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Sapacitabine

Product Name
Sapacitabine
CAS No.
151823-14-2
Chemical Name
Sapacitabine
Synonyms
CNDAC;CS-682;CYC 682;CS-2513;Sapacitabine;10G, 50G, 100G, 1KG;Sapacitabine (CS682;Sapacitabine (CYC682);CYC 682; CYC-682; CS-682; CS682; CS 682;1-(2-Deoxy-2-cyano-β-D-arabinofuranosyl)cytosine
CBNumber
CB91261450
Molecular Formula
C26H42N4O5
Formula Weight
490.64
MOL File
151823-14-2.mol
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Sapacitabine Property

Melting point:
>177°C (dec.)
Density 
1.21±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer, Under inert atmosphere
solubility 
DMSO (Slightly), Methanol (Slightly, Heated)
pka
10.04±0.20(Predicted)
form 
Solid
color 
White to Off-White
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2594
Product name
Sapacitabine
Packaging
5mg
Price
$78.1
Updated
2024/03/01
Sigma-Aldrich
Product number
SML2594
Product name
Sapacitabine
Packaging
25mg
Price
$395
Updated
2024/03/01
TRC
Product number
S116505
Product name
Sapacitabine
Packaging
5mg
Price
$120
Updated
2021/12/16
Usbiological
Product number
465855
Product name
Sapacitabine
Packaging
1mg
Price
$360
Updated
2021/12/16
ChemScene
Product number
CS-0006340
Product name
Sapacitabine
Purity
98.51%
Packaging
100mg
Price
$1240
Updated
2021/12/16
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Sapacitabine Chemical Properties,Usage,Production

Uses

Sapacitabine, it is an orally available nucleoside analog prodrug of CNDAC that acts through a dual mechanism. It has potential use in chemotherapy.

Definition

ChEBI: Sapacitabine is a nucleoside analogue resulting from the formal condensation of the carboxy group of hexadecanoic acid with the amino group of CNDAC. It is the prodrug of CNDAC and is currently in clinical development for the treatment of acute myeloid leukemia (AML). It has a role as an antimetabolite, an antineoplastic agent, a prodrug and a DNA synthesis inhibitor. It is a nucleoside analogue, a nitrile and a secondary carboxamide. It is functionally related to a hexadecanoic acid and a CNDAC.

Biochem/physiol Actions

Sapacitabine is an orally active prodrug of nucleoside analog CNDAC that exhibits potent anti-tumor activity in both blood and solid tumors. CNDAC incorporates into DNA where it causes single-strand breaks (SSBs), which are converted into double strand breaks (DSBs) during S phase.

Sapacitabine Preparation Products And Raw materials

Raw materials

Preparation Products

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Sapacitabine Suppliers

China 45 United States 8 Global 53
Shanghai Boyle Chemical Co., Ltd.
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View Lastest Price from Sapacitabine manufacturers

Career Henan Chemical Co
Product
Sapacitabine 151823-14-2
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
100kg
Release date
2018-12-24

151823-14-2, SapacitabineRelated Search:

Methylene dithiocyanate Tris(hydroxymethyl)nitromethane CHLOROPHOSPHONAZO III Sodium cyanoborohydride Cyanoacetic acid ETHYL 2-CYANOACRYLATE 4-Ethyl-5-fluoro-6-hydroxypyrimidine 4,6-Dihydroxypyrimidine Sapacitabine Cyano

  • N-[1-[(2R,3S,4S,5R)-3-cyano-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2- oxo-pyrimidin-4-yl]hexadecanamide
  • Sapacitabine
  • 1-(2-C-Cyano-2-deoxy-β-D-arabino-pentofuranosyl)cytosine
  • 1-(2-Deoxy-2-cyano-β-D-arabinofuranosyl)cytosine
  • 4-Amino-1-[(3β-cyano-4α-hydroxy-5β-hydroxymethyltetrahydrofuran)-2β-yl]pyrimidin-2(1H)-one
  • CNDAC
  • 1-(2-cyano-2-deoxy-β-D-arabinofuranosyl)-4-(palMitoylaMino)pyriMidin-2(1H)-one,Sapacitabine
  • 2'-cyano-2'-deoxy-N4-palMitoyl-1-β-D-arabinofuranosyl-cytosine, sapacitabine, CYC682
  • CYC 682
  • Sapacitabine (CYC682)
  • 10G, 50G, 100G, 1KG
  • CS-682
  • CS-2513
  • CYC 682; CYC-682; CS-682; CS682; CS 682
  • Hexadecanamide, N-[1-(2-cyano-2-deoxy-β-D-arabinofuranosyl)-1,2-dihydro-2-oxo-4-pyrimidinyl]-
  • Sapacitabine (CS682
  • 151823-14-2
  • 50-27-8
  • C26H42N4O5