2(3H)-Benzoxazolone,7-amino-(9CI)
- Product Name
- 2(3H)-Benzoxazolone,7-amino-(9CI)
- CAS No.
- 81282-60-2
- Chemical Name
- 2(3H)-Benzoxazolone,7-amino-(9CI)
- Synonyms
- Pardoprunox Impurity 1;7-Amino-2-benzoxazolone;7-Amino-2-benzoxazolinone;7-Aminobenzoxazol-2(3H)-one;7-Amino-2-benzoxazolinone>7-Amino-2-hydroxybenzoxazole;2(3H)-Benzoxazolone, 7-amino-;7-Aminobenzo[d]oxazol-2(3H)-one;7-amino-3h-1,3-benzoxazol-2-one;7-Amino-1,3-benzoxazol-2(3H)-one
- CBNumber
- CB91281906
- Molecular Formula
- C7H6N2O2
- Formula Weight
- 150.13
- MOL File
- 81282-60-2.mol
2(3H)-Benzoxazolone,7-amino-(9CI) Property
- Density
- 1.438±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- soluble in Acetone, Chloroform, Ethyl Acetate, Methanol
- form
- powder to crystal
- pka
- 9.06±0.70(Predicted)
- color
- White to Yellow to Orange
Safety
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A2806
- Product name
- 7-Amino-2-benzoxazolinone
- Purity
- >95.0%(GC)(T)
- Packaging
- 250mg
- Price
- $40
- Updated
- 2025/07/31
- Product number
- A2806
- Product name
- 7-Amino-2-benzoxazolinone
- Purity
- >95.0%(GC)(T)
- Packaging
- 1g
- Price
- $110
- Updated
- 2025/07/31
- Product number
- A593750
- Product name
- 7-Amino-2(3H)-benzoxazolone
- Packaging
- 250mg
- Price
- $1100
- Updated
- 2021/12/16
- Product number
- 2624AC
- Product name
- 7-Aminobenzo[d]oxazol-2(3H)-one
- Packaging
- 100mg
- Price
- $88
- Updated
- 2021/12/16
- Product number
- 2624AC
- Product name
- 7-Aminobenzo[d]oxazol-2(3H)-one
- Packaging
- 1g
- Price
- $138
- Updated
- 2021/12/16
2(3H)-Benzoxazolone,7-amino-(9CI) Chemical Properties,Usage,Production
Chemical Properties
Tan Solid
Uses
Intermediate for the preparation of bifeprunox mesylate
Synthesis
811810-67-0
81282-60-2
General procedure for the synthesis of 7-amino-2(3H)-benzoxazolone from 5-chloro-7-nitrobenzo[d]oxazol-2(3H)-one: Compound 6 (4 g, 18.56 mmol) was dissolved in a 4:1 MeOH/DMF solvent mixture (50 ml) and 10% Pd/C catalyst (500 mg) was added. The hydrogenation reaction was carried out at 60 psi hydrogen pressure overnight. The progress of the reaction was monitored by TLC (unfolding agent ratio ethyl acetate:petroleum ether = 3:7). After completion of the reaction, the reaction mixture was filtered through a diatomaceous earth pad and the filtrate was concentrated under vacuum. The crude product was crystallized with ether to give 2.8 g of beige solid in 99% yield. The structure of the product was confirmed by 1HNMR (DMSO-d6, 200 MHz): δ5.31 (2H, bs, NH2), 6.26 (1H, dd, J = 7.6 Hz, J'= 1 Hz, Ar-H), 6.38 (1H, dd, J = 8.4 Hz, J'= 1.2 Hz, Ar-H), 6.80 (1H, t, J = 8 Hz, Ar-H), 11.32 (1H, bs, NH).
References
[1] Patent: EP2377850, 2011, A1. Location in patent: Page/Page column 22
[2] Patent: US2006/194812, 2006, A1. Location in patent: Page/Page column 6
[3] Patent: WO2005/16898, 2005, A2. Location in patent: Page/Page column 11
[4] Patent: US2006/40932, 2006, A1. Location in patent: Page/Page column 5
[5] Patent: US2010/119622, 2010, A1. Location in patent: Page/Page column 17
2(3H)-Benzoxazolone,7-amino-(9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2(3H)-Benzoxazolone,7-amino-(9CI) manufacturers
- Product
- 7-Amino-1,3-benzoxazol-2(3H)-one 81282-60-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 20 tons
- Release date
- 2020-01-09