methoctramine tetrahydrochloride hemihydrate
- Product Name
- methoctramine tetrahydrochloride hemihydrate
- CAS No.
- 104807-46-7
- Chemical Name
- methoctramine tetrahydrochloride hemihydrate
- Synonyms
- methoctramine;MethoctraMine hydrate;methoctramine hemihydrate;Methoctramine tetrahydrochloride hydrate;methoctramine tetrahydrochloride hemihydrate;N,N′-bis[6-[[(2-Methoxyphenyl)methyl]amino]hexyl]-1,8-octane diamine tetrahydrochloride hydrate;Methoctramine hemihydrate tetrahydrochloride, N,Nμ-bis[6-[[(2-Methoxyphenyl)methyl]amino]hexyl]-1,8-octane diamine hemihydrate tetrahydrochloride
- CBNumber
- CB91216157
- Molecular Formula
- 2C36H62N4O2.4ClH.H2O
- Formula Weight
- 1329.68
- MOL File
- 104807-46-7.mol
methoctramine tetrahydrochloride hemihydrate Property
- storage temp.
- 2-8°C
- solubility
- H2O: >20mg/mL
- form
- solid
- color
- white
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- M105
- Product name
- Methoctramine hydrate
- Purity
- ≥97% (NMR), solid
- Packaging
- 10mg
- Price
- $223
- Updated
- 2024/03/01
- Product number
- M105
- Product name
- Methoctramine hydrate
- Purity
- ≥97% (NMR), solid
- Packaging
- 25mg
- Price
- $444
- Updated
- 2024/03/01
- Product number
- 24317
- Product name
- Methoctramine
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- 24317
- Product name
- Methoctramine
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $208
- Updated
- 2024/03/01
- Product number
- M105
- Product name
- Methoctramine hydrate
- Purity
- ≥97% (NMR), solid
- Packaging
- 100mg
- Price
- $1510
- Updated
- 2024/03/01
methoctramine tetrahydrochloride hemihydrate Chemical Properties,Usage,Production
Uses
Methoctramine is a muscarinic M2 receptor antagonist.
Uses
Methoctramine hydrate has been used:
- As a muscarinic receptor 2 antogonist.
- As a test molecule to check its effect on premature osteogenic differentiation of HGPS (Hutchinson-Gilford progeria syndrome) iPS (induced pluripotent)-derived mesenchymal stem cells.
Definition
ChEBI: A hydrochloride obtained by combining methoctramine with four molar equivalents of hydrochloric acid.
General Description
Methoctramine (N, N′-bis [6-[[(2-methoxyphenyl)-methyl] hexyl]-1, 8-octane] diamine) is a derivative of polymethylene tetramine.
Biochem/physiol Actions
Methoctramine is a selective M2 muscarinic receptor antagonist at nM concentrations. At mM concentrations, methoctramine directly inhibits the high affinity GTPase activity of G proteins. In oesophageal muscle, acetylcholine-mediated increase in calcium and arachidonic acid release were reduced by the M2 receptor antagonist, methoctramine. Methoctramine infused bilaterally in the dorsolateral striatum, considerably enhanced memory in cognitively impaired aged rats. Methoctramine plays a vital role in muscarinic receptor classification.
methoctramine tetrahydrochloride hemihydrate Preparation Products And Raw materials
Raw materials
Preparation Products
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