ChemicalBook > CAS DataBase List > 7-[4-[(3-phenylphenyl)methyl]piperazin-1-yl]-3H-benzooxazol-2-one

7-[4-[(3-phenylphenyl)methyl]piperazin-1-yl]-3H-benzooxazol-2-one

Product Name
7-[4-[(3-phenylphenyl)methyl]piperazin-1-yl]-3H-benzooxazol-2-one
CAS No.
350992-10-8
Chemical Name
7-[4-[(3-phenylphenyl)methyl]piperazin-1-yl]-3H-benzooxazol-2-one
Synonyms
Bifeprunox;7-[4-[(3-phenylphenyl)methyl]piperazin-1-yl]-3H-benzooxazol-2-one;7-[4-[(3-phenylphenyl)methyl]-1-piperazinyl]-3H-1,3-benzoxazol-2-one;2(3H)-Benzoxazolone, 7-[4-([1,1'-biphenyl]-3-ylmethyl)-1-piperazinyl]-;7-(4-([1,1,-biphenyl]-3-ylmethyl)piperazin-1-yl)benzo[d]oxazol-2(3H)-one
CBNumber
CB91261283
Molecular Formula
C24H23N3O2
Formula Weight
385.46
MOL File
350992-10-8.mol
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0016354
Product name
BIFEPRUNOX
Purity
95.00%
Packaging
5MG
Price
$497.78
Updated
2021/12/16
DC Chemicals
Product number
011744
Product name
Bifeprunox
Packaging
002
Price
$400
Updated
2021/12/16
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7-[4-[(3-phenylphenyl)methyl]piperazin-1-yl]-3H-benzooxazol-2-one Chemical Properties,Usage,Production

Uses

Acute schizophrenia.

Definition

ChEBI: Bifeprunox is a member of biphenyls.

in vivo

Bifeprunox (0.001-2.5 mg/kg) reduces marble burying in mice[2].
Bifeprunox (4-250 μg/kg) influences nicotine-seeking behaviour in response to drug-associated stimuli in rats[3].

Animal Model:Male NMRI mice (weighing 20-22 g)[2]
Dosage:0.001, 0.0025, 0.01, 0.04, 0.16, 0.63, and 2.5 mg/kg
Administration:I.p.
Result:Reduced marble burying. Potently active from 0.0025 mg/kg.
Animal Model:Na?ve male Wistar rats (weighing 250-275 g)[3]
Dosage:4, 16, 64 and 250 μg/kg
Administration:Injected s.c. 30 minutes before testing
Result:4-16 μg/kg dose-dependently attenuated the responsereinstating effects of nicotine-associated cues. Higher doses (64-250 μg/kg, s.c.) reduced spontaneous locomotor activity and suppressed operant responding induced by sucrose-associated cues and by the primary reinforcing properties of nicotine or sucrose.

IC 50

5-HT1A Receptor: 7.19 (pKi, cortex); D2 Receptor: 8.83 (pKi, striatum); 5-HT1A Receptor: 6.37 (pEC50, hippocampus)

7-[4-[(3-phenylphenyl)methyl]piperazin-1-yl]-3H-benzooxazol-2-one Preparation Products And Raw materials

Raw materials

Preparation Products

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7-[4-[(3-phenylphenyl)methyl]piperazin-1-yl]-3H-benzooxazol-2-one Suppliers

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350992-10-8, 7-[4-[(3-phenylphenyl)methyl]piperazin-1-yl]-3H-benzooxazol-2-oneRelated Search:

2(3H)-Benzoxazolone,7-amino-(9CI) BIFEPRUNOX MESYLATE 7-[4-[(3-phenylphenyl)methyl]piperazin-1-yl]-3H-benzooxazol-2-one

  • 7-[4-[(3-phenylphenyl)methyl]piperazin-1-yl]-3H-benzooxazol-2-one
  • Bifeprunox
  • 7-(4-([1,1,-biphenyl]-3-ylmethyl)piperazin-1-yl)benzo[d]oxazol-2(3H)-one
  • 7-[4-[(3-phenylphenyl)methyl]-1-piperazinyl]-3H-1,3-benzoxazol-2-one
  • 2(3H)-Benzoxazolone, 7-[4-([1,1'-biphenyl]-3-ylmethyl)-1-piperazinyl]-
  • 350992-10-8