2,4-Difluoro-5-nitrophenol
- Product Name
- 2,4-Difluoro-5-nitrophenol
- CAS No.
- 113512-57-5
- Chemical Name
- 2,4-Difluoro-5-nitrophenol
- Synonyms
- ,4-Difluoro-5-nitrophenol;2,4-Difluoro-5-nitrophenol;Phenol, 2,4-difluoro-5-nitro-;2,4-Difluoro-5-nitrophenol,98%;2,4-Difluoro-5-hydroxynitrobenzene
- CBNumber
- CB91261672
- Molecular Formula
- C6H3F2NO3
- Formula Weight
- 175.09
- MOL File
- 113512-57-5.mol
2,4-Difluoro-5-nitrophenol Property
- Melting point:
- 112-120℃
- Boiling point:
- 160-162 °C(Press: 24 Torr)
- Density
- 1.619±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 6.81±0.24(Predicted)
- Appearance
- Light yellow to green yellow Solid
- Water Solubility
- Sparingly soluble in water but readily soluble in organic solvents.
Safety
- HS Code
- 2908990000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- D452210
- Product name
- 2,4-Difluoro-5-nitrophenol
- Packaging
- 250mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- PC8736
- Product name
- 2,4-Difluoro-5-nitrophenol
- Packaging
- 1g
- Price
- $35
- Updated
- 2021/12/16
- Product number
- 4654-3-60
- Product name
- 2,4-Difluoro-5-nitrophenol
- Packaging
- 1g
- Price
- $39
- Updated
- 2021/12/16
- Product number
- FD104935
- Product name
- 2,4-Difluoro-5-nitrophenol
- Packaging
- 1g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- PC8736
- Product name
- 2,4-Difluoro-5-nitrophenol
- Packaging
- 5g
- Price
- $87
- Updated
- 2021/12/16
2,4-Difluoro-5-nitrophenol Chemical Properties,Usage,Production
Uses
2,4-Difluoro-5-nitrophenol may be used in chemical synthesis.
Synthesis
152169-43-2
113512-57-5
Using 2,4-difluorophenyl ethyl carbonate (3.1 g, 16 mmol) as raw material, nitric acid (0.78 ml, 19 mmol) was slowly added to a solution of sulfuric acid (10 mL) at 0 °C, keeping the reaction temperature at about 0 °C. After 15 min of reaction, the reaction was terminated by adding ice-cold water (70 mL), and the product was extracted with ethyl acetate (2 × 50 mL). The organic layers were combined, washed with brine, dried over anhydrous sodium sulfate, and concentrated to give the nitro product as a thick syrup. The nitro product was dissolved in methanol (20 mL), solid sodium bicarbonate (4.0 g, 47 mmol) was added and stirred for 16 hours at room temperature. After completion of the reaction, the mixture was filtered and the filtrate was concentrated. The resulting solid was dissolved in water (20 ml) and acidified with 3M HCl solution to pH~5. The product was extracted with dichloromethane (3 x 25 mL), the organic layers were combined, washed with brine, dried over anhydrous sodium sulfate, and concentrated to give 2,4-difluoro-5-nitrophenol (2.34 g, 84% yield). The product was confirmed by 1H NMR (400 MHz, acetone-d6): δ 9.59 (s, 1H), 7.78 (t, J=7.2 Hz, 1H), 7.45 (t, J=10.4 Hz, 1H); mass spectrometry (ESI) m/z: 176.0 (M+H+).
References
[1] Patent: WO2013/36232, 2013, A2. Location in patent: Paragraph 00224
[2] Synthesis, 1997, # 12, p. 1446 - 1450
[3] Patent: EP755928, 1997, A1
2,4-Difluoro-5-nitrophenol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,4-Difluoro-5-nitrophenol manufacturers
- Product
- 2,4-Difluoro-5-nitrophenol 113512-57-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-09