Halofuginone hydrobromide

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Halofuginone hydrobromide

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Product Name: Halofuginone hydrobromide
CAS No.: 64924-67-0
Chemical Name: Halofuginone hydrobromide
Synonyms: STENOROL;Ru-19110;Tempostatin;RU-19110(HBr);Unii-ptc2969mv1;55837-20-2 (free);RU-19110 (hydrobromide);HALOFUGINONEHYDROBROMIDE;Haloperidone hydrobromide;Trans-halofuginone hydrobromide
CBNumber: CB91230111
Molecular Formula: C16H17BrClN3O3.HBr
Formula Weight: 495.59
MOL File: 64924-67-0.mol

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Halofuginone hydrobromide Property

Melting point:: 247° (dec)
storage temp.: Store at -20°C
solubility: Soluble to 100 mM in DMSO.

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Safety

Hazard Codes: Xn
Risk Statements: 22
RIDADR: UN2811 - class 6.1 - PG 1 - EHS - Toxic solids, organic, n.o.s., HI: all
WGK Germany: 3
RTECS: VA2397066

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P262Do not get in eyes, on skin, or on clothing.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 32481
Product name: Halofuginone hydrobromide
Purity: VETRANAL?, analytical standard
Packaging: 10mg
Price: $513
Updated: 2024/03/01

Tocris

Product number: 1993
Product name: Halofuginone hydrobromide
Purity: ≥98%(HPLC)
Packaging: 50
Price: $128
Updated: 2021/12/16

TRC

Product number: H102490
Product name: Halofuginone hydrobromide
Packaging: 1mg
Price: $155
Updated: 2021/12/16

TRC

Product number: H102490
Product name: Halofuginone hydrobromide
Packaging: 2mg
Price: $180
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FH23731
Product name: Halofuginone hydrobromide
Packaging: 500mg
Price: $200
Updated: 2021/12/16

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Halofuginone hydrobromide Chemical Properties,Usage,Production

regulation

Halofuginone hydrobromide is included in the European Union Register of Feed Additives pursuant to Regulation (EC) No 1831/2003 and is authorized for use in chickens for fattening and turkeys (maximum age 12 weeks) at a dose range of 2–3 mg/kg complete feedingstuffs with a withdrawal time of 5 days[1]. The European Food Safety Authority (EFSA) issued an opinion on the coccidiostat STENOROL® containing 0.6% halofuginone hydrobromide for chickens for fattening and turkeys (EFSA, 2003).

Description

Halofuginone hydrobromide (Halofuginone) is a specific collagen Type I inhibitor that antagonize or inhibit the development of new blood vessels, hence can prevent intimal hyperplasia at a vascular anastomosis. It is used in the treatment or prevention of coccidiosis in both humans and animals.

Chemical Properties

White to Off-White Solid

Uses

Halogenated derivative of Febrifugine. Halofuginone hydrobromide is used as an antiprotozoal (coccidiostat).

Definition

The hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibro-proliferative diseases.

Biological Activity

Halofuginone hydrobromide is a high affinity competitive prolyl-tRNA synthetase inhibitor (Ki = 18.3 nM). Blocks expression of MMP2. Inhibits ECM invasion in vitro and lung metastasis by bladder cancer cells in mice. Inhibits the development of Th17-driven autoimmunity in a mouse model of multiple sclerosis by activating the amino acid response (AAR) pathway. Also antiparasitic.

Toxicology

Halofuginone HBr (Halofuginone hydrobromide) is toxic by inhalation, dermal and ocular routes and is very irritant to both the eye and the skin. It is considered also a skin sensitiser[1].

storage

Store at -20°C

Mode of action

Halofuginone is an an ATP-dependent inhibitor prolyl-tRNA synthetase (Ki of 18.3 nM). Halofuginone attenuates osteoarthritis (OA) by inhibition of TGF-β activity. Blocks expression of MMP2 and inhibits ECM invasion in vitro and lung metastasis by bladder cancer cells in mice. Also inhibits the development of Th17-driven autoimmunity in a mouse model of multiple sclerosis by activating the amino acid response (AAR) pathway.

References

[1] Vasileios Bampidis, Giovanna Azimonti, Maria de Lourdes Bastos, et al. “Safety of a feed additive consisting of halofuginone hydrobromide (STENOROL?) for chickens for fattening and turkeys (Huvepharma N.V.).” EFSA Journal 20 12 (2022).

Halofuginone hydrobromide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Halofuginone hydrobromide manufacturers

Enki Biopharmaceuticals (Shanghai) Limited

Product: Halofuginone hydrobromide 64924-67-0
Price: US $10.00/kg
Min. Order: 25kg
Purity: 99%
Supply Ability: 10000kg /year
Release date: 2023-11-01

Zhuozhou Wenxi import and Export Co., Ltd

Product: Halofuginone Hydrobromide 64924-67-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Halofuginone Hydrobromide 64924-67-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

64924-67-0, Halofuginone hydrobromideRelated Search:

Dextromethorphan hydrobromide monohydrate Chlorobromoisocyanurate 4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate Citalopram hydrobromide Trazodone Pyridine hydrobromide Hydroxyacetone Halofuginone 1,3-Dihydroxyacetone Galantamine Hydrobromide 1-Bromo-3-chloro-5,5-dimethylhydantoin 3'-Hydroxypropiophenone Hydrogen bromide Cloperastine hydrochloride HYOSCINE N BUTYL BROMIDE BP Pipecuronium bromide Scopolamine hydrobromide Difluorochloromethane

Ru-19110

Tempostatin

Unii-ptc2969mv1

rel-7-BroMo-6-chloro-3-[3-[(2R,3S)-3-hydroxy-2-piperidinyl]-2-oxopropyl]-4(3H)-quinazolinone HydrobroMide

trans-(+/-)-7-BroMo-6-chloro-3-[3-(3-hydroxy-2- piperidinyl)-2-oxopropyl]-4(3H)-quinazolinone MonohydrobroMide

7-BroMo-6-chloro-3-(3-((2S,3R)-3-hydroxypiperidin-2-yl)-2-oxopropyl)quinazolin-4(3H)-one hydrobroMide

HALOFUGINONEHYDROBROMIDE

STENOROL

7-Bromo-6-chloro-3-[3-[(2S,3R)-3-hydroxypiperidin-2-yl]-2-oxopropyl]quinazolin-4-one hydrobromide

4(3H)-Quinazolinone,7-bromo-6-chloro-3-[3-[(2R,3S)-3-hydroxy-2-piperidinyl]-2-oxopropyl]-,hydrobromide (1:1), rel-

(+/-)-trans-7-Bromo-6-chloro-3-(3-(3-hydroxy-2-piperidyl)-acetonyl)-4(3H)-quinazolinone monohydrobromide

4(3H)-Quinazolinone, 7-bromo-6-chloro-3-(3-(2R,3S)-3-hydroxy-2-piperidinyl)-2-oxopropyl)-, monohydrobromide, rel-

4(3H)-Quinazolinone, 7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidinyl)-2-oxopropyl)-, hydrobromide, trans-(+-)-

4(3H)-Quinazolinone, 7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidinyl)-2-oxopropyl)-, hydrobromide, trans-(+/-)-

Trans-halofuginone hydrobromide

HALOFUGINONE HBR ((2R,3S) AND (2S,3R) MIXTURE)

55837-20-2 (free)

Halofuginone Hydrobromide 64924-67-0

(2R*,3S*)-7-Bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-4-3H-quinazolinone hydrobromide

RU-19110(HBr)

RU-19110 (hydrobromide)

7-Bromo-6-chloro-3-(3-((2S,3R)-rel-3-hydroxypiperidin-2-yl)-2-oxopropyl)quinazolin-4(3H)-one hydrobromide

Haloperidone hydrobromide

(3R,4R)-4-(2,5-Difluoro-phenyl)-3-methyl-4-[1,2,4]triazol-1-ylmethyl-oxetan-2-one

64924-67-0

C16H18Br2ClN3O3

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