81.7 g (0.25 mol) cesium carbonate, 4.5 g (0.02 mol) palladium(II) acetate, and 13.1 g (0.05 mol) triphenylphosphine. The reaction mixture was heated to reflux under nitrogen atmosphere and maintained for 4 hours. The reaction was monitored by thin layer chromatography (TLC) to confirm that 2-(isopropylsulfonyl)aniline was completely consumed. Upon completion of the reaction, the mixture was cooled to 25-30 °C and filtered. The solids were washed with 400 mL of ethyl acetate. The filtrate and washings were combined and the crude product was obtained by removing toluene and ethyl acetate by distillation under reduced pressure at 60 °C. The crude product was purified by column chromatography to afford 45.6 g of 2,5-dichloro-N-(2-(isopropylsulfonyl)phenyl)pyrimidin-4-amine (formula-XIII) as a light yellow solid in 65.6% (theoretical) yield.

References

[1] European Journal of Medicinal Chemistry, 2017, vol. 136, p. 497 - 510
[2] Patent: WO2017/158619, 2017, A1. Location in patent: Page/Page column 19
[3] Patent: EP2990405, 2016, A1. Location in patent: Paragraph 0097; 0120; 0121
[4] Journal of Medicinal Chemistry, 2013, vol. 56, # 14, p. 5675 - 5690
[5] European Journal of Medicinal Chemistry, 2016, vol. 123, p. 80 - 89

4-Pyrimidinamine, 2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Pyrimidinamine, 2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]- Suppliers

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View Lastest Price from 4-Pyrimidinamine, 2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]- manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 2,5-Dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]-4-pyrimidinamine 761440-16-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

Nanjing Fred Technology Co., Ltd

Product: 2,5-Dichloro-N-(2-(isopropylsulfonyl)phenyl)pyrimidin-4-amine 761440-16-8
Price: US $0.00-0.00/kg
Min. Order: 0.1kg
Purity: 99%(HPLC)
Supply Ability: 2000kg/Year
Release date: 2023-12-14

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2,5-Dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]-4-pyrimidinamine 761440-16-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

761440-16-8, 4-Pyrimidinamine, 2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]-Related Search:

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2,5-Dichloro-<i>N</i>-[2-(isopropylsulfonyl)phenyl]pyrimidin-4-amine

2,5-dichloro-N-(2-(isopropyl sulfonyl)phenyl)-pyrimidine-4-amine

2,5-dichloro-N-[2-(propane-2-sulfonyl)phenyl]pyrimidin-4-amine

4-Pyrimidinamine, 2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]-

2,5-dichloro-N-(2-(isopropylsulfonyl)phenyl)pyrimidin-4-amine

2,5-dichloro-N-[2-(propane-1-sulfonyl)phenyl]pyriMidin-4-aMine

(2,5-Dichloropyrimidin-4-yl)[2-[(propan-2-yl)sulfonyl]phenyl]amine

2,5-Dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]-4-pyrimidinamine

(2,5-DichloropyriMidin-4-yl)[2-[(propan-2-yl)sulfonyl]phenyl]aMine 4-PyriMidinaMine, 2,5-dichloro-N-[2-[(1-Methylethyl)sulfonyl]phenyl]- (2,5-DichloropyriMidin-4-yl)[2-(propane-2-sulfonyl)phenyl]-aMine 2,5-Dichloro-N-[2-[(1-Methylethyl)sulfonyl]phenyl]

(2,5-Dichloro-pyriMidin-4-yl)-[2-(propane-2-sulfonyl)-phenyl]-aMine

2,5-Dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]-4-pyrimidinamine (2,5-Dichloropyrimidin-4-yl)[2-[(propan-2-yl)sulfonyl]phenyl]amine

4-Pyrimidimine, 2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]-

5-Dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]-4-pyrimidinamine

2,5-dichloro-N-(2-propan-2-ylsulfonylphenyl)pyrimidin-4-amine

4-Pyrimidinamine,2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]-2,5-Dichloro-N-[2-(isopropylsulfonyl)phenyl]pyrimidin-4-amine

2,5-Dichloro-N-(2-(Isopropylsulfonyl)Phenyl)Pyrimidin-4-Amine,>98%

OROPYRIMIDIN-4-YL

Ceritinib Dichloro Impurity

-[(1-methylethyl)sulfonyl]phenyl

2,5-dichloro-N-(2-(isopropylsulfonyl)phenyl)pyrimidin-4-amin...

TIANFU-CHEM - 4-Pyrimidinamine, 2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]-

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2,5-dichloro-N - [2- [(1-methylethyl) sulfonyl] phenyl] -4-pyrimidinamide

2,5-Dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]pyrimidin-4-ylamine

761440-16-8

417721-36-8

761440-16-8