3-AMINO-1,1'-BIPHENYL-4-CARBOXYLICACID

Product Name: 3-AMINO-1,1'-BIPHENYL-4-CARBOXYLICACID
CAS No.: 4445-43-6
Chemical Name: 3-AMINO-1,1'-BIPHENYL-4-CARBOXYLICACID
Synonyms: 2-Amino-4-phenylbenzoic acid;3-Amino-[1,1'-biphenyl]-4-carboxylic acid
CBNumber: CB91253471
Molecular Formula: C13H11NO2
Formula Weight: 213.23
MOL File: 4445-43-6.mol

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3-AMINO-1,1'-BIPHENYL-4-CARBOXYLICACID Property

Melting point:: 202.6-203.8 °C(Solv: ethanol (64-17-5))
Boiling point:: 427.0±45.0 °C(Predicted)
Density: 1.257±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 4.93±0.10(Predicted)
Appearance: Light brown to brown Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: 3764AE
Product name: 3-Amino-1,1'-biphenyl-4-carboxylicacid
Packaging: 100mg
Price: $89
Updated: 2021/12/16

Matrix Scientific

Product number: 082982
Product name: 3-Amino-1,1'-biphenyl-4-carboxylic acid
Purity: 97%
Packaging: 1g
Price: $470
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0303850
Product name: 2-AMINO-4-PHENYLBENZOIC ACID
Purity: 95.00%
Packaging: 5MG
Price: $499.79
Updated: 2021/12/16

Ambeed

Product number: A124862
Product name: 3-Amino-[1,1'-biphenyl]-4-carboxylicacid
Purity: 97%
Packaging: 100mg
Price: $32
Updated: 2021/12/16

Ambeed

Product number: A124862
Product name: 3-Amino-[1,1'-biphenyl]-4-carboxylicacid
Purity: 97%
Packaging: 250mg
Price: $59
Updated: 2021/12/16

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3-AMINO-1,1'-BIPHENYL-4-CARBOXYLICACID Chemical Properties,Usage,Production

Synthesis

20776-50-5

98-80-6

4445-43-6

Pd(PPh3)4 (0.052 g, 0.045 mmol) was added to degassed DMF (10 mL) and 1 M K2CO3 aqueous solution (7 mL) under nitrogen protection using 2-amino-4-bromobenzoic acid (0.992 g, 4.46 mmol) and phenylboronic acid (0.832 g, 6.69 mmol). The reaction mixture was stirred at 80 °C for 16 hours. Upon completion of the reaction, DMF was removed under reduced pressure.The residue was dissolved in 4 N NaOH aqueous solution (40 mL) and the aqueous phase was washed twice with ethyl acetate (2 x 50 mL). The pH of the aqueous phase was adjusted to 5 by the addition of 4 N HCl. Subsequently, the aqueous phase was extracted three times with ethyl acetate (3 x 50 mL) and once with DCM-MeOH (9:1, 50 mL). All organic phases were combined, dried with MgSO4, and the solvent was evaporated under reduced pressure to give a beige solid. The solid was ground in ether, filtered and dried to give 3-amino-[1,1'-biphenyl]-4-carboxylic acid as a beige solid (0.721 g, 76% yield). mS (ESI, m/z): 214.3 [M + H+] C13H11NO2; tR = 0.78 min.

References

[1] Patent: WO2015/173329, 2015, A1. Location in patent: Page/Page column 99

3-AMINO-1,1'-BIPHENYL-4-CARBOXYLICACID Preparation Products And Raw materials

Raw materials

Preparation Products

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3-AMINO-1,1'-BIPHENYL-4-CARBOXYLICACID Suppliers

China 19 India 1 United Kingdom 1 United States 2 Global 23

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4445-43-6, 3-AMINO-1,1'-BIPHENYL-4-CARBOXYLICACIDRelated Search:

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2-Amino-4-phenylbenzoic acid

3-Amino-[1,1'-biphenyl]-4-carboxylic acid

4445-43-6

Carboxylic Acids

Fused Ring Systems