ChemicalBook > CAS DataBase List > LDK-378 dihydrochloride

LDK-378 dihydrochloride

Product Name
LDK-378 dihydrochloride
CAS No.
1380575-43-8
Chemical Name
LDK-378 dihydrochloride
Synonyms
LDK378 2Hcl;5-Chloro-N4-[;Ceritinib 2hcl;Ceritinib diHCl;Ceritinib intermediate;Ceritinib Hydrochloride;LDK 378 dihydrochloride;LDK-378 dihydrochloride;LDK378 2HCl (Ceritinib);LDK378 (dihydrochloride)
CBNumber
CB72666649
Molecular Formula
C28H37Cl2N5O3S
Formula Weight
594.6
MOL File
1380575-43-8.mol
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LDK-378 dihydrochloride Property

storage temp. 
Store at -20°C
solubility 
≥12.38 mg/mL in EtOH with ultrasonic; ≥13.7 mg/mL in H2O; ≥29.65 mg/mL in DMSO
form 
Powder
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-1407
Product name
Ceritinibdihydrochloride
Purity
99.83%
Packaging
5mg
Price
$50
Updated
2021/12/16
ChemScene
Product number
CS-1407
Product name
Ceritinibdihydrochloride
Purity
99.83%
Packaging
10mg
Price
$70
Updated
2021/12/16
ChemScene
Product number
CS-1407
Product name
Ceritinibdihydrochloride
Purity
99.83%
Packaging
50mg
Price
$100
Updated
2021/12/16
ApexBio Technology
Product number
A3544
Product name
LDK378dihydrochloride
Packaging
5mg
Price
$103
Updated
2021/12/16
ChemScene
Product number
CS-1407
Product name
Ceritinibdihydrochloride
Purity
99.83%
Packaging
100mg
Price
$150
Updated
2021/12/16
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LDK-378 dihydrochloride Chemical Properties,Usage,Production

Biological Activity

ldk378 is a highly potent inhibitor of anaplastic lymphoma kinase (alk), which is a receptor tyrosine kinase belonging to the superfamily of insulin receptor, with half maximal inhibitory concentration ic50 of 200 pm. ldk378 also exhibits modest to high inhibition against a panel of other kinases, in which only three kinases with ic50 below 100 nm includes igf-1r (8 nm), insr (7 nm) and stk22d (23 nm). in previous studies, ldk378 has been found to inhibit the proliferation of ba/f3 cells transfected with the npm-alk fusion gene and karpas 299 human non-hodgkin’s ki-positivr large cell lymphoma harboring the npm-alk fusion gene with ic50 of 22.8 nm and 26 nm.

References

[1]chen j, jiang c, wang s. ldk378: a promising anaplastic lymphoma kinase (alk) inhibitor. j med chem. 2013 jul 25;56(14):5673-4. doi: 10.1021/jm401005u. epub 2013 jul 9.
[2]marsilje th, pei w, chen b, lu w, uno t, jin y, jiang t, kim s, li n, warmuth m, sarkisova y, sun f, steffy a, pferdekamper ac, li ag, joseph sb, kim y, liu b, tuntland t, cui x, gray ns, steensma r, wan y, jiang j, chopiuk g, li j, gordon wp, richmond w, johnson k, chang j, groessl t, he yq, phimister a, aycinena a, lee cc, bursulaya b, karanewsky ds, seidel hm, harris jl, michellys py. synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (alk) inhibitor 5-chloro-n2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-n4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (ldk378) currently in phase 1 and phase 2

LDK-378 dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from LDK-378 dihydrochloride manufacturers

Nanjing Fred Technology Co., Ltd
Product
Ceritinib dihydrochloride 1380575-43-8
Price
US $0.00-0.00/kg
Min. Order
0.1kg
Purity
99.5%(HPLC); Each single impurity<0.1%
Supply Ability
1500kg/Year
Release date
2023-12-14
Beijing Yibai Biotechnology Co., Ltd
Product
Ceritinib dihydrochloride 1380575-43-8
Price
US $0.00-0.00/KG
Min. Order
1g
Purity
99.0%
Supply Ability
500kg/month
Release date
2019-08-27
Career Henan Chemical Co
Product
LDK-378 dihydrochloride 1380575-43-8
Price
US $100.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2018-07-30

1380575-43-8, LDK-378 dihydrochlorideRelated Search:

5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine Sunitinib Ibrutinib tert-butyl 4-(4-aMino-5-isopropoxy-2-Methylphenyl)piperidine-1-carboxylate 4-(5-isopropoxy-2-Methyl-4-nitrophenyl)pyridine Ceritinib (LDK378) 1-Chloro-5-isopropoxy-2-methyl-4-nitrobenzene 4-Pyrimidinamine, 2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]- 1-broMo-5-fluoro-2-Methyl-4-nitrobenzene 1-AMINO-2-(ISOPROPYLSULPHONYL)BENZENE 2,4,5-Trichloropyrimidine 1-BroMo-5-isopropoxy-2-Methyl-4-nitrobenzene 5-Methyl-2-(1-Methylethoxy)-4- (4-piperidinyl)- BenzenaMine hydrochloride (1:2)

  • LDK378 (Ceritinib) dihydrochloride
  • LDK 378 dihydrochloride
  • LDK378 (dihydrochloride)
  • LDK-378 dihydrochloride
  • LDK378 2Hcl
  • Ceritinib dihydrochloride
  • 5-chloro-N2-(2-isopropoxy-5-Methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyriMidine-2,4-diaMine hydrochloride
  • LDK378 dihydrochloride, Ceritinib dihydrochloride
  • Ceritinib Hydrochloride
  • Ceritinib intermediate
  • 5-Chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[5-methyl-2-(1-methylethoxy)-4-(4-piperidinyl)phenyl]-2,4-pyrimidinediamine hydrochloride (1:2)
  • LDK378 2HCl (Ceritinib)
  • 5-Chloro-N4-[
  • LDK 378 DIHYDROCHLORIDE; LDK-378 DIHYDROCHLORIDE; CERITINIB DIHYDROCHLORIDE
  • CERITINIB DIHYDROCHLORIDE (LDK378 DIHYDROCHLORIDE)
  • 5-CHLORO-N2-(2-ISOPROPOXY-5-METHYL-4-(PIPERIDIN-4-YL)PHENYL)-N4-(2-(ISOPROPYLSULFONYL)PHENYL)PYRIMIDINE-2,4-DIAMINE DIHYDROCHLORIDE
  • Ceritinib 2hcl
  • 5-chloro-2-N-(5-methyl-4-piperidin-4-yl-2-propan-2-yloxyphenyl)-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine,dihydrochloride
  • Ceritinib diHCl
  • 1380575-43-8
  • C28H38Cl3N5O3S
  • C28H36ClN5O3S2HCl
  • C28H36ClN5O3S2ClH