LDK-378 dihydrochloride

Product Name: LDK-378 dihydrochloride
CAS No.: 1380575-43-8
Chemical Name: LDK-378 dihydrochloride
Synonyms: LDK378 2Hcl;5-Chloro-N4-[;Ceritinib 2hcl;Ceritinib diHCl;Ceritinib intermediate;Ceritinib Hydrochloride;LDK 378 dihydrochloride;LDK-378 dihydrochloride;LDK378 2HCl (Ceritinib);LDK378 (dihydrochloride)
CBNumber: CB72666649
Molecular Formula: C28H37Cl2N5O3S
Formula Weight: 594.6
MOL File: 1380575-43-8.mol

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LDK-378 dihydrochloride Property

storage temp.: Store at -20°C
solubility: ≥12.38 mg/mL in EtOH with ultrasonic; ≥13.7 mg/mL in H2O; ≥29.65 mg/mL in DMSO
form: Powder
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-1407
Product name: Ceritinibdihydrochloride
Purity: 99.83%
Packaging: 5mg
Price: $50
Updated: 2021/12/16

ChemScene

Product number: CS-1407
Product name: Ceritinibdihydrochloride
Purity: 99.83%
Packaging: 10mg
Price: $70
Updated: 2021/12/16

ChemScene

Product number: CS-1407
Product name: Ceritinibdihydrochloride
Purity: 99.83%
Packaging: 50mg
Price: $100
Updated: 2021/12/16

ApexBio Technology

Product number: A3544
Product name: LDK378dihydrochloride
Packaging: 5mg
Price: $103
Updated: 2021/12/16

ChemScene

Product number: CS-1407
Product name: Ceritinibdihydrochloride
Purity: 99.83%
Packaging: 100mg
Price: $150
Updated: 2021/12/16

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LDK-378 dihydrochloride Chemical Properties,Usage,Production

Biological Activity

ldk378 is a highly potent inhibitor of anaplastic lymphoma kinase (alk), which is a receptor tyrosine kinase belonging to the superfamily of insulin receptor, with half maximal inhibitory concentration ic50 of 200 pm. ldk378 also exhibits modest to high inhibition against a panel of other kinases, in which only three kinases with ic50 below 100 nm includes igf-1r (8 nm), insr (7 nm) and stk22d (23 nm). in previous studies, ldk378 has been found to inhibit the proliferation of ba/f3 cells transfected with the npm-alk fusion gene and karpas 299 human non-hodgkin’s ki-positivr large cell lymphoma harboring the npm-alk fusion gene with ic50 of 22.8 nm and 26 nm.

References

[1]chen j, jiang c, wang s. ldk378: a promising anaplastic lymphoma kinase (alk) inhibitor. j med chem. 2013 jul 25;56(14):5673-4. doi: 10.1021/jm401005u. epub 2013 jul 9.
[2]marsilje th, pei w, chen b, lu w, uno t, jin y, jiang t, kim s, li n, warmuth m, sarkisova y, sun f, steffy a, pferdekamper ac, li ag, joseph sb, kim y, liu b, tuntland t, cui x, gray ns, steensma r, wan y, jiang j, chopiuk g, li j, gordon wp, richmond w, johnson k, chang j, groessl t, he yq, phimister a, aycinena a, lee cc, bursulaya b, karanewsky ds, seidel hm, harris jl, michellys py. synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (alk) inhibitor 5-chloro-n2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-n4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (ldk378) currently in phase 1 and phase 2

LDK-378 dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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LDK-378 dihydrochloride Suppliers

China 88 India 1 United States 9 Global 98

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42958
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Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: meilunui@163.com
Country: China
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Advantage: 58

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
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Alputon Inc.

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Fax: 021-60753309
Country: China
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MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
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AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
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DONGSHENG CHIRAL PHARMA

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Nanjing First Pharmaceutical Co., Ltd.

Tel: 025-83172655 13585105703
Fax: +86-25-86501191
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Country: China
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Suzhou yacoo science co.,Ltd

Tel: 0512-87182056 18013166090
Fax: 0512-87182056
Email: lingling.qi@yacoo.com.cn
Country: China
ProdList: 7295
Advantage: 60

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2990
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View Lastest Price from LDK-378 dihydrochloride manufacturers

Nanjing Fred Technology Co., Ltd

Product: Ceritinib dihydrochloride 1380575-43-8
Price: US $0.00-0.00/kg
Min. Order: 0.1kg
Purity: 99.5%(HPLC); Each single impurity<0.1%
Supply Ability: 1500kg/Year
Release date: 2023-12-14

Beijing Yibai Biotechnology Co., Ltd

Product: Ceritinib dihydrochloride 1380575-43-8
Price: US $0.00-0.00/KG
Min. Order: 1g
Purity: 99.0%
Supply Ability: 500kg/month
Release date: 2019-08-27

Career Henan Chemical Co

Product: LDK-378 dihydrochloride 1380575-43-8
Price: US $100.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2018-07-30

1380575-43-8, LDK-378 dihydrochlorideRelated Search:

5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine Sunitinib Ibrutinib tert-butyl 4-(4-aMino-5-isopropoxy-2-Methylphenyl)piperidine-1-carboxylate 4-(5-isopropoxy-2-Methyl-4-nitrophenyl)pyridine Ceritinib (LDK378) 1-Chloro-5-isopropoxy-2-methyl-4-nitrobenzene 4-Pyrimidinamine, 2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]- 1-broMo-5-fluoro-2-Methyl-4-nitrobenzene 1-AMINO-2-(ISOPROPYLSULPHONYL)BENZENE 2,4,5-Trichloropyrimidine 1-BroMo-5-isopropoxy-2-Methyl-4-nitrobenzene 5-Methyl-2-(1-Methylethoxy)-4- (4-piperidinyl)- BenzenaMine hydrochloride (1:2)

LDK378 (Ceritinib) dihydrochloride

LDK 378 dihydrochloride

LDK378 (dihydrochloride)

LDK-378 dihydrochloride

LDK378 2Hcl

Ceritinib dihydrochloride

5-chloro-N2-(2-isopropoxy-5-Methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyriMidine-2,4-diaMine hydrochloride

LDK378 dihydrochloride, Ceritinib dihydrochloride

Ceritinib Hydrochloride

Ceritinib intermediate

5-Chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[5-methyl-2-(1-methylethoxy)-4-(4-piperidinyl)phenyl]-2,4-pyrimidinediamine hydrochloride (1:2)

LDK378 2HCl (Ceritinib)

5-Chloro-N4-[

LDK 378 DIHYDROCHLORIDE; LDK-378 DIHYDROCHLORIDE; CERITINIB DIHYDROCHLORIDE

CERITINIB DIHYDROCHLORIDE (LDK378 DIHYDROCHLORIDE)

5-CHLORO-N2-(2-ISOPROPOXY-5-METHYL-4-(PIPERIDIN-4-YL)PHENYL)-N4-(2-(ISOPROPYLSULFONYL)PHENYL)PYRIMIDINE-2,4-DIAMINE DIHYDROCHLORIDE

Ceritinib 2hcl

5-chloro-2-N-(5-methyl-4-piperidin-4-yl-2-propan-2-yloxyphenyl)-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine,dihydrochloride

Ceritinib diHCl

1380575-43-8

C28H38Cl3N5O3S

C28H36ClN5O3S2HCl

C28H36ClN5O3S2ClH