3,5-difluorobenzophenone
- Product Name
- 3,5-difluorobenzophenone
- CAS No.
- 179113-89-4
- Chemical Name
- 3,5-difluorobenzophenone
- Synonyms
- 3,5-DIFLUOROBENZOPHENONE;3,5-Difluorobenzophenone97%;3,5-Difluorobenzophenone 97%;3,5-DIFLUOROBENZOPHENONE, 98+%;(3,5-Difluorophenyl)(phenyl)methanone;Methanone, (3,5-difluorophenyl)phenyl-
- CBNumber
- CB9122835
- Molecular Formula
- C13H8F2O
- Formula Weight
- 218.2
- MOL File
- 179113-89-4.mol
3,5-difluorobenzophenone Property
- Melting point:
- 57-59°C
- Boiling point:
- 117°C 5mm
- Density
- 1.239±0.06 g/cm3(Predicted)
- Flash point:
- 116-118°C/5mm
- storage temp.
- 2-8°C
- form
- crystalline solid
- color
- Yellow
- BRN
- 7919206
- CAS DataBase Reference
- 179113-89-4(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B20554
- Product name
- 3,5-Difluorobenzophenone, 98+%
- Packaging
- 1g
- Price
- $21.9
- Updated
- 2021/12/16
- Product number
- B20554
- Product name
- 3,5-Difluorobenzophenone, 98+%
- Packaging
- 5g
- Price
- $83.1
- Updated
- 2021/12/16
- Product number
- D445443
- Product name
- 3,5-Difluorobenzophenone
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 2617-3-80
- Product name
- 3,5-Difluorobenzophenone
- Purity
- 97%
- Packaging
- 25g
- Price
- $77
- Updated
- 2021/12/16
- Product number
- 005211
- Product name
- 3,5-Difluorobenzophenone
- Purity
- 97%
- Packaging
- 1g
- Price
- $14
- Updated
- 2021/12/16
3,5-difluorobenzophenone Chemical Properties,Usage,Production
Preparation
Synthesis of 3,5-Difluorobenzophenone: Prior to acylations, 3,5-difluorobenzoic acid was reacted with freshly distilled thionyl chloride and catalytic amounts of DMF(2 drops). After two hours at 55 °C, the excess thionyl chloride was distilled between 75 and 77 °C. The acid halide was then fractionally distilled at 174 °C, and recovery was generally around 75%. To a 50 mL round bottom flask, equipped with a gas inlet, addition funnel, condenser, and drying tube, were added 3.01 g (22.6 mmol) of AlCl3. A mixture of 3.62 g (20.5 mmol) 3,5-difluorobenzoyl chloride and 8.01 g (102.5 mmol) benzene was added dropwise to the AlCl3. The reaction mixture was stirred for 4 hours, before heating to 75 °C. After 16 hours the reaction mixture was quenched by pouring into acidic ice water, followed by addition of 300 mL of chloroform, and transferring to a separatory funnel. The layers were separated and the organic layer was washed with 5 wt. % bicarbonate, distilled water, and then dried with MgSO4 and the solvents were removed, via rotary evaporation, leaving an off-white solid. The crude material was recrystallized from aqueous ethanol to afford (3.00 g, 67 %) of a crystalline white solid with a m.p. 58-59 °C (lit.21 m.p. 57-58 °C); 1H NMR (300 MHz, CDCl3, δ) 7.04 (tt, 1H, J = 8.4, 2.4 Hz), 7.31 (m, 2H), 7.51 (m, 2H), 7.63 (tt, 1H, J = 7.5, 1.2 Hz), 7.78 (m, 2H)
3,5-difluorobenzophenone Preparation Products And Raw materials
Raw materials
Preparation Products
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