6-Methyl-4-phenylchroman-2-one
- Product Name
- 6-Methyl-4-phenylchroman-2-one
- CAS No.
- 40546-94-9
- Chemical Name
- 6-Methyl-4-phenylchroman-2-one
- Synonyms
- LACTONE IMPURITY;Tolterodine impurity Z09;forTolterodine-L-tartrate;Tolterodine interMediates;Tolterodine Lactone IMpurity;6-METHYL-4-PHENYL-CHROMAN-ONE;6-Methyl-4-phenyl-2-chromanone;6-METHYL-4-PHENYLCHROMAN-2-ONE;6-Methy1-4-phenyl-chroMan-2-one;6-Methyl-4-phenyl-2-chromanone>
- CBNumber
- CB9120255
- Molecular Formula
- C16H14O2
- Formula Weight
- 238.28
- MOL File
- 40546-94-9.mol
6-Methyl-4-phenylchroman-2-one Property
- Melting point:
- 68-70°C
- Boiling point:
- 230°C/16mmHg(lit.)
- Density
- 1.166±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- White to Off-White
- CAS DataBase Reference
- 40546-94-9(CAS DataBase Reference)
Safety
- HS Code
- 2932.20.4500
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P363Wash contaminated clothing before reuse.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 1A01060
- Product name
- 6-Methyl-4-Phenylchromanone
- Purity
- Pharmaceutical Analytical Impurity (PAI)
- Packaging
- 25mg
- Price
- $646
- Updated
- 2025/07/31
- Product number
- M2093
- Product name
- 6-Methyl-4-phenyl-2-chromanone
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $29
- Updated
- 2025/07/31
- Product number
- M2093
- Product name
- 6-Methyl-4-phenyl-2-chromanone
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $115
- Updated
- 2025/07/31
- Product number
- M326450
- Product name
- rac-6-Methyl-4-phenylchroman-2-one
- Packaging
- 5g
- Price
- $180
- Updated
- 2021/12/16
- Product number
- M326450
- Product name
- rac-6-Methyl-4-phenylchroman-2-one
- Packaging
- 50mg
- Price
- $50
- Updated
- 2021/12/16
6-Methyl-4-phenylchroman-2-one Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
Intermediate in the production of Tolterodine.
Synthesis
106-44-5
621-82-9
40546-94-9
The general procedure for the synthesis of 6-methyl-4-phenylbenzodihydropyran-2-one from p-cresol and trans-cinnamic acid is as follows: a mixture of 0.5 kg cinnamic acid, 0.401 kg p-cresol and 2.2 L xylene was stirred for 15 minutes. 0.132 kg of concentrated sulfuric acid was slowly added under continuous stirring. After addition of the acid, the reaction mixture was stirred at 140-145 °C for the reaction. After completion of the reaction, the reaction was cooled to room temperature and then washed with 1.0 L of deionized water. The reaction mixture was further cooled to 10-15 °C, and 0.5 N NaOH solution was added to deionized water, and the reaction mixture was added dropwise and stirred at the same temperature for 1 hour. The organic layer was separated and washed with deionized water. The organic layer was completely distilled under reduced pressure (30-40 mmHg) to give 3,4-dihydro-6-methyl-4-phenyl-2H-benzopyran-2-one (Yield: 0.78 kg, Yield: 97%).HPLC purity: > 95%.
References
[1] Patent: WO2010/46801, 2010, A2. Location in patent: Page/Page column 15
[2] Research on Chemical Intermediates, 2016, vol. 42, # 7, p. 6407 - 6422
[3] Organic Process Research and Development, 2005, vol. 9, # 3, p. 314 - 318
[4] Tetrahedron Letters, 2012, vol. 53, # 33, p. 4469 - 4472
[5] Tetrahedron, 2014, vol. 70, # 34, p. 5221 - 5233
6-Methyl-4-phenylchroman-2-one Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Methyl-4-phenylchroman-2-one manufacturers
- Product
- 6-Methyl-4-phenylchroman-2-one 40546-94-9
- Price
- US $5.00-2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-08-14
- Product
- 6-Methyl-4-phenylchroman-2-one 40546-94-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-24