3-benzyl-6-bromo-2-methoxyquinoline

Product Name: 3-benzyl-6-bromo-2-methoxyquinoline
CAS No.: 654655-69-3
Chemical Name: 3-benzyl-6-bromo-2-methoxyquinoline
Synonyms: Bedaquiline Impurity A;Bedaquiline Impurity 12;Bedaquiline Fumarate Impurity 22;6-Bromo-2-methoxy-3-benzylquinoline;3-benzyl-6-bromo-2-methoxyquinoline;3-BENZYL 1-6-BROMO-2-METHOXYQUINOLINE;3-Benzyl-6-bromo-2-methoxyouinoline(BBMQ;6-bromo-2-methoxy-3-(phenylmethyl)-Quinoline;Quinoline, 6-bromo-2-methoxy-3-(phenylmethyl)-;Bedaquiline int-2 3-Benzyl-6-bromo-2-methoxyquinoline
CBNumber: CB62522784
Molecular Formula: C17H14BrNO
Formula Weight: 328.2
MOL File: 654655-69-3.mol

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3-benzyl-6-bromo-2-methoxyquinoline Property

Melting point:: 82-83℃
Boiling point:: 420.5±40.0 °C(Predicted)
Density: 1.388±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 2.45±0.50(Predicted)
color: Off-White
InChI: InChI=1S/C17H14BrNO/c1-20-17-14(9-12-5-3-2-4-6-12)10-13-11-15(18)7-8-16(13)19-17/h2-8,10-11H,9H2,1H3
InChIKey: WMFHVNYOCKTDMX-UHFFFAOYSA-N
SMILES: N1C2C(=CC(Br)=CC=2)C=C(CC2=CC=CC=C2)C=1OC

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: B684850
Product name: 6-Bromo-2-methoxy-3-benzylquinoline
Packaging: 50mg
Price: $145
Updated: 2021/12/16

AK Scientific

Product number: X6911
Product name: 3-Benzyl-6-bromo-2-methoxyquinoline
Packaging: 100mg
Price: $30
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB43272
Product name: 3-Benzyl-6-bromo-2-methoxyquinoline
Packaging: 100mg
Price: $50
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB43272
Product name: 3-Benzyl-6-bromo-2-methoxyquinoline
Packaging: 250mg
Price: $90
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB43272
Product name: 3-Benzyl-6-bromo-2-methoxyquinoline
Packaging: 500mg
Price: $135
Updated: 2021/12/16

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3-benzyl-6-bromo-2-methoxyquinoline Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

3-benzyl-6-bromo-2-methoxyquinoline is a reactant used in the preparation of Bedaquiline (B119550), a potential drug in the treatment of tuberculosis.

Synthesis

654655-68-2

124-41-4

654655-69-3

3-Benzyl-6-bromo-2-chloroquinoline (20 g, 0.06 mol) was dissolved in anhydrous methanol (100 mL), followed by the addition of a methanolic solution of 15% sodium methanolate (108 g). The reaction mixture was refluxed overnight with stirring. Upon completion of the reaction, the mixture was cooled to room temperature and stored at -20 °C overnight to induce precipitation of the product. The crude product 3-benzyl-6-bromo-2-methoxyquinoline precipitated as white needle-like crystals. The solid product was separated by filtration, washed with water and dried in air to give 19 g (96% yield) of the target compound as a white solid.

References

[1] ChemMedChem, 2017, vol. 12, # 2, p. 106 - 119
[2] Tetrahedron, 2007, vol. 63, # 2, p. 451 - 460
[3] Chinese Chemical Letters, 2015, vol. 26, # 6, p. 790 - 792
[4] Patent: WO2005/70430, 2005, A1. Location in patent: Page/Page column 34-35
[5] Patent: WO2006/67048, 2006, A1. Location in patent: Page/Page column 27

3-benzyl-6-bromo-2-methoxyquinoline Preparation Products And Raw materials

Raw materials

Preparation Products

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3-benzyl-6-bromo-2-methoxyquinoline Suppliers

Canada 1 China 242 India 13 Ukraine 1 United Kingdom 1 United States 9 Global 267

Yancheng ZhengChi biological and Technology Co, Ltd.

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View Lastest Price from 3-benzyl-6-bromo-2-methoxyquinoline manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 3-benzyl-6-bromo-2-methoxyquinoline 654655-69-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

airuikechemical co., ltd.

Product: Quinoline, 6-bromo-2-methoxy-3-(phenylmethyl)- 654655-69-3
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 99.99%
Supply Ability: 20 tons
Release date: 2024-04-07

Weijer International Trade (Hebei) Co., Ltd

Product: 3-Benzyl-6-bromo-2-methoxyquinoline 654655-69-3
Price: US $30.00/KG
Min. Order: 1KG
Purity: >99%
Supply Ability: 20tons
Release date: 2023-03-08

654655-69-3, 3-benzyl-6-bromo-2-methoxyquinolineRelated Search:

Ethyl isonicotinate Bedaquiline fumarate Bedaquiline Impurity 4 Quinoline, 2-methoxy-3-(phenylmethyl)- Benzenepropanamide, N-(2-bromophenyl)- Peroxyacetic acid Formic acid 3-(DIMETHYLAMINO)-1-(NAPHTHALEN-1-YL)PROPAN-1-ONE HYDROCHLORIDE (5R)-3-(4-BROMO-3-FLUOROPHENYL)-5-HYDROXYMETHYLOXAZOLIDIN-2-ONE CarbaMic acid, N-[3-fluoro-4-[6-(2-Methyl-2H-tetrazol-5-yl)-3-pyridinyl]phenyl]-, phenylMethyl ester 4-Bromo-2-nitroaniline 4-Pyrimidinamine, 2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]- 5-BROMO-2-(2-METHYL-2H-TETRAZOL-5-YL)-PYRIDINE 2,5-Dichloro-N-[2-[(1-methylethyl)thio]phenyl]-4-pyrimidinamine 3-benzyl-6-bromo-2-chloroquinoline 3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one 2-(2-Methyl-2H-tetrazol-5-yl)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine 5-Methyl-2-(1-Methylethoxy)-4- (4-piperidinyl)- BenzenaMine hydrochloride (1:2)

3-benzyl-6-bromo-2-methoxyquinoline

6-Bromo-2-methoxy-3-benzylquinoline

6-bromo-2-methoxy-3-(phenylmethyl)-Quinoline

Bedaquiline int-2 3-Benzyl-6-bromo-2-methoxyquinoline

Quinoline, 6-bromo-2-methoxy-3-(phenylmethyl)-

Bedaquiline Impurity A

3-BENZYL 1-6-BROMO-2-METHOXYQUINOLINE

Bedaquiline Impurity 12

Bedaquiline Fumarate Impurity 22

3-benzyl-6-bromo-2-methoxyquinolineQ: What is 3-benzyl-6-bromo-2-methoxyquinoline Q: What is the CAS Number of 3-benzyl-6-bromo-2-methoxyquinoline Q: What is the storage condition of 3-benzyl-6-bromo-2-methoxyquinoline Q: What are the applications of 3-benzyl-6-bromo-2-methoxyquinoline

3-Benzyl-6-bromo-2-methoxyouinoline(BBMQ

654655-69-3

bedaquiline intermediates